Results 41 to 50 of about 248,131 (206)

Identification of novel schizophrenia loci by homozygosity mapping using DNA microarray analysis. [PDF]

PLoS ONE, 2011
The recent development of high-resolution DNA microarrays, in which hundreds of thousands of single nucleotide polymorphisms (SNPs) are genotyped, enables the rapid identification of susceptibility genes for complex diseases.
Naohiro Kurotaki, Shinya Tasaki, Hiroyuki Mishima, Shinji Ono, Akira Imamura, Taeko Kikuchi, Nao Nishida, Katsushi Tokunaga, Koh-ichiro Yoshiura, Hiroki Ozawa   +9 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Cytogenetic analysis on Herichthys minckleyi (Perciformes, Cichlidae) from Cuatrociénegas, Coahuila, México

The European Zoological Journal
The purpose of this work was to use standard Giemsa staining and several chromosome-banding procedures to define the karyotype of Herichthys minckleyi (Perciformes, Cichlidae) from Cuatrociénegas, Coahuila, Mexico.
R. E. Mendoza-Alfaro, E. I. Cortés-Gutiérrez, M. I. Dávila-Rodríguez, C. García-Vielma, D. Montiel-Condado   +4 more
doaj   +1 more source

Identifying Candidate Genes for Enhancing Grain Zn Concentration in Wheat

Frontiers in Plant Science, 2018
Wheat (Triticum aestivum L.) is one of the major staple food crops worldwide. Despite efforts in improving wheat quality, micronutrient levels are still below the optimal range for human nutrition.
Dalia Z. Alomari, Kai Eggert, Nicolaus von Wirén, Ahmad M. Alqudah, Andreas Polley, Jörg Plieske, Martin W. Ganal, Klaus Pillen, Marion S. Röder   +8 more
doaj   +1 more source

Dissecting the genetic basis of drought responses in common bean using natural variation

Frontiers in Plant Science, 2023
The common bean (Phaseolus vulgaris L) is the most important legume for human consumption, contributing 30% of the total daily protein intake in developing countries.
Diana Labastida, Diana Labastida, Pär K. Ingvarsson, Martha Rendón-Anaya   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Inflammatory Bowel Disease: Progress Towards a Gene

Canadian Journal of Gastroenterology, 2000
The pathogenesis of ulcerative colitis (UC) and Crohn’s disease (CD) is still unknown, but the importance of genetic susceptibility has been clearly shown by epidemiological data from family and twin studies.
David A van Heel, Jack Satsangi, Alisoun H Carey, Derek P Jewell   +3 more
doaj   +1 more source

Analysis of human sarcospan as a candidate gene for CFEOM1

BMC Genetics, 2001
Background Congenital fibrosis of the extraocular muscles type 1 (CFEOM1) is an autosomal dominant eye movement disorder linked to the pericentromere of chromosome 12 (12p11.2 - q12).
Engle Elizabeth C, O'Brien Kristine F, Kunkel Louis M   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source