Mapping of Aldose Reductase Gene Sequences to Human Chromosomes 1, 3, 7, 9, 11, and 13
Genomics, 1993 Aldose reductase (alditol:NAD(P)+ 1-oxidoreductase; EC 1.1.1.21) (AR) catalyzes the reduction of several aldehydes, including that of glucose, to the corresponding sugar alcohol. Using a complementary DNA clone encoding human AR, we mapped the gene sequences to human chromosomes 1, 3, 7, 9, 11, 13, 14, and 18 by somatic cell hybridization.
J B, Bateman +8 more
openaire +3 more sources
Biological effects of conventional and ultra high dose rate radiation in human cells [PDF]
Scientific ReportsFLASH radiotherapy (FLASH-RT) that uses an ultra-high dose rate (UHDR) radiation is emerging as an effective cancer treatment modality but the biological effects of UHDR are not fully understood.
Terri L. Ryan +13 more
doaj +2 more sources
Life, 2023 The Cercopithecini tribe includes terrestrial and arboreal clades whose relationships are controversial, with a high level of chromosome rearrangements.
Vanessa Milioto +2 more
doaj +1 more source
Animals, 2023 There are extensive studies on chromosome morphology and karyotype diversity in primates, yet we still lack insight into genomic instability as a key factor underlying the enormous interspecies chromosomal variability and its potential contribution to ...
Mariela Nieves +4 more
doaj +1 more source
Spatial positioning of all 24 chromosomes in the lymphocytes of six subjects: evidence of reproducible positioning and spatial repositioning following DNA damage with hydrogen peroxide and ultraviolet B. [PDF]
PLoS ONE, 2015 The higher-order organization of chromatin is well-established, with chromosomes occupying distinct positions within the interphase nucleus. Chromatin is susceptible to, and constantly assaulted by both endogenous and exogenous threats.
Dimitrios Ioannou +5 more
doaj +1 more source
, 2023 Supplementary Materials and Tables 1-3 from Chromosomal Instability Correlates with Genome-wide DNA Demethylation in Human Primary Colorectal ...
Miguel A. Peinado +10 more
openaire +1 more source
No evidence for a second evolutionary stratum during the early evolution of mammalian sex chromosomes. [PDF]
PLoS ONE, 2012 Mammalian sex chromosomes originated from a pair of autosomes, and homologous genes on the sex chromosomes (gametologs) differentiated through recombination arrest between the chromosomes.
Yukako Katsura, Yoko Satta
doaj +1 more source
Unified theory of human genome reveals a constrained spatial chromosomal arrangement in interphase nuclei [PDF]
, 2015 We investigate a densely packed, non-random arrangement of forty-six chromosomes (46,XY) in human nuclei. Here, we model systems-level chromosomal crosstalk by unifying intrinsic parameters (chromosomal length and number of genes) across all pairs of ...
Fatakia, Sarosh N. +2 more
core +2 more sources
Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding. [PDF]
PLoS ONE, 2015 Ends of human chromosomes consist of the six nucleotide repeat d[pTTAGGG]n known as telomeric DNA, which protects chromosomes. We have previously shown that the DHX36 gene product, G4 Resolvase 1 (G4R1), binds parallel G-quadruplex (G4) DNA with an ...
Philip J Smaldino +7 more
doaj +1 more source
Genetic Influence on Frequencies of Myeloid-Derived Cell Subpopulations in Mouse
Frontiers in Immunology, 2022 Differences in frequencies of blood cell subpopulations were reported to influence the course of infections, atopic and autoimmune diseases, and cancer.
Imtissal Krayem +12 more
doaj +1 more source