Results 91 to 100 of about 1,695,181 (246)

Chronic cough as a novel phenotype of chronic obstructive pulmonary disease

, 2018
Hyeon-Kyoung Koo,1 Sung-Woo Park,2 Jeong-Woong Park,3 Hye Sook Choi,4 Tae-Hyung Kim,5 Hyoung Kyu Yoon,6 Kwang Ha Yoo,7 Ki-Suck Jung,8 Deog Kyeom Kim9 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital,
Kim TH, Koo HK, Park JW, Jung KS, Choi HS, Park SW, Yoo KH, Yoon HK, Kim DK   +8 more
core  

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

Voice problems in chronic cough: prevalence and implications for health and sick leave in a Northern European population

BMC Pulmonary Medicine
Background Voice problems have been reported in individuals with chronic cough, but population-based prevalence data are not yet available. While both conditions independently affect health and sick leave, their combined effects have not been studied ...
Sofia Ögefeldt, Greta Öhlund Wistbacka, Ellika Schalling, Henrik Johansson, Andrei Malinovschi, Christer Janson, Lars Modig, Mathias Holm, Rain Jögi, Christine Cramer, Thorarinn Gislason, Ane Johannessen, Össur Ingi Emilsson   +12 more
doaj   +1 more source

Cerebellar ataxia, neuropathy and vestibular areflexia syndrome: a neurogenic cough prototype

ERJ Open Research
Chronic cough is a frequent disorder that is defined by cough of more than 8 weeks duration. Despite extensive investigation, some patients exhibit no aetiology and others do not respond to specific treatments directed against apparent causes of cough ...
Laurent Guilleminault, Stuart B. Mazzone, Pauline Chazelas, Simon Frachet, Anne-Sophie Lia, Laurent Magy   +5 more
doaj   +1 more source

Cough severity visual analog scale scores and quality of life in patients with refractory or unexplained chronic cough.

20.500.12530/87858Refractory chronic cough (RCC) and unexplained chronic cough (UCC) adversely affect patients' quality of life (QoL). This multicenter, non-interventional study evaluates the relationship between cough severity and QoL and other patient ...
Jareño MS,, Arismendi, Ebymar, Quirce S,, González-Barcala, Francisco Javier, López-Cotarelo, Pilar, Sánchez-Jareño, Marta, Puente-Maestu, Luis, Pérez de Llano, Luis, López-Cotarelo, P, González-Barcala FJ,, Dávila, Ignacio, Domingo C,, Arismendi E,, Crespo-Lessman A,, De Diego, Alfredo, Cea-Calvo, Luis, Quirce, Santiago, Crespo-Lessman, Astrid, Pérez de Llano L,, Cea-Calvo L,, Domingo, Christian, Puente Maestu, Luis, Dávila I,, De Diego A,   +23 more
core   +1 more source

The impact of chronic cough: a cross-sectional European survey [PDF]

, 2015
PURPOSE: Studies that investigate the impact of chronic cough have largely focused on patients attending secondary care. Our aim was to investigate the opinions of the wider general population across Europe. METHODS: An internet survey was made available

core   +1 more source

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

Cough in Children and Adults: Diagnosis, Assessment and Management (CICADA). Summary of an updated position statement on chronic cough in Australia (Letter)

To the Editor: The recent publication in this Journal of the position statement summary on cough in children and adults is welcome and timely.1 Much has changed in the understanding of chronic cough since the last Australian guideline was published in ...
Birring, S, Turner, R
core   +1 more source

Mathematical modeling of the spread of the coronavirus under strict social restrictions

Mathematical Methods in the Applied Sciences, EarlyView., 2021
We formulate a simple susceptible‐infectious‐recovery (SIR) model to describe the spread of the coronavirus under strict social restrictions. The transmission rate in this model is exponentially decreasing with time. We find a formula for basic reproduction function and estimate the maximum number of daily infected individuals.
Mo'tassem Al‐arydah, Hailay Berhe, Khalid Dib, Kalyanasundaram Madhu   +3 more
wiley   +1 more source

Implementation of guideline‐recommended medical therapy for patients with heart failure in Europe

ESC Heart Failure, Volume 12, Issue 2, Page 790-798, April 2025.
Abstract Physicians' adherence to guideline‐recommended heart failure (HF) treatment remains suboptimal, especially regarding the target doses. In particular, there is evidence that non‐cardiologists are less compliant with HF guideline recommendations. This is likely to have a detrimental impact on patients' survival, readmissions and quality of life.
Maurizio Volterrani, Petar Seferovic, Gianluigi Savarese, Ilaria Spoletini, Egidio Imbalzano, Antoni Bayes‐Genis, Ewa Jankowska, Michele Senni, Marco Metra, Ovidiu Chioncel, Andrew J. S. Coats, Giuseppe M. C. Rosano   +11 more
wiley   +1 more source