Results 1 to 10 of about 259,540 (309)
Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes. [PDF]
PLoS Genetics, 2010 Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division.
Kaitlin M Stimpson +6 more
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Фундаментальная и клиническая медицина, 2021 Cytogenetics is an essential part of human genetics which studies the structure of chromosomes and their collection which is called karyotype. Cytogenetic techniques are employed while interrogating DNA organisation and compaction.
A. N. Volkov, L. V. Nacheva
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Modeling protein target search in human chromosomes
Physical Review Research, 2021 Several processes in the cell, such as gene regulation, start when key proteins recognize and bind to short DNA sequences. However, as these sequences can be hundreds of million times shorter than the genome, they are hard to find by simple diffusion ...
Markus Nyberg +3 more
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Panel of human cell lines with human/mouse artificial chromosomes
Scientific Reports, 2022 Human artificial chromosomes (HACs) and mouse artificial chromosomes (MACs) are non-integrating chromosomal gene delivery vectors for molecular biology research.
Narumi Uno +16 more
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Developmental Delay and Rehabilitation in an Infant with Partial Trisomy 1q32.1 to 1q44: A Case Report [PDF]
Neonatal Medicine, 2022 Partial trisomy 1q is a rare chromosomal disorder characterized by ventriculomegaly with craniofacial, renal, cardiac, and finger and toe anomalies. Most reported cases of partial trisomy1q have involved stillborn or premature deaths due to cardiac or ...
Woo Kyung Kim +6 more
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Molecular Cytogenetics, 2018 Background Children with constitutional trisomy 21, i.e. Down syndrome (DS, OMIM #190685) have a 10 to 20-fold increased risk for a hematopoietic malignancy. They may suffer from acute lymphoblastic leukemia or acute myeloid leukemia (AML).
Faten Moassass +4 more
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Non-random Mis-segregation of Human Chromosomes
Cell Reports, 2018 Summary: A common assumption is that human chromosomes carry equal chances of mis-segregation during compromised cell division. Human chromosomes vary in multiple parameters that might generate bias, but technological limitations have precluded a ...
Joseph Thomas Worrall +9 more
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Homologies in human and Macasa fuscata chromosomes revealed by in situ suppression hybridization with human chromosome specific DNA libraries [PDF]
, 1992 We established chromosomal homologies between all chromosomes of the human karyotype and that of an old world monkey (Macaca fuscata) by chromosomal in situ suppression (CISS) hybridization with human chromosome specific DNA libraries.
Stanyon, Roscoe +3 more
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Molecular Cytogenetics, 2009 Background The objective of this work is to obtain the correct relative DNA contents of chromosomes in the normal male and female human diploid genomes for the use at FISH analysis of radiation-induced chromosome aberrations.
Repin Mikhail V +2 more
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Natural selection reduced diversity on human y chromosomes. [PDF]
PLoS Genetics, 2014 The human Y chromosome exhibits surprisingly low levels of genetic diversity. This could result from neutral processes if the effective population size of males is reduced relative to females due to a higher variance in the number of offspring from males
Melissa A Wilson Sayres +2 more
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