Results 81 to 90 of about 92,292 (242)

Patient‐Reported Outcomes with Selpercatinib Treatment Among Patients with RET‐Mutant Medullary Thyroid Cancer in the Phase I/II LIBRETTO‐001 Trial

open access: yesThe Oncologist, EarlyView., 2021
Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth   +10 more
wiley   +1 more source

Investigating the Quality of Sleep in Patients with Functional Constipation Referred to Shahid Mostafa Khomini Hospital in Ilam [PDF]

open access: yesIranian South Medical Journal
Background: Constipation is a very common disorder in adults. The aim of this study is to determine the relationship between sleep hours during the week and weekends with constipation in individuals.
Gholamreza Nouri   +3 more
doaj  

Clinical trial of safety and antitumor activity of farletuzumab ecteribulin in patients with platinum‐resistant ovarian cancer: Phase I expansion results

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective In the dose‐escalation part of Study 101, which included multiple tumor types, objective responses were observed in 10 of 22 patients across multiple dose levels of farletuzumab ecteribulin (FZEC). We explored the safety/antitumor activity of FZEC in patients with platinum‐resistant ovarian cancer (PROC) from the Study 101 expansion ...
Kan Yonemori   +11 more
wiley   +1 more source

Association between visceral adiposity index and bowel habits and inflammatory bowel disease: a cross-sectional study

open access: yesScientific Reports
Obesity has become a global public health problem, and its relationship with gastrointestinal diseases has become a major concern. The visceral adiposity index (VAI) is a novel index to assess the distribution and content of visceral fat, and this study ...
Xiaoxian Yang   +7 more
doaj   +1 more source

Pelvic venous disorders in women: Diagnosis and management for gynecologists

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Pelvic venous disorders (PeVD) are an underrecognized yet significant cause of chronic pelvic pain (CPP) in reproductive‐aged women, characterized by venous reflux, obstruction, or both. This clinical opinion provides a practical overview of PeVD for gynecologists, outlining its pathophysiology, common presentations, diagnostic approach, and ...
Tiffany Ni   +5 more
wiley   +1 more source

Randomized Double-blind Controlled Trial: Benefits of Lactobacillus reuteri in Chronic Functional Constipation Patients

open access: yesThe Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2015
Background: Chronic functional constipation is a common problem that affects between 15-25% of the population and cause symptoms and disorders that creates discomfort, morbidity, and high costs for health care.
Taolin Agustinus   +3 more
doaj  

Randomized controlled trial protocol to analyze the effects of rice with different contents of resistant starch on chronic constipation

open access: yesScientific Reports
The trend of the aging population worldwide is becoming increasingly severe. As people age, constipation becomes increasingly common in older adults, causing varying degrees of physical and psychological harm to them.
Yiping Zhao   +5 more
doaj   +1 more source

Chronic constipation: focus on microbiome-targeted therapies with prebiotics, probiotics, and synbiotics

open access: yesAlʹmanah Kliničeskoj Mediciny
Chronic constipation is a global medical, social, and economic problem due to its negative impact on patients’ quality of life and increased risk of colorectal cancer, cardiovascular and cerebrovascular disorders. The gut microbiota plays an important
Margarita Y. Serkova   +2 more
doaj   +1 more source

Evaluating the Diagnostic Utility of Spinal Ultrasound in Neonates With a Simple Sacral Dimple: An Eight‐Year Retrospective Study

open access: yesJournal of Medical Radiation Sciences, EarlyView.
This study retrospectively analysed eight years of neonatal spinal ultrasound data from a major Australian children's hospital to assess the value of imaging for simple sacral dimples. Out of 448 scans, 195 were for an isolated simple dimple, and only two infants (1%) were found to have spinal dysraphism, both with other congenital anomalies.
Nyles Tattersall   +5 more
wiley   +1 more source

MODERN VIEWS ON A PROBLEM OF CONSTIPATION IN CHILDREN — A POSITION OF PEDIATRICIANS

open access: yesПедиатрическая фармакология, 2009
This article highlights the issues of definition and classification of chronic constipation, the most prevailing pathology among gastrointestinal tract diseases.
F.Ch. Shakhtakhtinskaya
doaj   +2 more sources

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