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Purinergic Signalling: Therapeutic Developments [PDF]

Frontiers in Pharmacology, 2017
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990’s when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Geoffrey Burnstock
doaj   +3 more sources

Ventilatory and Carotid Body Chemoreceptor Responses to Purinergic P2X Receptor Antagonists in Newborn Rats

Journal of Applied Physiology, 2011
Adenosine triphosphate, acting through purinergic P2X receptors, has been shown to stimulate ventilation and increase carotid body chemoreceptor activity in adult rats. However, its role during postnatal development of the ventilatory response to hypoxia is yet unknown.
Aida Bairam, Vincent Joseph, David F Donnelly   +2 more
exaly   +4 more sources

P2X Receptors: Potential Therapeutic Targets for Symptoms Associated With Lung Cancer — A Mini Review

Frontiers in Oncology, 2021
Symptoms associated with lung cancer mainly consist of cancer-associated pain, cough, fatigue, and dyspnea. However, underlying mechanisms of lung cancer symptom clusters remain unclear.
Yonglin Mai, Zhihua Guo, Weiqiang Yin, Nanshan Zhong, Peter V. Dicpinigaitis, Ruchong Chen   +5 more
doaj   +1 more source

Synthesis, Biological Evaluation and Molecular Modeling Studies of Naphthoquinone Sulfonamides and Sulfonate Ester Derivatives as P2X7 Inhibitors

Molecules, 2023
ATP acts in the extracellular environment as an important signal, activating a family of receptors called purinergic receptors. In recent years, interest in the potential therapeutics of purinergic components, including agonists and antagonists of ...
Paulo Anastácio Furtado Pacheco, Daniel Tadeu Gomes Gonzaga, Natalia Lidmar von Ranke, Carlos Rangel Rodrigues, David Rodrigues da Rocha, Fernando de Carvalho da Silva, Vitor Francisco Ferreira, Robson Xavier Faria   +7 more
doaj   +1 more source

P2X Purinergic Receptor Antagonist Accelerates SkinBarrier Repair and Prevents Epidermal Hyperplasia Inducedby Skin Barrier Disruption [PDF]

Journal of Investigative Dermatology, 2002
The effects of ATP receptor agonists/antagonists on skin barrier recovery rate were evaluated in hairless mice. Topical application of ATP and alpha,beta-methylene ATP (agonist of P2X receptor) delayed barrier recovery. Topical application of suramin (nonspecific ATP receptor antagonist), pyridoxal-phosphate-6-azophenyl-2',4'-disulfonic acid (PPADS ...
Denda, Mitsuhiro, Inoue, Kaori, Fuziwara, Shigeyoshi, Denda, Sumiko   +3 more
openaire   +2 more sources

Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival [PDF]

Diabetologia, 2009
In obesity, beta cells activate compensatory mechanisms to adapt to the higher insulin demand. Interleukin-1 receptor antagonist (IL-1Ra) prevents obesity-induced hyperglycaemia and is a potent target for the treatment of diabetes, but the mechanisms of its secretion and regulation in obesity are unknown.
Glas, R., Sauter, N. S., Schulthess, F. T., Shu, L., Oberholzer, J., Maedler, K.   +5 more
openaire   +4 more sources

P2X7 Receptors in Neurodegeneration: Potential Therapeutic Applications From Basic to Clinical Approaches

Frontiers in Cellular Neuroscience, 2021
Purinergic receptors play important roles in central nervous system (CNS), where the bulk of these receptors are implicated in neuroinflammatory responses and regulation of cellular function of neurons, microglial and astrocytes.
Paul R. Territo, Paul R. Territo, Hamideh Zarrinmayeh   +2 more
doaj   +1 more source

Systematic analyses of the sequence conservation and ligand interaction patterns of purinergic P1 and P2Y receptors provide a structural basis for receptor selectivity

Computational and Structural Biotechnology Journal, 2023
Purinergic receptors are membrane proteins that regulate numerous cellular functions by catalyzing reactions involving purine nucleotides or nucleosides.
Ri Han, Hongryul Yoon, Jiho Yoo, Yoonji Lee   +3 more
doaj   +1 more source

Extracellular Adenosine Diphosphate Ribose Mobilizes Intracellular Ca2+ via Purinergic-Dependent Ca2+ Pathways in Rat Pulmonary Artery Smooth Muscle Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Adenosine diphosphate ribose (ADPR), a product of β-NAD+ metabolism generated by the multifunctional enzyme CD38, is recognized as a novel signaling molecule. The catalytic site of CD38 orients extracellularly or intracellularly, capable
Chun Huang, Jinxing Hu, Krishna P. Subedi, Amanda H.Y. Lin, Omkar Paudel, Pixin Ran, James S.K. Sham   +6 more
doaj   +1 more source

P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology

Frontiers in Pharmacology, 2017
Adenosine 5′-triphosphate is a well-known extracellular signaling molecule and neurotransmitter known to activate purinergic P2X receptors. Information has been elucidated about the structure and gating of P2X channels following the determination of the ...
Leanne Stokes, Leanne Stokes, Janice A. Layhadi, Lucka Bibic, Kshitija Dhuna, Samuel J. Fountain   +5 more
doaj   +1 more source