Results 71 to 80 of about 1,333,073 (194)
Effect of TNFα on P2X3 receptor activity and co-expression of its TNFR2 receptors.
, 2013 A, Examples of TNFR2 and P2X3 co-exexpression in (wildtype) WT and R192Q (knockin) KI neurons. Left panel shows P2X3 expression (green), and right panel shows TNFR2 staining (red).
Michel D. Ferrari (103728) +3 more
core +1 more source
Neuropathic Pain: From Mechanisms to Therapeutic Interventions
MedComm, Volume 7, Issue 10, October 2026.Neuropathic pain arises from peripheral nerve injury, central sensitization, neurotransmitter imbalance, neuroimmune activation, and maladaptive circuit remodeling. Clinical phenotyping and multimodal imaging can identify dominant peripheral and central mechanisms.
Yaling Dai +8 more
wiley +1 more source
Pharmaceutical Biology, 2019 Context: Notopterygium incisum Ting ex H. T. Chang (Umbelliferae) (NI) specializes in treatment of upper limb rheumatoid arthritis (RA), but the exact mechanism is unclear. P2Xs are useful targets for inflammatory pain therapy.
Yinghao Wang +5 more
doaj +1 more source
ATP Release and Purinergic Signaling Potentiate β‐Adrenergic Effects on Brown Adipocytes
Acta Physiologica, Volume 242, Issue 10, October 2026.ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Marco Tozzi +8 more
wiley +1 more source
, 2007 Spinorphin, an endogenous antinociceptive peptide (LVVYPWT), showed potent and non-competitive antagonism at the ATP-activated human P2X3 receptor (IC50 = 8.3 pM) in a two-electrode voltage clamp assay with recombinant human P2X3 receptors expressed in ...
Jung, Kwan-Young +5 more
core +1 more source
Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley +1 more source
Agonist Antagonist Interactions at the Rapidly Desensitizing P2X3 Receptor
PLoS ONE, 2013 P2X3 receptors (P2XRs), as members of the purine receptor family, are deeply involved in chronic pain sensation and therefore, specific, competitive antagonists are of great interest for perspective pain management. Heretofore, Schild plot analysis has been commonly used for studying the interaction of competitive antagonists and the corresponding ...
Nick Helms +3 more
openaire +4 more sources
Postnatal developmental changes in the laryngeal chemosensory cell clusters of rats
Journal of Anatomy, Volume 249, Issue 4, Page 769-786, October 2026.Chemosensory cell clusters appeared in the rat larynx 2 days after birth and were already connected to afferent nerve fibers. Their number increased until 3 weeks of age, then stabilized while continuing to grow through the addition of new cells. Because their number reached a plateau around the time of weaning, their development may be linked to ...
Sayed Sharif Abdali +5 more
wiley +1 more source
Pharmacological characterization of novel ligands of P2X3 receptor
, 2017 Charles University Faculty of Pharmacy in Hradec Králové Department of pharmacology and toxicology Student: Daulet Balmagambetov Supervisors: Prof. Dr. Christa Elisabeth Müller Dr. Aliaa Abdelrahman Mgr.
Balmagambetov, Daulet
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Syntheses and structure-activity relationships of novel P2X3 receptor antagonists [PDF]
, 2018 P2X3 receptors are ligand-gated ion channels activated by extracellular adenosine-5’-triphosphate (ATP). Activation of the P2X3 receptors has been linked to several pathophysiological conditions including inflammation and pain.
Rashed, Mahmoud Sayed Ahmed Mahmoud
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