Results 111 to 120 of about 1,333,073 (194)

Selectivity of the P2X3 receptor antagonist Eliapixant, and its potential use in the treatment of endometriosis. [PDF]

Purinergic Signal, 2022
Fletcher MC.
europepmc   +1 more source

Topical ATP Application in the Peripheral Swallowing-Related Regions Facilitates Triggering of the Swallowing Reflex Involving P2X3 Receptors

Function
The swallowing reflex is a critical component of the digestive process, triggered when food or liquids pass from the oral cavity to the oesophagus. Although adenosine triphosphate (ATP) is involved in various physiological processes, its potential to ...
Mohammad Zakir Hossain, Hiroshi Ando, Rita Rani Roy, Junichi Kitagawa   +3 more
doaj   +1 more source

The distribution of P2X3 purine receptor subunits in the guinea pig enteric nervous system

, 2002
Adenosine 5′-triphosphate (ATP) excites 70-90% of enteric neurons through P2X type purine receptors, and is likely to be an enteric neurotransmitter. Recent studies indicate that the P2X2 subunit is expressed by specific subgroups of enteric neurons, and
Poole D. P., Robbins H. L., Furness J. B., Chiocchetti R., Castelucci P.   +4 more
core   +1 more source

Molecular physiology of sensory P2X3 ATP receptor channels

, 2012
Purinergic transmission mediated by extracellular release of ATP has been shown to be involved in numerous physiological processes, ranging from bladder function to taste and hearing.
Mo, Gary
core  

Ambient TNFα may not contribute to basal upregulation of KI P2X3 receptor function.

, 2013
A, Representative traces of currents induced by application of α,β-meATP (10 µM, 2 s) to WT or R192Q KI neurons in control conditions or after overnight application of anti-TNFα antibody.
Michel D. Ferrari (103728), Andrea Nistri (103736), Arn M. J. M. van den Maagdenberg (103732), Swathi K. Hullugundi (399941)   +3 more
core   +1 more source

First-in-human study of eliapixant (BAY 1817080), a highly selective P2X3 receptor antagonist: Tolerability, safety and pharmacokinetics. [PDF]

Br J Clin Pharmacol, 2022
Klein S, Gashaw I, Baumann S, Chang X, Hummel T, Thuß U, Friedrich C.   +6 more
europepmc   +1 more source

Analgesic effect of electroacupuncture on bone cancer pain in rat model: the role of peripheral P2X3 receptor. [PDF]

Purinergic Signal, 2023
Tian SX, Xu T, Shi RY, Cai YQ, Wu MH, Zhen SJ, Wang W, Zhou Y, Du JY, Fang JF, Shao XM, Liu BY, Jiang YL, He XF, Fang JQ, Liang Y.   +15 more
europepmc   +1 more source

Calcium permeability and block at homomeric and heteromeric P2X2 and P2X3 receptors, and P2X receptors in rat nodose neurones

, 1998
1. Whole-cell recordings were made from HEK 293 (human embryonic kidney) cells stably transfected with cDNAs encoding P2X2, P2X3 or both receptors (P2X(2/3)) and from cultured rat nodose neurones. Nodose neurones all showed immunoreactivity for both P2X2
Virginio, Caterina, North, R. A., Surprenant, Annmarie   +2 more
core   +1 more source

Safety, Pharmacodynamics, and Pharmacokinetics of P2X3 Receptor Antagonist Eliapixant (BAY 1817080) in Healthy Subjects: Double-Blind Randomized Study. [PDF]

Clin Pharmacokinet, 2022
Friedrich C, Francke K, Gashaw I, Scheerans C, Klein S, Fels L, Smith JA, Hummel T, Morice A.   +8 more
europepmc   +1 more source

A tale of two ATPs: biased activation of the P2X3 receptor

Purinergic Signalling
In a recent publication in Proceedings of the National Academy of Science, Wang et al. explore the structural and physiological outcomes of P2X3 receptor (P2X3R) activation by MgATP2- and ATP4-, two endogenous forms of ATP. The authors find that the P2X3R, which mediates pain and taste perception as well as cough responses, exhibits distinct ...
openaire   +2 more sources