Results 1 to 10 of about 27,993 (176)

Cough desensitization treatment for patients with refractory chronic cough: results of a second pilot randomized control trial [PDF]

BMC Pulmonary Medicine, 2023
Objective The purpose of this study was to collect pilot efficacy data on a novel treatment for refractory chronic cough (RCC), which we call cough desensitization treatment (CDT).
Laurie J. Slovarp, Jane E. Reynolds, Sophia Tolbert, Sarah Campbell, Shannon Welby, Paige Morkrid   +5 more
doaj   +2 more sources

Psychological profile of individuals presenting with chronic cough [PDF]

ERJ Open Research, 2017
Chronic refractory cough (CRC) is a common problem in respiratory clinics. Adverse effects on quality of life are documented in the literature, but relatively little is known about the underlying psychological factors in this patient population. We aimed
Katrin Hulme, Vincent Deary, Sian Dogan, Sean M. Parker   +3 more
doaj   +4 more sources

The P2X3 receptor antagonist filapixant in patients with refractory chronic cough: a randomized controlled trial [PDF]

Respiratory Research, 2023
Background P2X3 receptor antagonists seem to have a promising potential for treating patients with refractory chronic cough. In this double-blind, randomized, placebo-controlled study, we investigated the efficacy, safety, and tolerability of the novel ...
Christian Friedrich, Klaus Francke, Surinder S. Birring, Jan Willem K. van den Berg, Paul A. Marsden, Lorcan McGarvey, Alice M. Turner, Pascal Wielders, Isabella Gashaw, Stefan Klein, Alyn H. Morice   +10 more
doaj   +2 more sources

A double-blind randomised placebo-controlled trial investigating the effects of lesogaberan on the objective cough frequency and capsaicin-evoked coughs in patients with refractory chronic cough [PDF]

ERJ Open Research, 2022
Objective Baclofen is a centrally acting γ-aminobutyric acid type B (GABAB) receptor agonist which reduces gastro-oesophageal reflux and suppresses the cough reflex; however, central nervous system side-effects limit its use.
Huda Badri, Carmen Gibbard, Dimitra Denton, Imran Satia, Bashar Al-Sheklly, Rachel J. Dockry, Kimberley Holt, Kevin McGuiness, Sam Treadway, Peter Whorwell, Lesley Houghton, Augustine Lee, K. Jane Escott, Theresa Lee, Greame Wilkinson, Alison Holt, Brendan J. Canning, Jacky A. Smith   +17 more
doaj   +2 more sources

Reframing Refractory Chronic Cough: The Role of Interoception. [PDF]

Lung
Refractory chronic cough (RCC) remains a persistent clinical challenge, often resistant to traditional treatments. Emerging evidence now positions RCC as a disorder rooted in hypersensitivity, driven primarily by central neural processes rather than external physiological causes. Central to this understanding is the concept of interoception-the brain's
Slovarp LJ, Reynolds JE, Gillespie AI, Jetté ME.   +3 more
europepmc   +3 more sources

An observational study to understand burden and cost of care in adults diagnosed with refractory chronic cough (RCC) or unexplained chronic cough (UCC) [PDF]

Respiratory Research
Background Refractory and unexplained chronic cough (RCC and UCC) necessitate frequent referral for specialist evaluations, but data on healthcare resource utilisation and costs are lacking.
Jaclyn A. Smith, Norman Stein, Sylwia Migas, Sue Bokowski, Claire Williams, Patricia Baker, John New, Jonathan Schelfhout, Eileen Fonseca, Haya Langerman   +9 more
doaj   +2 more sources

New Insights Into Refractory Chronic Cough and Unexplained Chronic Cough: A 6-Year Ambispective Cohort Study. [PDF]

Allergy Asthma Immunol Res, 2023
Only limited studies have depicted the unique features and management of refractory chronic cough (RCC) and unexplained chronic cough (UCC). These led to the initiation of this study, which reported the demographic characteristics, manifestations, and long-term outcomes on a large series of consecutive RCC/UCC patients, providing a guideline-led real ...
Zhang M, Morice AH, Si F, Zhang L, Chen Q, Wang S, Zhu Y, Xu X, Yu L, Qiu Z.   +9 more
europepmc   +4 more sources

Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency [PDF]

ERJ Open Research
Background Treatment of chronic cough remains a challenge. We hypothesised that inhaled alkaline hypertonic divalent salts (alkaline HDS) might provide relief for refractory chronic cough by laryngeal and tracheal hydration.
Hisham Abubakar-Waziri, David A. Edwards, Deen Bhandu Bhatta, James H. Hull, Matthew Rudd, Peter Small, Kian Fan Chung   +6 more
doaj   +2 more sources

Nonpharmacological cough control therapy for chronic refractory cough and cough associated with underlying lung disease [PDF]

ERJ Open Research, 2020
Nonpharmacological cough control therapy (CCT) is effective for refractory chronic cough but there is a significant subgroup of nonresponders. CCT appears to be effective in cough associated with underlying disease such as asthma. http://bit.ly/2uCCwu3.
Sana Mohammed, John Steer, Jenny Ellis, Sean M. Parker   +3 more
doaj   +3 more sources

Female predominance in chronic cough: biological sex–related factors, mechanisms, and therapeutic targets—a narrative review [PDF]

Frontiers in Medicine
Chronic cough—defined in adults as cough lasting ≥8 weeks—shows higher prevalence in women. Accumulating evidence supports a cough hypersensitivity phenotype with peripheral and central drivers that may vary by biological sex.
Aibo Zheng, Kai Sun, Wenjun Li, Zhiyu Chen, Yuting Li, Wei Wu, Jie Gan   +6 more
doaj   +2 more sources