Results 61 to 70 of about 1,333,073 (194)
International Endodontic Journal, EarlyView.ABSTRACT Objectives Mechanical and/or microbial stimuli can prompt extracellular ATP release in many cell types, where it acts as an inflammatory mediator to amplify pain signals and inflammation. This study aimed to investigate the synergistic effects of microbial and/or mechanical stimulation on ATP and cytokine release from dental pulp cells (DPCs ...
Orla M. Dunne +4 more
wiley +1 more source
Generierung und Charakterisierung transgener BAC-P2X3-Mäuse [PDF]
, 2013 To examine the expression of the P2X3 receptor interest to the development of chronic neuropathic and inflammatory pain, the aim of this work was the generation of a BAC transgenic P2X3-EGFP-reporter mouse and the subsequent characterisation of the P2X3 ...
Günther, Janka
core
One Mean Gene: How P2X3 Makes Asthma Worse in Women [PDF]
, 2021 Kee\u27s research involves mast cells, the primary immune cell involved with asthma and allergies. Her research shows that IL33 elicits an ATP release acting on the P2X3 receptor hypothesized only to be present females, creating a feed-forward loop ...
Kee, Ann
core
Experimental Physiology, EarlyView.Abstract Sympathetic nervous system activation is a hallmark of high‐altitude hypoxia, yet the afferent mechanisms remain incompletely defined. We examined the relative contributions of pulmonary arterial mechanoreceptors and carotid chemoreceptors – two excitatory pathways co‐activated by hypoxia – to sustained sympathoexcitation at altitude.
Michiel T. Ewalts +13 more
wiley +1 more source
, 1997 Of the cloned P2X receptor subunits, six are expressed in sensory neurons, suggesting that the native channels may be heteromultimers with diverse composition. It has been proposed that P2X2 and P2X3 form heteromultimers in sensory neurons.
M.S. Riedl +13 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil +11 more
wiley +1 more source
High‐altitude headache: Insights into pathophysiology and potential treatment implications
The Journal of Physiology, EarlyView.Abstract figure legend High‐altitude headache occurs during prolonged exposure to low oxygen, such as during ascent to high altitude. Several risk factors increase its likelihood, with the degree of hypoxia, often driven by rapid ascent to greater altitudes, being the most prominent factor.
Marika Falla +3 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen +7 more
wiley +1 more source
Deletion of P2X2 and P2X3 receptor subunits does not alter motility of the mouse colon
Frontiers in Neuroscience, 2010 Purinergic P2X receptors contribute to neurotransmission in the gut. P2X receptors are ligand-gated cation channels that mediate synaptic excitation in subsets of enteric neurons.
Matthew DeVries +3 more
doaj +1 more source
Pregabalin Efficacy in Treatment of Chronic Neurogenic Cough
The Laryngoscope, Volume 136, Issue 11, Page 4938-4944, November 2026.The use of neuromodulators for chronic cough has increased; however, the choice of medication, dosing regimen, and duration are still unclear. This longitudinal study of 95 adults taking pregabalin, 75 mg twice daily, for CNC demonstrated 78% improvement or resolution of cough, 17% unchanged, 1% worse cough, with a mean of 6 weeks of therapy, and only ...
Jacqui Allen +3 more
wiley +1 more source