Results 1 to 10 of about 17,290 (146)

Gabapentin for refractory chronic cough [PDF]

Lancet, The, 2013
www.thelancet.com Vol 381 February 23, 2013 623 Submissions should be made via our electronic submission system at http://ees.elsevier.com/ thelancet/ pneumonia. Indeed, in our outpatient clinics in Yaita (Tochigi Prefecture) and Kashiwa (Chiba Prefecture), about 20% of patients complaining of persistent cough between June and October, 2012, were ...
Ken-Ichiro Inoue
exaly   +9 more sources

Cough desensitization treatment for patients with refractory chronic cough: results of a second pilot randomized control trial [PDF]

BMC Pulmonary Medicine, 2023
Objective The purpose of this study was to collect pilot efficacy data on a novel treatment for refractory chronic cough (RCC), which we call cough desensitization treatment (CDT).
Laurie J. Slovarp, Jane E. Reynolds, Sophia Tolbert, Sarah Campbell, Shannon Welby, Paige Morkrid   +5 more
doaj   +2 more sources

Management of non-pharmacologic therapy for chronic refractory cough: Mechanism, composition, applicable population, and assessment

Heliyon, 2023
Chronic cough is common in the clinic and can seriously affect the quality of life of patients. Following the existing guidelines for treatment, refractory chronic cough is defined as a clinical condition in which the cause of the cough remains unclear ...
Yanzi Peng, Tongyanzi Zhang, Lingdan Yuan, Xianghuai Xu, Li Yu   +4 more
doaj   +3 more sources

The P2X3 receptor antagonist filapixant in patients with refractory chronic cough: a randomized controlled trial [PDF]

Respiratory Research, 2023
Background P2X3 receptor antagonists seem to have a promising potential for treating patients with refractory chronic cough. In this double-blind, randomized, placebo-controlled study, we investigated the efficacy, safety, and tolerability of the novel ...
Christian Friedrich, Klaus Francke, Surinder S. Birring, Jan Willem K. van den Berg, Paul A. Marsden, Lorcan McGarvey, Alice M. Turner, Pascal Wielders, Isabella Gashaw, Stefan Klein, Alyn H. Morice   +10 more
doaj   +2 more sources

A double-blind randomised placebo-controlled trial investigating the effects of lesogaberan on the objective cough frequency and capsaicin-evoked coughs in patients with refractory chronic cough [PDF]

ERJ Open Research, 2022
Objective Baclofen is a centrally acting γ-aminobutyric acid type B (GABAB) receptor agonist which reduces gastro-oesophageal reflux and suppresses the cough reflex; however, central nervous system side-effects limit its use.
Huda Badri, Carmen Gibbard, Dimitra Denton, Imran Satia, Bashar Al-Sheklly, Rachel J. Dockry, Kimberley Holt, Kevin McGuiness, Sam Treadway, Peter Whorwell, Lesley Houghton, Augustine Lee, K. Jane Escott, Theresa Lee, Greame Wilkinson, Alison Holt, Brendan J. Canning, Jacky A. Smith   +17 more
doaj   +2 more sources

An observational study to understand burden and cost of care in adults diagnosed with refractory chronic cough (RCC) or unexplained chronic cough (UCC) [PDF]

Respiratory Research
Background Refractory and unexplained chronic cough (RCC and UCC) necessitate frequent referral for specialist evaluations, but data on healthcare resource utilisation and costs are lacking.
Jaclyn A. Smith, Norman Stein, Sylwia Migas, Sue Bokowski, Claire Williams, Patricia Baker, John New, Jonathan Schelfhout, Eileen Fonseca, Haya Langerman   +9 more
doaj   +2 more sources

Reframing Refractory Chronic Cough: The Role of Interoception. [PDF]

Lung
Refractory chronic cough (RCC) remains a persistent clinical challenge, often resistant to traditional treatments. Emerging evidence now positions RCC as a disorder rooted in hypersensitivity, driven primarily by central neural processes rather than external physiological causes. Central to this understanding is the concept of interoception-the brain's
Slovarp LJ, Reynolds JE, Gillespie AI, Jetté ME.   +3 more
europepmc   +3 more sources

Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency [PDF]

ERJ Open Research
Background Treatment of chronic cough remains a challenge. We hypothesised that inhaled alkaline hypertonic divalent salts (alkaline HDS) might provide relief for refractory chronic cough by laryngeal and tracheal hydration.
Hisham Abubakar-Waziri, David A. Edwards, Deen Bhandu Bhatta, James H. Hull, Matthew Rudd, Peter Small, Kian Fan Chung   +6 more
doaj   +2 more sources

Prevalence of refractory and unexplained chronic cough in adults treated in cough centre

ERJ Open Research
Background Refractory chronic cough and unexplained chronic cough pose significant clinical challenges, impairing patients’ quality of life. However, a precise definition of refractory chronic cough remains elusive.
Paweł Kukiełka, Katarzyna Moliszewska, Katarzyna Białek-Gosk, Elżbieta M. Grabczak, Marta Dąbrowska   +4 more
doaj   +3 more sources

Gabapentin for chronic refractory cough: A system review and meta-analysis

Heliyon, 2023
Objective: To evaluate the efficacy and safety of gabapentin in the treatment of chronic refractory cough by Meta-Analysis. Methods: Literatures were retrieved from PubMed, Embase (OvidIP), Cochrane Library, CNKI, VIP, Wanfang Database and China ...
Sheng Xie, Meiling Xie, Yongchun Shen, Deyun Cheng   +3 more
doaj   +3 more sources