Results 81 to 90 of about 164,419 (307)
Introgression in interspecific hybrids of lily [PDF]
, 2002 In order to introduce new desirable characters into the cultivar assortment of lily a range of interspecific crossing barriers has to be overcome. By using various pollination and embryo rescue techniques pre- and postfertilization barriers were overcome
Lim, K.B. +2 more
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Deciphering the genome structure and paleohistory of _Theobroma cacao_ [PDF]
, 2010 We sequenced and assembled the genome of _Theobroma cacao_, an economically important tropical fruit tree crop that is the source of chocolate. The assembly corresponds to 76% of the estimated genome size and contains almost all previously described ...
Angé +60 more
core +2 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Condensation patterns of prophase/prometaphase chromosome are correlated with H4K5 histone acetylation and genomic DNA contents in plants. [PDF]
PLoS ONE, 2017 Mitotic prophase chromosome condensation plays an essential role in nuclear division being therefore regulated by highly conserved mechanisms. However, degrees of chromatin condensation in prophase-prometaphase cells may vary along the chromosomes ...
Lidiane Feitoza +2 more
doaj +1 more source
Plant Evolution: Modern Sex Chromosomes [PDF]
Current Biology, 2004 The first detailed map has been produced of a plant chromosome carrying sex-determining genes. The new data show that, in papaya, these genes lie in a quite extensive non-recombining region. This region is nevertheless a small part of the papaya genome compared with other male-specific genome regions, such as mammalian Y chromosomes.
openaire +2 more sources
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Cytological features of penaut genome [PDF]
, 2017 The genus Arachis is composed of 82 species (Krapovickas and Gregory 1994; Valls and Simpson 2005; Valls et al 2013; Santana and Valls 2015) mainly distributed within a large region of South America, which extends from the eastern foothills of the Andes ...
Chalup, Laura María Isabel +6 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Reassessment of the evolution of wheat chromosomes 4A, 5A, and 7B. [PDF]
, 2018 Key messageComparison of genome sequences of wild emmer wheat and Aegilops tauschii suggests a novel scenario of the evolution of rearranged wheat chromosomes 4A, 5A, and 7B.
Deal, Karin R +11 more
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