Results 101 to 110 of about 1,333,073 (194)

The P2X3 receptor antagonist filapixant in patients with refractory chronic cough: a randomized controlled trial. [PDF]

Respir Res, 2023
Friedrich C, Francke K, Birring SS, van den Berg JWK, Marsden PA, McGarvey L, Turner AM, Wielders P, Gashaw I, Klein S, Morice AH.   +10 more
europepmc   +1 more source

P2X3 receptor localizes into lipid rafts in neuronal cells

, 2004
P2X receptors are a family of seven (P2X(1-7)) cation channels gated by extracellular ATP, widely expressed in neurons and nonneuronal cells. Lipid rafts are cholesterol/sphingolipid-rich membrane domains, involved in many cellular processes, including ...
Bernardi G, Vacca F, Amadio S, BERNARDI, GIORGIO, Sancesario G, Volonté C., SANCESARIO, GIUSEPPE   +6 more
core   +1 more source

Corrigendum: Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are competitive antagonists of the human P2X3 receptor. [PDF]

Front Pharmacol, 2023
Grohs L, Cheng L, Cönen S, Haddad BG, Bülow A, Toklucu I, Ernst L, Körner J, Schmalzing G, Lampert A, Machtens JP, Hausmann R.   +11 more
europepmc   +1 more source

Diclofenac and other non-steroidal anti-inflammatory drugs (NSAIDs) are competitive antagonists of the human P2X3 receptor. [PDF]

Front Pharmacol, 2023
Grohs L, Cheng L, Cönen S, Haddad BG, Bülow A, Toklucu I, Ernst L, Körner J, Schmalzing G, Lampert A, Machtens JP, Hausmann R.   +11 more
europepmc   +1 more source

The scaffold protein calcium/calmodulin-dependent serine protein kinase controls ATP release in sensory ganglia upon P2X3 receptor activation and is part of an ATP keeper complex.

, 2016
P2X3 receptors, gated by extracellular ATP, are expressed by sensory neurons and are involved in peripheral nociception and pain sensitization. The ability of P2X3 receptors to transduce extracellular stimuli into neuronal signals critically depends on ...
Fabbretti, Elsa, Tanja Bele, Bele, Tanja, Elsa Fabbretti   +3 more
core   +1 more source

P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization.

PLoS ONE, 2015
ObjectivesExperiments using P2X3 knock-out mice or more general P2X receptor antagonists suggest that P2X3 receptors contribute to visceral hypersensitivity.
Annemie Deiteren, Laura van der Linden, Anouk de Wit, Hannah Ceuleers, Roeland Buckinx, Jean-Pierre Timmermans, Tom G Moreels, Paul A Pelckmans, Joris G De Man, Benedicte Y De Winter   +9 more
doaj   +1 more source

Clinical Formulation Bridging of Gefapixant, a P2X3-Receptor Antagonist, for the Treatment of Chronic Cough. [PDF]

Clin Pharmacol Drug Dev, 2022
Gupta P, Hussain A, Ford AP, Smith S, Nussbaum JC, Stoch A, Iwamoto M.   +6 more
europepmc   +1 more source

Chronic administration of the selective P2X3, P2X2/3 receptor antagonist, A-317491, transiently attenuates cancer-induced bone pain in mice

, 2012
The purinergic P2X3 and P2X2/3 receptors are in the peripheral nervous system almost exclusively confined to afferent sensory neurons, where they are found both at peripheral and central synapses.
Heegaard, Anne-Marie, Hansen, RR, Ding, Ming; id_orcid, Hansen, Rikke Rie, Baldvinsson, SB, Jarvis, MF, Nasser, Arafat, Bahl, JM, Ding, Ming, Nasser, A, Bahl, Justyna M. C., Ohlsson, PH, Heegaard , AM, Baldvinsson, Signe B., Falk, S, Falk, Sarah, Jarvis, Michael F, Ohlsson, Pernille H   +17 more
core   +1 more source

Amplified P2X3 pathway activity in muscle afferent dorsal root ganglion neurons and exercise pressor reflex regulation in hindlimb ischaemia–reperfusion

Experimental Physiology
Hindlimb ischaemia–reperfusion (IR) is among the most prominent pathophysiological conditions observed in peripheral artery disease (PAD). An exaggerated arterial blood pressure (BP) response during exercise is associated with an elevated risk of ...
Lu Qin, Qin Li, Jianhua Li
doaj   +1 more source

The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia

Purinergic Signalling
Endometriosis is a chronic gynecological condition characterized by endometrial tissue outside the uterine cavity. Recent research has focused on the relationship between the purinergic system and endometriosis. As a purinergic system component, extracellular adenosine triphosphate (ATP) has been involved as a crucial mediator of chronic pain ...
Kailane Paula Pretto, Letícia de Souza Matias, Bruna Dias de Oliveira, Adinei Abadio Soares, Camila Ferreira Puntel, Yghor Augusto da Rocha Ricardo, Yenidis Teilor Scheibel, Débora Tavares de Resende e Silva   +7 more
openaire   +2 more sources