Results 221 to 230 of about 1,562,582 (397)

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

The importance of having two X chromosomes

Philosophical Transactions of the Royal Society B: Biological Sciences, 2016
A. Arnold, K. Reue, M. Eghbali, E. Vilain, Xuqi Chen, Negar M. Ghahramani, Y. Itoh, Jingyuan Li, Jenny C. Link, Tuck C. Ngun, Shayna M. Williams-Burris   +10 more
semanticscholar   +1 more source

The maize B chromosome shapes the transcriptome throughout the entire plant life cycle. [PDF]

J Exp Bot
Hloušková L, Tulpová Z, Svačina R, Holušová K, Cápal P, Navrátilová P, Karafiátová M, Bartoš J.   +7 more
europepmc   +1 more source

Transcriptomic behavior of genes associated with chromosome 21 aneuploidies in early embryo development [PDF]

, 2019
Imma Sanchez-Ribas, Patricia Díaz-Gimeno, Patricia Sebastián-León, Amparo Mercader, Alicia Quiñonero, A. Ballesteros, António Pellicer, Francisco Domı́nguez   +7 more
openalex   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Chromosomes and sexual development of rodent malaria parasites

Memorias do Instituto Oswaldo Cruz, 1994
C. J. Janse, M. Ponzi, R. E. Sinden, A. P. Waters   +3 more
doaj   +1 more source

Automatic detection of sister chromatid exchanges using machine learning models and image analysis algorithms. [PDF]

Sci Rep
Teraoka M, Matsumoto S, Kawasumi R, Nishikawa K, Okubo K, Abe T.   +5 more
europepmc   +1 more source

53BP1 Protects against CtIP-Dependent Capture of Ectopic Chromosomal Sequences at the Junction of Distant Double-Strand Breaks

, 2016
Josée Guirouilh‐Barbat, Camille Gelot, Anyong Xie, Elodie Dardillac, Ralph Scully, Bernard S. López   +5 more
openalex   +2 more sources

Centromere 17 copy number gain reflects chromosomal instability in breast cancer [PDF]

, 2019
Kyoungyul Lee, Hyun Jeong Kim, Min Hye Jang, Sejoon Lee, Soomin Ahn, So Yeon Park   +5 more
openalex   +1 more source

Genome‐Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes

Advanced Science, EarlyView.
This study explores genome‐wide by lifetime environment interactions on brain imaging phenotypes. Gene‐environment interactions explain more phenotypic variance than main effects, pinpoint regulatory variants, and reveal exposure‐specific biological pathways.
Sijia Wang, Meiyun Wang, Peng Zhang, Jingliang Cheng, Longjiang Zhang, Wenzhen Zhu, Shijun Qiu, Zuojun Geng, Guangbin Cui, Yongqiang Yu, Weihua Liao, Xi‐Nian Zuo, Hui Zhang, Bo Gao, Xiaojun Xu, Tong Han, Zhenwei Yao, Quan Zhang, Feng Liu, Qiang Xu, Jiayuan Xu, Jilian Fu, Nana Liu, Yuan Ji, Jie Tang, Lining Guo, Mengge Liu, Xiaoxiao Xiao, Xiaoxuan Liu, Wei Li, Caihong Wang, Wei Wei, Dapeng Shi, Su Lui, Zhihan Yan, Feng Chen, Jing Zhang, Wen Shen, Yanwei Miao, Dawei Wang, Jia‐Hong Gao, Yunjun Yang, Kai Xu, Junfang Xian, Bing Zhang, Xiaochu Zhang, Zhaoxiang Ye, Le Yu, Wen Qin, Meng Liang, Chunshui Yu, the CHIMGEN Consortium   +51 more
wiley   +1 more source