Results 71 to 80 of about 7,790,467 (300)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

IMACULAT - an open access package for the quantitative analysis of chromosome localization in the nucleus. [PDF]

PLoS ONE, 2013
The alteration in the location of the chromosomes within the nucleus upon action of internal or external stimuli has been implicated in altering genome function.
Ishita Mehta, Sandeep Chakraborty, Basuthkar J Rao   +2 more
doaj   +1 more source

Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund.Background: Radial chromosome positioning in interphase nuclei is nonrandom and can alter according to developmental, differentiation, proliferation, or disease status.
Ishita S Mehta, Bridger, JM, Joanna M Bridger, Mehta, IS, Manelle Amira, Harvey, AJ, Amira, M, Amanda J Harvey   +7 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Human Ring Chromosomes – New Insights for their Clinical Significance

Balkan Journal of Medical Genetics, 2013
Twenty-nine as yet unreported ring chromosomes were characterized in detail by cytogenetic and molecular techniques. For FISH (fluorescence in situ hybridization) previously published high resolution approaches such as multicolor banding (MCB ...
Guilherme R.S., Klein E, Hamid A.B., Bhatt S, Volleth M, Polityko A, Kulpanovich A, Dufke A, Albrecht B, Morlot S, Brecevic L, Petersen M.B., Manolakos E, Kosyakova N, Liehr T   +14 more
doaj   +1 more source

DDX11L: a novel transcript family emerging from human subtelomeric regions

BMC Genomics, 2009
Background The subtelomeric regions of human chromosomes exhibit an extraordinary plasticity. To date, due to the high GC content and to the presence of telomeric repeats, the subtelomeric sequences are underrepresented in the genomic libraries and ...
D'Urso Michele, Matarazzo Maria R, Gianfrancesco Fernando, Roberto Roberta, Casamassimi Amelia, Costa Valerio, D'Esposito Maurizio, Rocchi Mariano, Ciccodicola Alfredo   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impaired CENP-E Function Renders Large Chromosomes More Vulnerable to Congression Failure

Biomolecules, 2019
It has recently emerged that human chromosomes vary between one another in terms of features that impact their behaviour during impaired chromosome segregation, leading to non-random aneuploidy in the daughter cell population.
Laura Tovini, Sarah E. McClelland
doaj   +1 more source

Modeling meiotic chromosomes indicates a size dependent contribution of telomere clustering and chromosome rigidity to homologue juxtaposition [PDF]

, 2012
Meiosis is the cell division that halves the genetic component of diploid cells to form gametes or spores. To achieve this, meiotic cells undergo a radical spatial reorganisation of chromosomes.
Penfold, Christopher A., Paul E Brown, Paul E. Brown (168021), Alastair S H Goldman, Christopher A. Penfold (168015), Neil D. Lawrence (168025), Penfold, C.A., Christopher A Penfold, Lawrence, Neil (Neil D.), Lawrence, N.D., Lawrence Neil D., Goldman Alastair S. H., Goldman, Alastair S. H., Alastair S. H. Goldman (168028), Brown Paul E., Neil D Lawrence, Penfold Christopher A., Brown, Paul E., Brown, P.E., Goldman, A.S.H.   +19 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source