The development of the Cough Hypersensitivity Questionnaire for chronic cough [PDF]
ERJ Open ResearchIntroduction Chronic cough is considered a disorder of neuronal hypersensitivity in which patients frequently report abnormal laryngeal and chest sensations, and excessive triggers.
Barnaby Hirons +11 more
doaj +7 more sources
From bench to bedside: The role of cough hypersensitivity in chronic cough [PDF]
Clinical and Translational Medicine, 2023 Background Chronic cough is a burdensome condition characterized by persistent cough lasting longer than 8 weeks. Chronic cough can significantly affect quality of life, physical function and productivity, with many people troubled with a cough that ...
Matthew G. Drake +2 more
doaj +8 more sources
Could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough? [PDF]
ERJ Open ResearchBackground Recently, cough reflex hypersensitivity has been proposed as a common underlying feature of chronic cough in adults. However, symptoms and clinical characteristics of cough hypersensitivity have not been studied amongst phenotypes of chronic ...
Mi-Yeong Kim +23 more
doaj +3 more sources
Activation of Adenosine Triphosphate-Gated Purinergic 2 Receptor Channels by Transient Receptor Potential Vanilloid Subtype 4 in Cough Hypersensitivity [PDF]
BiomoleculesBackground: Transient receptor potential vanilloid subtype 4 (TRPV4) is a Ca2+-permeable non-selective cation channel that is involved in the development of cough hypersensitivity. Purinergic 2 receptors (P2X) belong to a class of adenosine triphosphate (
Xianghuai Xu, Wanzhen Li, Shengyuan Wang
exaly +4 more sources
Association of Cough Hypersensitivity With Tracheal TRPV1 Activation and Neurogenic Inflammation in a Novel Guinea Pig Model of Citric Acid-Induced Chronic Cough [PDF]
Journal of International Medical Research, 2018 Objective This study was performed to establish a novel model of citric acid-induced chronic cough in guinea pigs and to investigate the pathogenesis of cough hypersensitivity.
Li Yu, Hanjing Lu, Zhongmin Qiu
exaly +3 more sources
Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough [PDF]
Respiratory Research, 2019 Background The differential sensitivity of cough to antitussive therapies implies the existence of heterogeneity in cough hypersensitivity, but how such heterogeneity is expressed across individual patients is poorly understood.
Li Long +10 more
doaj +2 more sources
Long-term nitric oxide exposure induces cough hypersensitivity via non-inflammatory activation of the HIF1α–TRPV1 pathway [PDF]
Frontiers in PharmacologyBackgroundChronic cough hypersensitivity is common across respiratory diseases and often occurs without airway inflammation, yet effective treatments remain limited.
Jingxin Zhao +9 more
doaj +2 more sources
From respiratory viral infection to persistent cough hypersensitivity: neuroimmune regulation and therapeutic implications of P2X3/TRP ion-channel targets [PDF]
Frontiers in PharmacologyRespiratory viral infections are increasingly recognized as important drivers of persistent airway symptoms and exacerbations in chronic lung disease. Post-infectious cough (PIC), particularly after upper respiratory tract infection, represents one of ...
Borui Li +6 more
doaj +2 more sources
The therapeutic effects of labetalol in chronic stress- and immuno-agonist-induced cough hypersensitivity and lung inflammation involve reducing interferon-γ-producing T lymphocytes [PDF]
ERJ Open ResearchBackground Psychological stress correlates with chronic cough, which is often triggered by respiratory viruses. Chronic stress promotes sympathetic nerves to release norepinephrine and neuropeptide Y.
Tongtong Song +7 more
doaj +2 more sources
Substance P–expressing neurons in the hypothalamic paraventricular nucleus mediate chronic cough hypersensitivity via the hypothalamus–airway neural pathway [PDF]
Frontiers in NeuroscienceBackground and purposeIncreased cough sensitivity is the key pathophysiological mechanism of chronic cough. Although previous studies have focused on peripheral airway receptor sensitization, the role of the central nervous system—particularly the ...
Xiaoyan Zhang +7 more
doaj +2 more sources