Results 1 to 10 of about 1,333,073 (194)
ATP P2X3 receptors and neuronal sensitization [PDF]
Frontiers in Cellular Neuroscience, 2013 Increasing evidence indicates the importance of extracellular ATP in the modulation of neuronal function. In particular, fine control of ATP release and the selective and discrete ATP receptor operation are crucial elements of the crosstalk between ...
Elsa eFabbretti
doaj +5 more sources
Unusually strong temperature dependence of P2X3 receptor traffic to the plasma membrane [PDF]
Frontiers in Cellular Neuroscience, 2011 ATP-gated P2X3 receptors are expressed by nociceptive neurons and participate in transduction of pain. Responsiveness of P2X3 receptors is strongly enhanced at high temperatures, suggesting a role for these receptors in temperature detection.
Evgeny ePryazhnikov +4 more
doaj +4 more sources
P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications [PDF]
Frontiers in Pharmacology, 2021 Andrea Spinaci +5 more
doaj +4 more sources
Neurotropin alleviates rat osteocarcinoma pain via P2X3 receptor activation in the midbrain periaqueductal gray [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Clinically effective analgesia treatment for patients afflicted with osteocarcinoma lessens the intensity of pain. The midbrain periaqueductal gray (PAG) plays a critical role in pain modulation, and activation of P2X3 receptors in this ...
Xingfeng Liu, Jingxin He, Zhi Xiao
doaj +2 more sources
DESENSITIZATION PROPERTIES OF P2X3 RECEPTORS SHAPING PAIN SIGNALLING [PDF]
Frontiers in Cellular Neuroscience, 2013 ATP-gated P2X3 receptors are mostly expressed by nociceptive sensory neurons and participate in transduction of pain signals. P2X3 receptors show a combination of fast desensitization onset and slow recovery.
Rashid eGiniatullin, Andrea eNistri
doaj +4 more sources
P2X3 Receptor Antagonist in Chronic Cough [PDF]
Lancet, The, 2015 244 www.thelancet.com Vol 386 July 18, 2015 of an underlying cough trigger” such as “refl ux disease, asthma, and postnasal drip”. However, 25% of patients had a productive cough, and patients with a forced expiratory volume in 1 s to forced vital capacity ratio less than 70% (the accepted defi nition for COPD) were included.
Richard D Turner +2 more
exaly +5 more sources
Role of ATP in migraine mechanisms: focus on P2X3 receptors
The Journal of Headache and Pain, 2023 Migraine is a major health burden worldwide with complex pathophysiology and multifarious underlying mechanisms. One poorly understood issue concerns the early steps in the generation of migraine pain.
R. Giniatullin, A. Nistri
doaj +3 more sources
Computational and Structural Biotechnology Journal, 2022 Gefapixant/AF-219, a selective inhibitor of the P2X3 receptor, is the first new drug other than dextromethorphan to be approved for the treatment of refractory chronic cough (RCC) in nearly 60 years.
Wen-Wen Cui +13 more
doaj +1 more source
Molecular Pain, 2021 Peripheral inflammatory and neuropathic pain are closely related to the activation of purinergic receptor P2X ligand-gated ion channel 3 (P2X3) and transient receptor potential vanilloid 1 (TRPV1), but the interaction between P2X3 and TRPV1 in different ...
Jie Yu +7 more
doaj +1 more source
Frontiers in Physiology, 2022 Background: Clinical investigation indicates a high level of co-morbidity between bladder overactivity and irritable bowel syndrome. The cross-sensitization of afferent pathways has been demonstrated to be the main reason for the cross-organ ...
XingYou Dong +5 more
doaj +1 more source