Results 81 to 90 of about 1,333,073 (194)

Acute pulpitis promotes purinergic signaling to induce pain in rats via P38MAPK/NF-κB signaling pathway

open access: yesMolecular Pain
Toothache is one of the most common types of pain, but the mechanisms underlying pulpitis-induced pain remain unknown. The ionotropic purinergic receptor family (P2X) is reported to mediate nociception in the nervous system.
Yangxi Chen   +5 more
doaj   +1 more source

Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors

open access: yesMolecular Pain, 2010
Background Leukotrienes (LTs) belong to the large family of lipid mediators implicated in various inflammatory conditions such as asthma and rheumatoid arthritis.
Okubo Masamichi   +5 more
doaj   +1 more source

Taste‐Active Peptides: Sensation Mechanisms and Structure–Taste Relationships

open access: yesSensory Neuroscience, Volume 2, Issue 3, September 2026.
Overview of taste‐active peptides, including taste bud cellular organization, peptide–receptor interactions and signaling pathways, structure–taste relationships, and integrated computational and experimental strategies for peptide discovery, mechanism elucidation, and flavor modulation.
Dengyi Pei   +4 more
wiley   +1 more source

Expression of neuropeptides – galanin and Reg2 - in subcategories of nociceptors after nerve injury [PDF]

open access: yes, 2010
PhDNeuropeptides show dynamic changes in expression after nerve injury, and have been implicated in chronic pain states. I sought to compare expression of two peptides which are upregulated after nerve injury, galanin and Reg2, and to determine the ...
Burrows, Karen Lynne
core   +3 more sources

Prostaglandin E2 potentiation of P2X3 receptor mediated currents in dorsal root ganglion neurons

open access: yesMolecular Pain, 2007
Prostaglandin E2 (PGE2) is a well-known inflammatory mediator that enhances the excitability of DRG neurons. Homomeric P2X3 and heteromeric P2X2/3 receptors are abundantly expressed in dorsal root ganglia (DRG) neurons and participate in the transmission
Huang Li-Yen   +2 more
doaj   +1 more source

A Role for Glycine Transporter‐2 Inhibitors in Regulating Accumbal Dopamine Levels and Voluntary Alcohol Intake in Rats

open access: yesAlcohol, Clinical and Experimental Research, Volume 50, Issue 9, September 2026.
Partial inhibition of glycine transporter‐2 (GlyT2) elevates basal dopamine levels in the nucleus accumbens and abolishes the alcohol deprivation effect in rats. The findings reveal a role for GlyT2‐expressing glycinergic neurons in regulating mesolimbic dopamine signaling and relapse‐like alcohol drinking, highlighting GlyT2 as a potential target for ...
Yasmin Olsson   +6 more
wiley   +1 more source

Purinergic Signaling in Swallowing Reflex Initiation: Mechanisms and Therapeutic Implications for Oropharyngeal Dysphagia—A Narrative Review

open access: yesCells
The swallowing reflex is a highly coordinated process that is essential for safe bolus transit and airway protection. Although its neurophysiological framework has been extensively studied, the molecular mechanisms underlying reflex initiation remain ...
Junrong Qi   +4 more
doaj   +1 more source

B-type natriuretic peptide-induced delayed modulation of TRPV1 and P2X3 receptors of mouse trigeminal sensory neurons.

open access: yesPLoS ONE, 2013
Important pain transducers of noxious stimuli are small- and medium-diameter sensory neurons that express transient receptor vanilloid-1 (TRPV1) channels and/or adenosine triphosphate (ATP)-gated P2X3 receptors whose activity is upregulated by endogenous
Sandra Vilotti   +3 more
doaj   +1 more source

The Locus Coeruleus–Norepinephrine System Mediates Empathy for Pain through Selective Up-Regulation of P2X3 Receptor in Dorsal Root Ganglia in Rats

open access: yesFrontiers in Neural Circuits, 2017
Empathy for pain (vicariously felt pain), an ability to feel, recognize, understand and share the painful emotions of others, has been gradually accepted to be a common identity in both humans and rodents, however, the underlying neural and molecular ...
Yun-Fei Lü   +13 more
doaj   +1 more source

Prostaglandin E2 potentiation of P2X3 receptor mediated currents in dorsal root ganglion neurons-1

open access: yes, 2011
Copyright information:Taken from "Prostaglandin E2 potentiation of P2X3 receptor mediated currents in dorsal root ganglion neurons"http://www.molecularpain.com/content/3/1/22Molecular Pain 2007;3():22-22.Published online 10 Aug 2007PMCID:PMC2063498.
Guang-Wen Li (81506)   +2 more
core   +1 more source

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