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Cough Hypersensitivity Syndrome: Why Its Use Is Inappropriate in Children [PDF]

Journal of Clinical Medicine, 2023
In children and adults, chronic cough is a common symptom presenting to health professionals worldwide. It is internationally accepted that children with chronic cough should be managed with pediatric specific management guidelines. The newly proposed clinical entity of ‘cough hypersensitivity syndrome’ has gained significant attention in adult ...
Anne B Chang, Ahmad Kantar, Hannah E O'Farrell   +2 more
exaly   +9 more sources

Chronic Cough Hypersensitivity Syndrome [PDF]

Cough, 2013
Chronic cough has been suggested to be due to three conditions, asthma, post nasal drip, and reflux disease. A different paradigm has evolved in which cough is viewed as the primary condition characterised by afferent neuronal hypersensitivity and different aspects of this syndrome are manifest in the different phenotypes of cough.
Alyn H Morice
exaly   +8 more sources

Clarifying Terminology in Chronic Cough: The Evolving Role of Cough Hypersensitivity Syndrome [PDF]

The Clinical Respiratory Journal
Chronic cough is defined as a cough lasting no less than 8 weeks, and 10%–42% of patients with chronic cough retain their cough after comprehensive examination and treatment.
Zihang Wang, Yaxing Zhou, Yingchun Ren, Jiaying Yuan, Tongyangzi Zhang, Shengyuan Wang, Wanzhen Li, Li Yu, Xianghuai Xu   +8 more
doaj   +3 more sources

Postoperative exacerbated cough hypersensitivity syndrome induces dramatic respiratory alkalosis, lactatemia, and electrolyte imbalance [PDF]

BMC Anesthesiology
Background The perioperative management of patients with chronic cough or cough hypersensitivity syndrome and its sometimes severe effects is currently under-researched and under-reported.
Sascha Jan Baettig, Raluca Ruxandra Fend, Daniel Gero, Christian Gutschow, Martin Schlaepfer   +4 more
doaj   +6 more sources

The Genetic Architecture of Chronic Cough: From Sensory Hypersensitivity to Treatable Trait [PDF]

Pulmonary Therapy
Chronic cough is a prevalent global clinical disorder with substantial quality-of-life impairment, and refractory cases remain a major unmet medical need.
Ran Dong, Mengru Zhang, Alyn H. Morice
doaj   +2 more sources

Unraveling the neuro-immune axis in cough hypersensitivity: from pathogenesis to synergistic management [PDF]

Frontiers in Medicine
Cough Hypersensitivity Syndrome (CHS) stands as the definitive pathological phenotype of refractory chronic cough, characterized by a sensory nervous system that over-reacts to even trivial, low-threshold stimuli.
Dingyi Shi, Dingyi Shi, Jia He, Jia He, Yajing Huang, Yajing Huang, Lisha Liu, Yunna Li, Yunna Li, Qi Liu, Qi Liu, Shunlin Peng, Shunlin Peng   +12 more
doaj   +2 more sources

From respiratory viral infection to persistent cough hypersensitivity: neuroimmune regulation and therapeutic implications of P2X3/TRP ion-channel targets [PDF]

Frontiers in Pharmacology
Respiratory viral infections are increasingly recognized as important drivers of persistent airway symptoms and exacerbations in chronic lung disease. Post-infectious cough (PIC), particularly after upper respiratory tract infection, represents one of ...
Borui Li, Ziyang Yu, Fanshuai Zeng, Xiaotian Jiang, Haotian Xi, Kun Wang, Lixiu Zhang   +6 more
doaj   +2 more sources

Mechanoinflammation: mechanosensing and inflammatory amplification through the airway macrophage Piezo1–NLRP3 axis in cough-variant asthma [PDF]

Frontiers in Immunology
Cough-variant asthma (CVA) is characterized by chronic dry cough as its predominant manifestation, lacking the wheezing typical of classic asthma. Violent paroxysmal coughing generates distinct mechanical loads across different airway segments: the ...
Suping Yu, Suping Yu, Xianqing Ren, Xianqing Ren, Ying Ding, Ying Ding, Yan Xu, Yan Xu, Mengmeng Sun, Mengmeng Sun, Guichun Zhang, Guichun Zhang, Bingxue Zhang, Bingxue Zhang, Qiongqiong Xing, Qiongqiong Xing, Guihua Song, Guihua Song, Haitao Wang, Haitao Wang   +19 more
doaj   +2 more sources

Skin hypersensitivity in chronic cough patients: symptom profiles and psychosomatic correlates [PDF]

Annals of Medicine
Background Cough hypersensitivity syndrome (CHS) is a characteristic of patients with chronic cough (CC). Sensitive skin syndrome (SSS), which is characterised by cutaneous pain and pruritus, may share neural hypersensitivity mechanisms with CHS.
Tongyangzi Zhang, Heng Wu, Haodong Bai, Jiguang Wu, Lili Zhang, Rongrong Li, Yiqing Zhu, Bingxian Sha, Jiaying Yuan, Yaxing Zhou, Xianghuai Xu, Li Yu   +11 more
doaj   +2 more sources

ATP–P2X3 Signaling as a Shared Neural Sensitization Pathway in Endometriosis and Irritable Bowel Syndrome: Mechanisms and Therapeutic Implications [PDF]

Biomedicines
Endometriosis and irritable bowel syndrome (IBS) are chronic pain disorders that frequently coexist and share key pathophysiological features, including neuroinflammation, visceral hypersensitivity, peripheral sensitization, and central sensitization ...
My Anh Duong, Prakash V. A. K. Ramdass
doaj   +2 more sources