Results 11 to 20 of about 1,855,208 (237)

ATP, an attractive target for the treatment of refractory chronic cough [PDF]

Purinergic Signalling, 2022
Chronic cough is the most common complaint in respiratory clinics. Most of them have identifiable causes and some may respond to common disease-modifying therapies.
Zhang Mengru, Laura Sadofsky, Dominic Sykes   +2 more
exaly   +4 more sources

Impaired cough suppression in chronic refractory cough [PDF]

European Respiratory Journal, 2019
Functional brain imaging in individuals with chronic cough demonstrates reduced activation in cortical regions associated with voluntary cough suppression. Little is known about the ability of patients with chronic cough to suppress cough. This study aimed to compare the ability to voluntarily suppress cough during inhaled capsaicin challenge in ...
Peter S.P. Cho, Hannah V. Fletcher, Richard D. Turner, Caroline J. Jolley, Surinder S. Birring   +4 more
openaire   +6 more sources

Management of chronic refractory cough in adults [PDF]

European Journal of Internal Medicine, 2020
Cough is a common respiratory symptom that is considered to be chronic when it lasts more than eight weeks. When severe, chronic cough may significantly impact an individual's quality of life, and such patients are frequently referred for specialist evaluation.
Visca D., Beghe' B., Fabbri L. M., Papi A., Spanevello A.   +4 more
openaire   +5 more sources

Efficacy of Gefapixant, a P2X3 Antagonist, for Refractory Atopic Cough

International Medical Case Reports Journal, 2023
Yoshihisa Ishiura, Shosaku Nomura, Yuka Ishii, Kai Imai, Yusuke Sawai, Takeshi Tamaki, Toshiki Shimizu, Naoyuki Miyashita, Tomoki Ito First Department of Internal Medicine, Kansai Medical University, Osaka, JapanCorrespondence: Yoshihisa Ishiura, First ...
Ishiura Y, Nomura S, Ishii Y, Imai K, Sawai Y, Tamaki T, Shimizu T, Miyashita N, Ito T   +8 more
doaj   +1 more source

Camlipixant in Refractory Chronic Cough: A Phase 2b, Randomized, Placebo-controlled Trial (SOOTHE) [PDF]

American Journal of Respiratory and Critical Care Medicine
Rationale: There is no broadly accessible treatment for patients with refractory chronic cough, a disease characterized by chronic cough that persists despite treatment for other cough-related etiologies or has no identified underlying cause ...
Margaret Garin, Michael S Blaiss
exaly   +4 more sources

Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial

ERJ Open Research, 2023
Background: Cough is the most reported symptom in the United States, with chronic refractory cough representing significant morbidity to patients. Zinc acetate may have beneficial effects in the cough reflex pathway.
Aparna Balasubramanian, Janet T. Holbrook, Brendan J. Canning, Loretta G. Que, Mario Castro, Barry J. Make, Linda Rogers, Michael F. Busk, Alexis Rea, Ashley A. McCook-Veal, Jiaxian He, Meredith C. McCormack, Robert A. Wise   +12 more
doaj   +2 more sources

Managing patients with chronic cough: challenges and solutions

Therapeutics and Clinical Risk Management, 2018
Jeanne-Marie Perotin,1,2 Claire Launois,1 Maxime Dewolf,1 Antoine Dumazet,1 Sandra Dury,1 François Lebargy,1 Valérian Dormoy,2 Gaëtan Deslee1,2 1Department of Respiratory Diseases, University Hospital of Reims, Reims, France; 2INSERM ...
Perotin JM, Launois C, Dewolf M, Dumazet A, Dury S, Lebargy F, Dormoy V, Deslee G   +7 more
doaj   +1 more source

Real-world usage and response to gefapixant in refractory chronic cough

ERJ Open Research
Background The real-world efficacy of the P2X3 antagonist gefapixant, a new class of antitussive for refractory chronic cough, is not yet fully understood.
Hisako Matsumoto, Yoshihiro Kanemitsu, Motoki Ohe, Hiroshi Tanaka, Kunihiko Terada, Koichi Nishi, Ryo Atsuta, Johsuke Hara, Junpei Saito, Mitsuhide Ohmichi, Tamotsu Ishizuka, Teruaki Nishiuma, Hideki Inoue, Naoto Watanabe, Tatsuya Nagano, Tetsuya Ueda, Haruhiko Ogawa, Shigeru Endo, Takeshi Suzuki, Toshiyuki Kita, Katsuya Fujimori, Yoshihisa Ishiura, Masaki Fujimura, Akio Niimi   +23 more
doaj   +2 more sources

Gabapentin for refractory chronic cough [PDF]

The Lancet, 2013
www.thelancet.com Vol 381 February 23, 2013 623 Submissions should be made via our electronic submission system at http://ees.elsevier.com/ thelancet/ pneumonia. Indeed, in our outpatient clinics in Yaita (Tochigi Prefecture) and Kashiwa (Chiba Prefecture), about 20% of patients complaining of persistent cough between June and October, 2012, were ...
James P, Brown, Angshu, Bhowmik
  +9 more sources

Cough desensitization treatment: A randomized, sham-controlled pilot trial for patients with refractory chronic cough [PDF]

Respiratory Medicine, 2022
Laurie Slovarp
exaly   +2 more sources