Results 31 to 40 of about 1,333,073 (194)

Brain Natriuretic Peptide Constitutively Downregulates P2X3 Receptors by Controlling their Phosphorylation State and Membrane Localization

Molecular Pain, 2015
Background ATP-gated P2X3 receptors are important transducers of nociceptive stimuli and are almost exclusively expressed by sensory ganglion neurons. In mouse trigeminal ganglion (TG), P2X3 receptor function is unexpectedly enhanced by pharmacological ...
Anna Marchenkova, Sandra Vilotti, Elsa Fabbretti, Andrea Nistri   +3 more
doaj   +1 more source

Mutated Ca2.1 Channels Dysregulate CASK/P2X3 Signaling in Mouse Trigeminal Sensory Neurons of R192Q Cacna1a Knock-in Mice

Molecular Pain, 2013
Background ATP-gated P2X3 receptors of sensory ganglion neurons are important transducers of pain as they adapt their expression and function in response to acute and chronic nociceptive signals.
Aswini Gnanasekaran, Tanja Bele, Swathi Hullugundi, Manuela Simonetti, Michael D Ferrari, Arn MJM van den Maagdenberg, Andrea Nistri, Elsa Fabbretti   +7 more
doaj   +1 more source

Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse model

Molecular Pain, 2011
Background A genetic knock-in mouse model expressing the R192Q mutation of the α1-subunit of the CaV2.1 channels frequently found in patients with familial hemiplegic migraine shows functional upregulation of ATP-sensitive P2X3 receptors of trigeminal ...
Fabbretti Elsa, van den Maagdenberg Arn MJM, Sundukova Mayya, Gnanasekaran Aswini, Nistri Andrea   +4 more
doaj   +1 more source

P2x3-receptor desensitization as an alternative mechanism of analgesia [PDF]

Fiziolohichnyĭ zhurnal, 2013
One of the most important current medical problems is the synthesis of substances that could suppress pathological pain. It has not been yet invented any method for chronic pain inhibition. Chronic pain is largely mediated by the activation of purinergic P2X3- and P2X2/3-receptors.
N S, Petrenko, O O, Kryshtal'
openaire   +2 more sources

Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine

Molecular Pain, 2016
Background On trigeminal ganglion neurons, pain-sensing P2X3 receptors are constitutively inhibited by brain natriuretic peptide via its natriuretic peptide receptor-A. This inhibition is associated with increased P2X3 serine phosphorylation and receptor
Anna Marchenkova PhD, Sandra Vilotti PhD, Niels Ntamati MS, Arn MJM van den Maagdenberg PhD, Andrea Nistri MD   +4 more
doaj   +1 more source

Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies [PDF]

Journal of Biological Chemistry, 2016
Purinergic homomeric P2X3 and heteromeric P2X2/3 receptors are ligand-gated cation channels activated by ATP. Both receptors are predominantly expressed in nociceptive sensory neurons, and an increase in extracellular ATP concentration under pathological conditions, such as tissue damage or visceral distension, induces channel opening, membrane ...
Shcherbatko, Anatoly, Foletti, Davide, Poulsen, Kris, Strop, Pavel, Zhu, Guoyun, Hasa-Moreno, Adela, Melton Witt, Jody, Loo, Carole, Krimm, Stellanie, Pios, Ariel, Yu, Jessica, Brown, Colleen, Lee, John K, Stroud, Robert, Rajpal, Arvind, Shelton, David   +15 more
openaire   +4 more sources

Polyphyllin VI screened from Chonglou by cell membrane immobilized chromatography relieves inflammatory pain by inhibiting inflammation and normalizing the expression of P2X3 purinoceptor

Frontiers in Pharmacology, 2023
Objective: Inflammatory pain is one of the most common diseases in daily life and clinic. In this work, we analysed bioactive components of the traditional Chinese medicine Chonglou and studied mechanisms of their analgesic effects.Material and methods ...
Zhenhui Luo, Zhenhui Luo, Tingting Wang, Tingting Wang, Zhenglang Zhang, Zhenglang Zhang, Hekun Zeng, Hekun Zeng, Mengqin Yi, Mengqin Yi, Peiyang Li, Peiyang Li, Jiaqin Pan, Jiaqin Pan, Chunyan Zhu, Na Lin, Shangdong Liang, Alexei Verkhratsky, Hong Nie, Hong Nie   +19 more
doaj   +1 more source

P2X3 Receptor in Primary Afferent Neurons Mediates the Relief of Visceral Hypersensitivity by Electroacupuncture in an Irritable Bowel Syndrome Rat Model

Gastroenterology Research and Practice, 2020
Background. Electroacupuncture (EA) has been confirmed effectiveness in the treatment of irritable bowel syndrome (IBS), and P2X3 receptors in the peripheral and central neurons participate in the acupuncture-mediated relief of the visceral pain in IBS ...
Fang Zhang, Zhe Ma, Zhijun Weng, Min Zhao, Handan Zheng, Luyi Wu, Yuan Lu, Chunhui Bao, Yanan Liu, Huirong Liu, Huangan Wu   +10 more
doaj   +1 more source

P2X3 receptor: a novel ‘CASKade’ of signaling?

Journal of Neurochemistry, 2013
Read the full article ‘Calcium/calmodulin‐dependent serine protein kinase (CASK) is a new intracellular modulator of P2X3 receptors’ on doi: 10.1111/jnc ...
Volonté C, Burnstock G
openaire   +3 more sources

Distribution of P2X3 receptors in the rat trigeminal ganglion after inferior alveolar nerve injury

, 1998
The ATP-gated cation channel receptor P2X3 is associated with nociceptive primary sensory neurons. We have, using immunohistochemistry, examined the expression of P2X3 in rat trigeminal ganglia 4–22 days after ligation/section or chronic constriction of ...
Matthews, T., Eriksson, J., Kidd, Emma Jane, Bongenhielm, U., Fried, K., J Eriksson, Eriksson, J, Fried, K,, U Bongenhielm, B Matthews, Bongenhielm, U, Matthews, T, K Fried, E Kidd, Kidd, E   +14 more
core   +1 more source