Results 71 to 80 of about 1,793,188 (155)

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

open access: yesMedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta   +2 more
wiley   +1 more source

Squills vs. Hyacinths – A revised genus delimitation in Hyacinthinae (Hyacintheae, Scilloideae, Asparagaceae) based on phylogenomics

open access: yesTAXON, Volume 75, Issue 5, October 2026.
Abstract Scilla s.l. (Asparagaceae: Scilloideae) represents a notable Mediterranean geophyte radiation, yet genus delimitation in subtribe Hyacinthinae has long suffered from inconsistent and conflicting generic concepts. A limited set of informative morphological characters and recurrent shifts in circumscription have repeatedly hindered progress ...
Tim Böhnert   +6 more
wiley   +1 more source

Usefulness of manometry to select patients with anal fissure for controlled anal dilatation

open access: yes, 2010
Aim:To evaluate the use of anorectal manometry to select patients for controlled anal dilatation. Methodology: A prospective study was performed using anorectal manometry on all patients with chronic anal fissure who did not have a good response to ...
Maté,J.   +4 more
core   +1 more source

Sustainable Iron Catalysis for Chemodivergent Oxidation of Lignin‐Based Vanillyl Alcohol: Selective Access to Vanillin and Vanillic Acid

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 35, 19 September 2026.
Green reaction media enable chemodivergent oxidation of vanillyl alcohol, selectively affording vanillin or its fully oxidized counterpart, vanillic acid. The use of an earth‐abundant, inexpensive, and nontoxic iron catalyst for the transformation of lignin‐derived alcohol to fine chemicals underscores the sustainability of the process. A low E‐factor (
Rasmiranjan Hota   +2 more
wiley   +1 more source

Botulinum toxin A for treatment of chronic anal fissure

open access: yes, 2007
Since its introduction for the treatment of strabismus, botulinum toxin (BoNT) has been increasingly used in the treatment of several disorders with excessive or inappropriate muscle contractions.
Brisinda, Giuseppe   +8 more
core   +1 more source

INTER SPHINCTERIC BOTULINUM TOXIN A INJECTION FOR THE MANAGEMENT OF CHRONIC ANAL FISSURE

open access: yesThe Iraqi Journal of Medical Sciences, 2017
Background: Surgical sphincterotomy (SS) has been the most commonly used treatment for chronic anal fissure (CAF). Although effective, it is associated with gas and or fecal incontinence in (0-20%) inter-sphincteric Botulinum Toxin A (BTXA) injection is ...
Nashwan Q. Mahgoob, Muhammed M. kamal
doaj   +6 more sources

A Clinical Study of Fissure in Ano at Tertiary Center in North Telangana [PDF]

open access: yesPerspectives In Medical Research, 2018
Introduction: An anal fissure is a distressing problem faced by a patient. It is one of the commonest painful anal condition. It is relatively simple to treat with rewarding results.
Y Narendra1 , K Naveen Kumar2 , Samir Ahmad3
doaj  

A Combined Topical Treatment versus Surgical Treatment in Chronic Anal Fissure

open access: yes, 2021
In the treatment of chronic anal fissure, both surgical and topical treatment methods are used. The purpose of this study was to research a combined topical treatment that we prepared and to compare the effectiveness of lateral internal sphincterotomy in
Atli, Mustafa   +2 more
core   +1 more source

Medical treatment of chronic anal fissure. Where do we stand on reversible chemical sphincterotomy?

open access: yes, 2004
peer reviewedAnal fissure is a common problem which can evolve to chronicity. Chronic anal fissure is thought to be an ischemic ulceration related to sphincter hypertonia.
Van Kemseke, Catherine   +1 more
core  

Chronic anal fissure: new approaches to chemical sphincterotomy

open access: yesJournal of Research in Medical Sciences, 2008
<ul> <li>An anal fissure is a split in the mucosa extending from the anal verge towards the dentate line. It currently affects 10% of patients attending proctology clinics.
Mohammad hassan Emami   +1 more
doaj  

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