Results 41 to 50 of about 421,555 (247)

New chemically induced skin tumour susceptibility loci identified in a mouse backcross between FVB and dominant resistant PWK

BMC Genetics, 2007
Background A variety of skin cancer susceptibility among mouse strains has allowed identification of genes responsible for skin cancer development. Fifteen Skts loci for skin tumour susceptibility have been mapped so far by using the two-stage skin ...
Irahara Natsumi, Igarashi Jun, Fujiwara Kyoko, Kimura Makoto, Nagase Hiroki   +4 more
doaj   +1 more source

The self-organization of genomes [PDF]

, 2010
Menzerath-Altmann law is a general law of human language stating, for instance, that the longer a word, the shorter its syllables. With the metaphor that genomes are words and chromosomes are syllables, we examine if genomes also obey the law.
Ferrer Cancho, Ramon, Forns Fradera, Núria   +1 more
core   +2 more sources

Homologies in human and Macasa fuscata chromosomes revealed by in situ suppression hybridization with human chromosome specific DNA libraries [PDF]

, 1992
We established chromosomal homologies between all chromosomes of the human karyotype and that of an old world monkey (Macaca fuscata) by chromosomal in situ suppression (CISS) hybridization with human chromosome specific DNA libraries.
Cremer, Thomas, Jauch, Anna, Stanyon, Roscoe, Wienberg, Johannes   +3 more
core   +1 more source

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

Evolutionary dynamics of adult stem cells: Comparison of random and immortal strand segregation mechanisms

, 2004
This paper develops a point-mutation model describing the evolutionary dynamics of a population of adult stem cells. Such a model may prove useful for quantitative studies of tissue aging and the emergence of cancer.
A. T. Natarajan, C. S. Potten, D. Voet, J. R. Merok, T. Helleday   +4 more
core   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Identification of QTLs for low somatic cell count in Murrah buffaloes

Indian Journal of Animal Sciences, 2019
Mastitis, the most frequent and costly disease in buffalo, is the major cause of morbidity. The somatic cell count, an indirect indicator of susceptibility/resistance to mastitis, is a low heritable trait and thus a perfect candidate for marker assisted ...
UPASNA SHARMA, PRIYANKA BANERJEE, JYOTI JOSHI, PRERNA KAPOOR, RAMESH KUMAR VIJH   +4 more
doaj   +1 more source

Chromosome assignment of two cloned DNA probes hybridizing predominantly to human sex chromosomes [PDF]

, 1984
In situ hybridization experiments were carried out with two clones, YACG 35 and 2.8, which had been selected from two genomic libraries strongly enriched for the human Y chromosome.
A Chapelle de la, AJ Solari, AJ Solari, BD Young, BR Migeon, C Cremer, CR M�ller, CR M�ller, D Page, DT Denhardt, EMJ Southern, GM Wahl, J Fantes, JBS Haldane, JW Gray, KE Davies, L Zech, LM Kunkel, LM Kunkel, MJ Moses, P Goodfellow, P Leder, P Polani, PK Horan, PL Pearson, PN Dean, PN Dean, PN Goodfellow, PS Burgoyne, PS Gerhard, R Krumlauf, RG Langlois, SP Daiger, T Mohandas, U M�ller   +34 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Rapid metaphase and interphase detection of radiation-induced chromosome aberrations in human lymphocytes by chromosomal suppression in situ hybridization [PDF]

, 1990
Chromosomal in situ suppression (CISS)-hybridization of biotinylated phage DNA-library inserts from sorted human chromosomes was used to decorate chromosomes 1 and 7 specifically from pter to qter and to detect structural aberrations of these chromosomes
Cremer, Christoph, Cremer, Thomas, Emmerich, Patricia, Lichter, Peter, Popp, Susanne   +4 more
core   +1 more source