Results 101 to 110 of about 2,901,268 (383)

Lactobacillus reuteri DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial

Nutrients, 2020
The main objective was to assess the efficacy of a probiotic (Lactobacillus reuteri DSM 17938), a prebiotic (agave inulin), and a synbiotic on the stool characteristics in children with cerebral palsy and chronic constipation.
A. G. Contreras, Edgar M Vásquez Garibay, C. A. S. Ramírez, Mary Fafutis Morris, Vidal Delgado Rizo   +4 more
semanticscholar   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Positive association between the neutrophil percentage-to-albumin ratio and constipation: a retrospective cross-sectional study

Frontiers in Medicine
IntroductionThe neutrophil-to-albumin ratio (NPAR), a novel marker of systemic inflammation, has been utilized to predict outcomes in patients with cancer and cardiovascular diseases.
Yuping Shu, Zuqing Chen, Minyuan Lu, Nai Mi, Yong Wan, Wei Shen, Zewei Sheng, Zewei Sheng, Hongwu Tao, Xuefeng Liu, Xuefeng Liu, Yuedong Liu   +11 more
doaj   +1 more source

Functional bowel disease : a challenging frontier in gastroenterology [PDF]

, 1999
The last 30 years have seen incredible advances in the science and practice of gastroenterology and hepatology. In the 1970s, the fiberoptic endoscopic revolution facilitated the visualization of the mucosa of a large segment of the gastrointestinal ...
Camilleri, Michael
core  

Medication use by early-stage breast cancer survivors: a 1-year longitudinal study. [PDF]

, 2016
PurposeThe aim of this study is to characterize the patterns of medication use by early-stage breast cancer (ESBC) survivors from diagnosis to 1 year post-chemotherapy.MethodsA single-center longitudinal study was conducted with ESBC patients diagnosed ...
Chan, Alexandre, Lee, Chee Ping, Loh, Kep Yong, Ng, Raymond, Ng, Terence   +4 more
core   +1 more source

Expanding criteria for slow colonic transit in patients being evaluated for chronic constipation by scintigraphy

Neurogastroenterology and Motility, 2020
Colonic transit measurement [geometric center (GC) at 24 and 48 hours] identifies slow transit constipation (STC) in patients with chronic constipation.
Katayoun Khoshbin, I. Busciglio, D. Burton, M. Breen-Lyles, M. Camilleri   +4 more
semanticscholar   +1 more source

Iptacopan for Immune Thrombocytopenia and Cold Agglutinin Disease: A Global Phase 2 Basket Clinical Trial

American Journal of Hematology, EarlyView.
ABSTRACT Iptacopan is a first‐in‐class, oral, selective inhibitor of complement factor B that has demonstrated positive efficacy across several complement‐driven diseases. Here we evaluate the efficacy and safety of iptacopan monotherapy in adult patients with primary immune thrombocytopenia (ITP) and primary cold agglutinin disease (CAD). We performed
Alexander Röth, Wilma Barcellini, Christine Ademokun, Junho Jang, Maria Luisa Lozano, David Valcarcel Ferreiras, Cristina Pascual‐Izquierdo, Shripad Chitnis, Sofiya Matviykiv, Alessandra Vitaliti, Chi Chen, Vasiliki Katsanou, Raghav Chawla, Hanny Al‐Samkari   +13 more
wiley   +1 more source

No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury

Annals of Clinical and Translational Neurology, 2023
Background Opioids effectively reduce chronic pain, but present significant side effects including opioid‐induced constipation. Oxycodone/naloxone decreases pain and constipation in cancer patients, however its effect on spinal cord injury population ...
Rahul Sachdeva, Ali Hosseinzadeh, Aaron Rizzardo, Andrea Maharaj, Michael Berger, Andrei Krassioukov   +5 more
doaj   +1 more source

The Irritable Bowel Syndrome [PDF]

, 2009
A 45 year old businessman presents at your clinic with a 2 year history of recurrent abdominal pain, associated with frequent bouts of diarrhoea. The pain is relieved by defaecation, but there is often a feeling of incomplete evacuation.
Zammit, Edward
core  

An OGT Missense Variant With Impaired Enzyme Activity in a Child With Severe Developmental Delay and Hepatoblastoma

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT O‐GlcNAc transferase (OGT) and its antagonist O‐GlcNAcase (OGA) regulate protein O‐GlcNAcylation, a highly conserved post‐translational modification involved in metabolic sensing. Pathogenic variants in the OGT gene cause an X‐linked congenital disorder of glycosylation (OGT‐CDG) presenting developmental delay, hypotonia, intellectual ...
Alfonso Manuel D'Alessio, Huijie Yuan, Leandro Raul Soria, Sara Basse Hansen, Iolanda Boffa, Paola Arena, Benedetta Attianese, Maureen. O'Sullivan, Noelle Cullinan, Lewis Pang, Daan Marinus Ferdinand van Aalten, Nicola Brunetti‐Pierri, Sally Ann Lynch   +12 more
wiley   +1 more source