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Pharmacotherapy of anxiety disorders in patients with chronic cerebral ischemia

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2016
To compare the effects of the daytime anxiolytic adaptol and the tranquilizer/nootropic drug noophen on target symptoms related to anxiety spectrum disorders in patients with chronic cerebral ischemia (CCI).Sixty-two patients with CCI and comorbid anxiety spectrum disorders were randomized to adaptol group (n=29) and noophen group (n=33).
O V, Vorob'eva, V V, Rusaya
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Cerebral markers of endothelial dysfunction in chronic brain ischemia

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2017
A review of the main markers of endothelial dysfunction in chronic cerebral ischemia is presented. The quantitative changes in the level of endothelial dysfunction markers in chronic cerebral ischemia help to evaluate the efficacy of preventive and therapeutic pharmacological activities.
V V, Fateeva, O V, Vorob'eva
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Mechanisms of development of chronic cerebral ischemia in arterial hypertension

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2017
To study a relationship of arterial hypertension (AH) severity with the cerebral blood flow and structural changes in the brain matter, processes of lipid peroxidation and antioxidant defense, parameters of homeostasis, indicators of endothelial dysfunction and apoptosis.A complex study of 84 patients with AH, aged from 43 to 64 years, was carried out ...
O N, Voskresenskaya   +2 more
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Modern pathogenetic aspects of development of cerebral chronic ischemia

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2015
Key mechanisms of the development of cerebral blood circulation insufficiency are presented. The following initial patters are analyzed: primary cytokine response, endothelial dysfunction and functioning of neurovascular units. Current conceptions on the development of pathological apoptosis and neuroplasticity are considered.
E I, Gusev, A S, Chukanova
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Selective neuronal damage and chronic hemodynamic cerebral ischemia

Annals of Neurology, 2007
AbstractObjectiveIn atherothrombotic internal carotid artery or middle cerebral artery (MCA) occlusive disease, chronic hemodynamic compromise may increase the risk for cerebral ischemic damage. To determine whether selective neuronal damage demonstrated as a decrease in central benzodiazepine receptor (BZR) in the normal‐appearing cerebral cortex is ...
Hiroshi, Yamauchi   +4 more
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Correction of oxidative stress in patients with chronic cerebral ischemia

Clinical Medicine (Russian Journal), 2016
A pilot study ofthe effect ofthe antioxidant drug ethylmethylhydroxypyridine malate on indicators of oxidative stress in patients with chronic cerebral ischemia. At 6 day course administration investigated the antioxidant in these patients significantly accelerates the process of generation of superoxide anion radical, established by lucigenin-depended
O A, Goroshko   +7 more
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The neuroprotective therapy of outpatient treatment of chronic cerebral ischemia

Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova, 2015
To perform a differential analysis of the efficacy of combination therapy by the drugs with different modalities (mexidol, aescusan, halidorum) in outpatients with chronic cerebral ischemia (CCI), stages I- III.A study included 50 patients with CCI of atherosclerotic, hypertensive and mixed genesis (stage I - 20 patients, stage II - 20, stage III - 10 ...
S V, Berezhnaya, E Z, Yakupov
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Modern aspects of chronic cerebral ischemia pathogenetic therapy

S.S. Korsakov Journal of Neurology and Psychiatry
Chronic cerebral ischemia (CCI) is one of the most common forms of cerebrovascular disease, which affects a significant number of patients, often leading to disability, cognitive impairment and dementia. The analysis of modern data on the pathogenesis and risk factors for the development of CCI, as well as on the mechanisms of action of Mexidol on ...
S.T. Turuspekova   +7 more
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Headache and cognitive impairment in patients with chronic cerebral ischemia

S.S. Korsakov Journal of Neurology and Psychiatry
Objective. Analysis of the relationship between cognitive impairment (CI) and headache (HA) in patients with chronic cerebral ischemia (CCI). Material and methods. The study included 97 patients aged 50 to 85 years (65 females, 32 males) diagnosed with CCI.
V.A. Vershuta   +2 more
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Complex Energy Correction in Chronic Cerebral Ischemia

Neuroscience and Behavioral Physiology, 2012
A double-blind trial in 600 patients with grade I, II, and III chronic cerebral ischemia demonstrated the high clinical efficacy of Cytoflavin, an antioxidant and energy corrector, at a dose of two tablets twice daily for 25 days, as compared with a placebo.
Z. A. Suslina   +8 more
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