Heliyon, 2023 Chronic cough is common in the clinic and can seriously affect the quality of life of patients. Following the existing guidelines for treatment, refractory chronic cough is defined as a clinical condition in which the cause of the cough remains unclear ...
Yanzi Peng +4 more
doaj +4 more sources
Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency [PDF]
ERJ Open ResearchBackground Treatment of chronic cough remains a challenge. We hypothesised that inhaled alkaline hypertonic divalent salts (alkaline HDS) might provide relief for refractory chronic cough by laryngeal and tracheal hydration.
Hisham Abubakar-Waziri +6 more
doaj +3 more sources
Cough desensitization treatment for patients with refractory chronic cough: results of a second pilot randomized control trial [PDF]
BMC Pulmonary Medicine, 2023 Objective The purpose of this study was to collect pilot efficacy data on a novel treatment for refractory chronic cough (RCC), which we call cough desensitization treatment (CDT).
Laurie J. Slovarp +5 more
doaj +2 more sources
The P2X3 receptor antagonist filapixant in patients with refractory chronic cough: a randomized controlled trial [PDF]
Respiratory Research, 2023 Background P2X3 receptor antagonists seem to have a promising potential for treating patients with refractory chronic cough. In this double-blind, randomized, placebo-controlled study, we investigated the efficacy, safety, and tolerability of the novel ...
Christian Friedrich +10 more
doaj +2 more sources
Reframing Refractory Chronic Cough: The Role of Interoception. [PDF]
LungRefractory chronic cough (RCC) remains a persistent clinical challenge, often resistant to traditional treatments. Emerging evidence now positions RCC as a disorder rooted in hypersensitivity, driven primarily by central neural processes rather than external physiological causes. Central to this understanding is the concept of interoception-the brain's
Slovarp LJ +3 more
europepmc +3 more sources
An observational study to understand burden and cost of care in adults diagnosed with refractory chronic cough (RCC) or unexplained chronic cough (UCC) [PDF]
Respiratory ResearchBackground Refractory and unexplained chronic cough (RCC and UCC) necessitate frequent referral for specialist evaluations, but data on healthcare resource utilisation and costs are lacking.
Jaclyn A. Smith +9 more
doaj +2 more sources
A double-blind randomised placebo-controlled trial investigating the effects of lesogaberan on the objective cough frequency and capsaicin-evoked coughs in patients with refractory chronic cough [PDF]
ERJ Open Research, 2022 Objective Baclofen is a centrally acting γ-aminobutyric acid type B (GABAB) receptor agonist which reduces gastro-oesophageal reflux and suppresses the cough reflex; however, central nervous system side-effects limit its use.
Huda Badri +17 more
doaj +2 more sources
Prevalence of refractory and unexplained chronic cough in adults treated in cough centre
ERJ Open ResearchBackground Refractory chronic cough and unexplained chronic cough pose significant clinical challenges, impairing patients’ quality of life. However, a precise definition of refractory chronic cough remains elusive.
Paweł Kukiełka +4 more
doaj +3 more sources
Effectiveness of virtual, group cough modulation therapy for chronic refractory cough
ERJ Open ResearchChronic refractory cough is common. A virtual, group-based approach that delivers cough suppression therapy was associated with improvements in cough severity visual analogue scale and Leicester cough questionnaire scores. https://bit.ly/4ltwNul.
Emily C. Kear +8 more
doaj +3 more sources
Initial Success: Camlipixant in Refractory Chronic Cough. [PDF]
Am J Respir Crit Care MedRui Y, Chen Z.
europepmc +3 more sources