Results 21 to 30 of about 1,391,718 (154)

P2 Receptors as Therapeutic Targets in the Salivary Gland: From Physiology to Dysfunction

Frontiers in Pharmacology, 2020
Although often overlooked in our daily lives, saliva performs a host of necessary physiological functions, including lubricating and protecting the oral cavity, facilitating taste sensation and digestion and maintaining tooth enamel.
Mahmoud G. Khalafalla, Mahmoud G. Khalafalla, Mahmoud G. Khalafalla, Lucas T. Woods, Lucas T. Woods, Kimberly J. Jasmer, Kimberly J. Jasmer, Kevin Muñoz Forti, Kevin Muñoz Forti, Jean M. Camden, Jean M. Camden, Janicke L. Jensen, Kirsten H. Limesand, Hilde K. Galtung, Gary A. Weisman, Gary A. Weisman   +15 more
doaj   +1 more source

Hemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors

Virulence, 2018
Epsilon-toxin (ETX) is produced by types B and D strains of Clostridium perfringens, which cause fatal enterotoxaemia in sheep, goats and cattle. Previous studies showed that only a restricted number of cell lines are sensitive to ETX and ETX-induced ...
Jie Gao, Wenwen Xin, Jing Huang, Bin Ji, Shan Gao, Liang Chen, Lin Kang, Hao Yang, Xin Shen, Baohua Zhao, Jinglin Wang   +10 more
doaj   +1 more source

Differential Expression of the Metabotropic P2Y Receptor Family in the Cortex Following Status Epilepticus and Neuroprotection via P2Y1 Antagonism in Mice

Frontiers in Pharmacology, 2020
Purinergic signaling via P2 receptors is now widely accepted to play a critical role during increased states of hyperexcitability and seizure-induced pathology.
Mariana Alves, Jonathon Smith, Jonathon Smith, Tobias Engel, Tobias Engel   +4 more
doaj   +1 more source

Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]

, 2014
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin (407627), Philip G Haydon, Ulyana Lalo (506296), Yuriy Pankratov, Seyed Rasooli-Nejad (506297), Rasooli-Nejad, Seyed, Yuriy Pankratov (407630), Oleg Palygin, Ulyana Lalo, Haydon, Philip G., Jemma Andrew, Jemma Andrew (506298), Philip G. Haydon (506299), Andrew, Jemma, Seyed Rasooli-Nejad, Pankratov Yuriy, Lalo Ulyana, Andrew Jemma, Palygin Oleg, Rasooli-Nejad Seyed, Haydon Philip G.   +23 more
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Coexpression of rat P2X2 and P2X6 subunits in Xenopus oocytes. [PDF]

, 2000
Transcripts for P2X(2) and P2X(6) subunits are present in rat CNS and frequently colocalize in the same brainstem nuclei. When rat P2X(2) (rP2X(2)) and rat P2X(6) (rP2X(6)) receptors were expressed individually in Xenopus oocytes and studied under ...
B. F. King, Burnstock, G., Wildman, Scott S.P., Townsend-Nicholson, A., Spyer, K. M., King, B F, A. Townsend-Nicholson, Thomas, T., G. Burnstock, Wildman, S. S., Thomas, T, King, B. F., Townsend-Nicholson, A, Burnstock, G, S. S. Wildman, Spyer, K M, T. Thomas, K. M. Spyer   +17 more
core   +1 more source

An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels

Frontiers in Cellular Neuroscience, 2019
P2X receptors constitute a gene family of cation channels gated by extracellular ATP. They mediate fast ionotropic purinergic signaling in neurons and non-excitable cell types in vertebrates.
Ariel R. Ase, Éric Therrien, Philippe Séguéla   +2 more
doaj   +1 more source

Emerging key roles for P2X receptors in the kidney [PDF]

, 2013
P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides.
Peppiatt-Wildman, Claire M., Peppiatt-Wildman, C. M., Wildman, S. S., R. E. Birch, C. M. Peppiatt-Wildman, Scott S Wildman, Schwiebert, E. M., Wildman, Scott S.P., E. M. Schwiebert, S. S. Wildman, Birch, R. E.   +10 more
core   +1 more source

P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]

, 2008
When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
King, Brian F., Wildman, Scott S.P.
core   +1 more source

Radioligands Targeting the Purinergic P2X Receptors

Cells
Purinergic P2X receptors have a wide distribution within the body and modulate a number of physiological processes, being also involved in the development and progression of inflammation-, neuroinflammation-, neurodegeneration-, and cancer-related ...
Diego Dal Ben, Michela Buccioni, Catia Lambertucci, Beatrice Francucci, Aleksei Smirnov, Andrea Spinaci, Gabriella Marucci, Rosaria Volpini   +7 more
doaj   +1 more source

P2X receptors: Insights from the study of the domestic dog [PDF]

, 2023
Fifty years ago, the late Geoffrey Burnstock described the concept of purinergic nerves and transmission bringing into existence the broader concepts of purinergic signaling including P2X receptors.
Reece A Sophocleous (20268162), Ronald Sluyter (543341), Leanne Stokes (543342)   +2 more
core   +2 more sources