Results 161 to 170 of about 167,976 (219)

Endometrial Epithelial Lactate Deficiency Drives CD8+ T‐Cells Dysregulation in Unexplained Recurrent Implantation Failure

Advanced Science, EarlyView.
Unexplained recurrent implantation failure (RIF) represents a significant clinical challenge. Our results demonstrate that reduced lactate production in the RIF endometrium impairs the suppression of cytotoxic CD8+ T‑cells, allowing their proliferation and thereby disrupting the local immune balance essential for successful embryo implantation.
Yuanlin He, Kang Ke, Qingxia Meng, Yichun Guan, Jichun Tan, Hong Lv, Boxian Huang, Chan Tian, Qinyan Zou, Mingxing An, Yao Gao, Jingjing Chen, Xiaoyu Wei, Xi Wang, Hongxia Ma, Yuan Lin, Feiyang Diao, Yayun Gu, Zhibin Hu   +18 more
wiley   +1 more source

CENP-E initiates chromosome congression by opposing Aurora kinases to promote end-on attachments. [PDF]

Nat Commun
Vukušić K, Tolić IM.
europepmc   +1 more source

A CLE11b‐CLE16 Signaling Relay Mediates Root‐Shoot‐Root Crosstalk for Drought Adaptation in Common Bean

Advanced Science, EarlyView.
A novel root‐shoot‐root signaling relay, mediated by CLE peptides, coordinates drought adaptation in common bean. Root‐derived PvCLE11b translocates acropetally to leaves, inducing PvCLE16 expression via PvTCP10. Leaf‐accumulated PvCLE16 triggers stomatal closure and translocates basipetally to modulate root architecture.
Xinyang Wu, Shiyuan Tao, Zhuoyi Wang, Ting Sun, Zixin Zhang, Su Yang, Min Xu, Chenyi Huang, Siyi Wang, Xubo Ke, Chenze Lu, Kang Ning, Pei Xu   +12 more
wiley   +1 more source

Comparative genomics of Borrelia lusitaniae. [PDF]

G3 (Bethesda)
Lopes de Carvalho I, Núncio MS, Norte AC, Mongodin EF, Luft BJ, Schutzer SE, Yang X, Fraser CM, Hepner S, Fingerle V, Margos G, Morgan R, Akther S, Qiu W, Casjens SR.   +14 more
europepmc   +1 more source

Cell Cycle‐Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET

Advanced Science, EarlyView.
CDK5RAP2 associates with the kinesin HSET and forms co‐condensates. HSET motors drive the directional transport of CDK5RAP2 condensates toward microtubule minus ends. During mitosis, HSET self‐assembly further stabilizes clustered centrosomes, thereby enabling pseudo‐bipolar spindle formation in cancer cells with supernumerary centrosomes. Upon mitotic
Po‐Pang Chen, Athira Saju, Chia‐Chou Wu, Tzu‐Han Weng, Su‐Yi Tsai, Tzu‐Lun Huang, Jia‐Ying Su, Chien‐Ling Lin, Yu‐Chun Lin, See‐Yeun Ting, Sheng‐hong Chen, Kuo‐Chiang Hsia   +11 more
wiley   +1 more source

A chromosome-level genome assembly of Coryphaenoides armatus. [PDF]

Sci Data
Wu B, Yu H, Luo T, Lu B, Lin Q, Zhang Y.
europepmc   +1 more source

Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy

Advanced Science, EarlyView.
Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin   +12 more
wiley   +1 more source

Genomic introgressions from wild relatives in the wheat genome alter meiotic dynamics in inter-varietal hybrids. [PDF]

Plant J
Yan L, Chéron F, Nadaud I, Hao M, Liu D, Sourdille P.   +5 more
europepmc   +1 more source

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

Single Cell RNA Transcriptomics of Mantle Cell Lymphoma Reveals the Presence of Treatment‐Resistant Subclones at the Time of Diagnosis

American Journal of Hematology, EarlyView.
ABSTRACT Mantle cell lymphoma (MCL) is a B‐cell malignancy with a chronically relapsing clinical course and pronounced genetic heterogeneity. To investigate the clonal dynamics underlying early disease relapse, we performed single‐cell RNA sequencing of paired tumor samples collected at diagnosis and at first relapse. Inference of copy number variants (
Dmitry Manakov, Magdalena Klanova, Michal Kolar, Robert Ivanek, Florian Geier, Julien Roux, Tomas Zikmund, Lucie Winkowska, Eva Kriegova, Jirina Manakova, Liliana Tuskova, Silvia Spanikova, Alexandra Scasna, Marek Trneny, Pavel Klener   +14 more
wiley   +1 more source