Results 41 to 50 of about 1,333,073 (194)

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Geoffrey Burnstock, Burnstock, G, Burnstock Geoffrey   +2 more
core   +1 more source

Modulation of P2X3 receptors by spider toxins

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012
Recently, the novel peptide named purotoxin-1 (PT1) has been identified in the venom of the spider Geolycosa sp. and shown to exert marked modulatory effects on P2X3 receptors in rat sensory neurons. Here we studied another polypeptide from the same spider venom, purotoxin-2 (PT2), and demonstrated that it also affected activity of mammalian P2X3 ...
Kabanova, Natalia V., Vassilevski, Alexander A., Rogachevskaja, Olga A., Bystrova, Marina F., Korolkova, Yuliya V., Pluzhnikov, Kirill A., Romanov, Roman A., Grishin, Eugene V., Kolesnikov, Stanislav S.   +8 more
openaire   +2 more sources

A role for the purinergic receptor P2X3 in astrocytes in the mechanism of craniofacial neuropathic pain

, 2017
The purinergic receptor P2X3, expressed in the central terminals of primary nociceptive neurons in the brainstem, plays an important role in pathological pain.
C. Justin Lee, Yong Chul Bae, Jaekwang Lee, Jin Sook Ju, Jin Young Bae, Dong Kuk Ahn, Sang Man Lee, Won Mah   +7 more
core   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Purinergic receptor expression in neuronal, bladder smooth muscle and urothelial cells: characterization and inhibition by low molecular weight antagonists [PDF]

, 2009
P2 purinoceptors comprise ionotropic (P2X) and metabotropic (P2Y) receptor families, responsive to nucleotide ligands and diversely distributed on virtually every mammalian cell. Most cells and tissues co-express multiple subtypes of purinoceptor; thus,
Gever, J.L.
core  

PRDM16 is necessary for sensory neuronal development and differentiation in the trigeminal ganglion

Developmental Dynamics, EarlyView.
Abstract Background Cranial neural crest cells (cNCC) generate craniofacial cartilage, bone, and peripheral neurons and glia, and birth defects arise when the cartilage/neuronal/glial progenitors fail to differentiate. PRDM16 is a transcriptional regulator containing both zinc‐finger and SET domains, implicated in craniofacial development and orofacial
Fahmida Raha, Qiman Gao, Lomeli C. Shull, Kristin B. Artinger   +3 more
wiley   +1 more source

Calcium/calmodulin-dependent serine protein kinase (CASK) is a new intracellular modulator of P2X3 receptors

, 2013
ATP-gated P2X3 receptors of sensory ganglion neurons are important transducers of painful stimuli and are modulated by extracellular algogenic substances, via changes in the receptor phosphorylation state.
Gnanasekaran, A, Hullugundi, S, Birsa, N, Hseuh, Y. P, Bianchini, G, Fabbretti, E., Nistri, Andrea, Sundukova, M   +7 more
core   +1 more source

P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP

, 2005
Extracellular ATP plays a role in nociceptive signaling and sensory regulation of visceral function through ionotropic receptors variably composed of P2X2 and P2X3 subunits.
Knight, G E, Yip, P, McMahon, S B, Rong, W, Dunn, P M, Zhong, Y, Ma, B, Nunn, P, Burnstock, G, Ruan, H Z, Cockayne, D A, Ford, A P, Hamilton, S G   +12 more
core   +2 more sources

Laryngeal Cryotherapy for Neurogenic Cough: Safety, Feasibility, and Prospective Outcomes

The Laryngoscope, EarlyView.
A prospective clinical trial investigated the safety and clinical outcomes of office‐based selective laryngeal cryotherapy for patients with refractory chronic cough. Patient were followed for 6 months posttreatment and had durable improvement in cough severity index and urge‐to‐cough scores and no serious long term adverse effects.
Shumon I. Dhar, Eric Allen, Yun‐Lun Liu, Alexandra D. D'Oto, Rishi Suresh, Adrianna Shembel, Ted Mau   +6 more
wiley   +1 more source

Subtype-specific regulation of P2X3 and P2X2/3 receptors by phosphoinositides in peripheral nociceptors

Molecular Pain, 2009
Background P2X3 and P2X2/3 purinergic receptor-channels, expressed in primary sensory neurons that mediate nociception, have been implicated in neuropathic and inflammatory pain responses.
Logothetis Diomedes, Ase Ariel R, Chabot-Doré Anne-Julie, Zhao Qi, Bernier Louis-Philippe, Mo Gary, Cao Chang-Qing, Séguéla Philippe   +7 more
doaj   +1 more source