Results 71 to 80 of about 28,978 (256)

Clinical Factors Associated With Pneumocystis Pneumonia Despite Its Primary Prophylaxis: When to Stop Prophylaxis?

Arthritis &Rheumatology, EarlyView.
Objective Although previous studies show that primary prophylaxis against Pneumocystis jirovecii pneumonia (PJP) is effective in patients with rheumatic diseases receiving immunosuppressive treatment, there is limited evidence regarding the optimal timing for prophylaxis withdrawal.
Ju Yeon Kim, Se Rim Choi, Jin Kyun Park, Eun Young Lee, Eun Bong Lee, Jun Won Park   +5 more
wiley   +1 more source

Lupus Panniculitis: a rare bilateral and symmetrical manifestation of cutaneous Lupus Erythematosus in an adolescent girl

Dermatology Reports, 2022
Lupus panniculitis is included in the chronic cutaneous lupus erythematosus group. A 18-year-old female patient came with the complaint of lumps on her face.
Agnes Rosarina Prita Sari, Paranita Ferronika, Hardyanto Soebono, Flandiana Yogianti   +3 more
doaj   +1 more source

Would You Recognize Lupus? [PDF]

, 2018
Systemic Lupus Erythematosus, or SLE, is a chronic autoimmune disease which significantly affects various organs of the body and the oral cavity. According to various studies, SLE can cause an increased risk of periodontitis, fungal infections, and ...
Brown, Barbara, Simms, Maegan, Smith, Sydney C   +2 more
core   +1 more source

Population pharmacokinetic modelling of prednisolone in systemic lupus erythematosus patients: Analysis of exposure and disease activity

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Prednisone is a widely used glucocorticoid in the treatment of lupus, although its dosing is often determined empirically. Prednisolone, the active metabolite of prednisone, is found in its free form in the serum. The goal of this study was to develop a population pharmacokinetic model in patients with systemic lupus erythematosus (SLE ...
Naïm Bouazza, Michaela Semeraro, Gabrielle Lui, Léo Froelicher‐Bournaud, Laure Choupeaux, Jean‐Marc Treluyer, Sihem Benaboud, Joelle Terzic, Eric Hachulla, Philippe Remy, Jérôme Harambat, Alexandre Karras, Caroline Rousset‐Rouviere, Anne Jolivot, Zahir Amoura, Eric Daugas, Aurélie Hummel, Rémi Salomon, Jean‐Christophe Lega, Stéphane Decramer, Alexandre Belot, Delphine Gobert, Nathalie Costedoat‐Chalumeau, Stanislas Faguer, Isabelle Melki, Noémie Jourde‐Chiche, Brigitte Bader‐Meunier   +26 more
wiley   +1 more source

A Case of Tumid Lupus Erythematosus Successfully Treated with Topical Tacrolimus and Hydrocortisone 17-Butyrate

Gazi Medical Journal
Tumid lupus erythematosus is an uncommon subtype of chronic cutaneous lupus erythematosus. Hereby, we report a 36-year-old male patient with tumid lupus erythematosus who presented with erythematous papules and plaques on the face and neck who showed ...
Funda Tamer, İrem Özdemir, Betül Öğüt, Özlem Erdem   +3 more
doaj   +1 more source

The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation.

PLoS ONE, 2022
Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of lupus development.
Tania Rahim, Madison A Levinson, Kelly E W Carufe, Matthew Burak, Rithy Meas, Stephen Maher, Alfred L M Bothwell, Naomi Gades, Joann B Sweasy   +8 more
doaj   +1 more source

Autologous fat grafting for treating lipoatrophy secondary to lupus erythematosus panniculitis [PDF]

, 2016
Lupus erythematosus panniculitis (LEP) is an uncommon variant of LE and accounts for only 1–3% of cutaneous LE cases. LEP lesions often heal with cutaneous scarring and lipoatrophy resulting in disfigurement.
Arai, Crowson, Strober, Braunstein, Eastham, Gir, Valdatta, Gleeson, Martens, Marzano, Costner, Hansen, Carvalho Costa, Vera-Lastra, Lemperle, Hoerl, Teimourian, Christman, Coleman, Wang   +19 more
core   +1 more source

Pharmacokinetics, Safety, and Tolerability of Single‐Dose Dazukibart in Healthy Adults in China and Japan: Results From 2 Randomized, Double‐Blind, Phase 1 Studies

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Dazukibart is a humanized monoclonal antibody selectively targeting interferon‐β. The pharmacokinetics (PK), safety, tolerability, and immunogenicity of dazukibart were evaluated in 2 double‐blind, randomized, placebo‐controlled, single‐dose, Phase 1 studies in healthy adults in China (Study 1: N = 18; dazukibart 900 mg = 15; placebo = 3) and ...
Naihan Chen, Yamato Sano, Xiaohong Wang, Shuiyi Hu, Junichi Tabira, Xin Luo, Hiroki Yoshimatsu, John Prybylski, Myron Chu, Haiyan Li, Kenji Takazawa   +10 more
wiley   +1 more source

Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus [PDF]

, 2016
BACKGROUND: Current evidence indicates that estrogens, in particular 17β-estradiol (E2), play a crucial role in the gender bias of autoimmune diseases although the underlying molecular mechanisms have not yet been fully elucidated.
ALESSANDRI, cristiano, BARBATI, CRISTIANA, Ciarlo, Laura, COLASANTI, TANIA, CONTI, FABRIZIO, Maselli, Angela, Ortona, Elena, Patrizio, Mario, Pierdominici, Marina, SPINELLI, FRANCESCA ROMANA, VALESINI, Guido, VOMERO, MARTA   +11 more
core   +1 more source

Associação entre lúpus eritematoso e tabagismo Association between lupus erythematosus and smoking

Anais Brasileiros de Dermatologia, 2008
FUNDAMENTOS: O lúpus eritematoso é doença crônica, auto-imune, que reúne manifestações exclusivamente cutâneas ou multissistêmicas, caracterizada pela produção de auto-anticorpos contra vários constituintes celulares.
Júnia Maria Fernandes Araújo, Ana Rosa Magaldi Ribeiro de Oliveira, Sâmya Diégues Cedrim, Olímpia Castelo Tristão, Aloísio Gamonal   +4 more
doaj   +1 more source