Results 21 to 30 of about 1,333,073 (194)
Mechanisms underlying purinergic P2X3 receptor-mediated mechanical allodynia induced in diabetic rats [PDF]
Molecular Pain, 2011 Background Diabetic neuropathy is a common neuropathy associated with paresthaesia and pain. The mechanisms underlying the painful conditions are not well understood.
Xu Guang-Yin +3 more
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Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP [PDF]
eLife, 2019 P2X3 receptor channels expressed in sensory neurons are activated by extracellular ATP and serve important roles in nociception and sensory hypersensitization, making them attractive therapeutic targets.
Mufeng Li +7 more
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Geoffery Burnstock’s influence on the evolution of P2X3 receptor pharmacology [PDF]
Purinergic Signalling, 2020 I first met Geoffery Burnstock in 1985 while working as a young post-doctoral fellow for Michael Williams at CIBA-Geigy Corporation. During that time, we were researching the role of adenosine in stroke and cardiovascular disease. These research efforts crystallized into a drug discovery program aimed at developing selective adenosine receptor agonists
Jarvis MF.
openaire +4 more sources
Piezo1-pannexin-1-P2X3 axis in odontoblasts and neurons mediates sensory transduction in dentinal sensitivity [PDF]
Frontiers in Physiology, 2022 According to the “hydrodynamic theory,” dentinal pain or sensitivity is caused by dentinal fluid movement following the application of various stimuli to the dentin surface.
Sadao Ohyama +17 more
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Where Eastern Medicine Meets Western Medicine: A World Review of the Management of Chronic Cough [PDF]
World J Otorhinolaryngol Head Neck SurgABSTRACT Purpose To summarize current Western and Eastern approaches to the evaluation and management of chronic cough, with particular emphasis on etiology‐directed therapy, cough hypersensitivity, behavioral interventions, neuromodulators, procedural treatments, and traditional remedies.
Teng T +5 more
europepmc +2 more sources
Journal of Dental Sciences, 2022 Sex differences in the nervous system have gained recent academic interest. While the prominent differences are observed in mood and anxiety disorders, growing number of evidences also suggest sex difference in pain perception.
Seon-Hong Seol, Gehoon Chung
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ATP–P2X3 Signaling as a Shared Neural Sensitization Pathway in Endometriosis and Irritable Bowel Syndrome: Mechanisms and Therapeutic Implications [PDF]
BiomedicinesEndometriosis and irritable bowel syndrome (IBS) are chronic pain disorders that frequently coexist and share key pathophysiological features, including neuroinflammation, visceral hypersensitivity, peripheral sensitization, and central sensitization ...
My Anh Duong, Prakash V. A. K. Ramdass
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Role of P2X3 receptor in dorsal root ganglion in colitis-induced bladder overactivity
Di-san junyi daxue xuebao, 2021 Objective To investigate the role of P2X3 receptor in dorsal root ganglion (DRG) in bladder micturition function due to colitis-induced bladder dysfunction in the rat model of 2, 4, 6-trinitrosulfonic acid (TNBS)-induced colitis.
YANG Yang +8 more
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Frontiers in Immunology, 2022 Previous studies have demonstrated that acute colonic inflammation leads to an increase in dorsal root ganglia (DRG) neuronal excitability. However, the signaling elements implicated in this hyperexcitability have yet to be fully unraveled. Extracellular
Eduardo E. Valdez-Morales +7 more
doaj +1 more source
PLoS ONE, 2013 A knock-in (KI) mouse model of FHM-1 expressing the R192Q missense mutation of the Cacna1a gene coding for the α1 subunit of CaV2.1 channels shows, at the level of the trigeminal ganglion, selective functional up-regulation of ATP -gated P2X3 receptors ...
Swathi K Hullugundi +3 more
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