Heliyon, 2023 Chronic cough is common in the clinic and can seriously affect the quality of life of patients. Following the existing guidelines for treatment, refractory chronic cough is defined as a clinical condition in which the cause of the cough remains unclear ...
Yanzi Peng +4 more
doaj +4 more sources
ATP, an Attractive Target for the Treatment of Refractory Chronic Cough [PDF]
Purinergic Signalling, 2022 Chronic cough is the most common complaint in respiratory clinics. Most of them have identifiable causes and some may respond to common disease-modifying therapies.
Alyn H Morice, Mengru Zhang
exaly +4 more sources
Cough desensitization treatment for patients with refractory chronic cough: results of a second pilot randomized control trial [PDF]
BMC Pulmonary Medicine, 2023 Objective The purpose of this study was to collect pilot efficacy data on a novel treatment for refractory chronic cough (RCC), which we call cough desensitization treatment (CDT).
Laurie J. Slovarp +5 more
doaj +2 more sources
The P2X3 receptor antagonist filapixant in patients with refractory chronic cough: a randomized controlled trial [PDF]
Respiratory Research, 2023 Background P2X3 receptor antagonists seem to have a promising potential for treating patients with refractory chronic cough. In this double-blind, randomized, placebo-controlled study, we investigated the efficacy, safety, and tolerability of the novel ...
Christian Friedrich +10 more
doaj +2 more sources
An observational study to understand burden and cost of care in adults diagnosed with refractory chronic cough (RCC) or unexplained chronic cough (UCC) [PDF]
Respiratory ResearchBackground Refractory and unexplained chronic cough (RCC and UCC) necessitate frequent referral for specialist evaluations, but data on healthcare resource utilisation and costs are lacking.
Jaclyn A. Smith +9 more
doaj +2 more sources
Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency [PDF]
ERJ Open ResearchBackground Treatment of chronic cough remains a challenge. We hypothesised that inhaled alkaline hypertonic divalent salts (alkaline HDS) might provide relief for refractory chronic cough by laryngeal and tracheal hydration.
Hisham Abubakar-Waziri +6 more
doaj +2 more sources
Cough Desensitization Treatment: A Randomized, Sham-Controlled Pilot Trial for Patients With Refractory Chronic Cough [PDF]
Respiratory Medicine, 2022 Laurie Slovarp, Paige Morkrid
exaly +2 more sources
EClinicalMedicine, 2023 Summary: Background: Recently we identified in patients with chronic cough a sensory dysregulation via which the urge-to-cough (UTC) or coughing are evoked mechanically from “somatic points for cough” (SPCs) in the neck and upper trunk.
Federico Lavorini +7 more
doaj +1 more source
Non-pharmacological Management of Non-productive Chronic Cough in Adults: A Systematic Review
Frontiers in Rehabilitation Sciences, 2022 BackgroundChronic cough is a common reason for medical referral and its prevalence is on the rise. With only one pharmaceutical therapy currently under review for the treatment of refractory chronic cough, exploring non-pharmacological chronic cough ...
Ana Maria Ilicic +14 more
doaj +1 more source
From bench to bedside: The role of cough hypersensitivity in chronic cough
Clinical and Translational Medicine, 2023 Background Chronic cough is a burdensome condition characterized by persistent cough lasting longer than 8 weeks. Chronic cough can significantly affect quality of life, physical function and productivity, with many people troubled with a cough that ...
Matthew G. Drake +2 more
doaj +1 more source