Results 71 to 80 of about 32,878 (253)

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Characteristics of Cutaneous Lupus Erythematosus Patients in Dermatology and Venereology Outpatient Clinic

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology)
Background: Cutaneous lupus erythematosus (CLE) is a specific skin manifestation of lupus erythematosus. This condition can be accompanied by systemic involvement that affect patient therapy and prognosis. The characteristics of CLE patients in Indonesia
Nyoman Suryawati, I Gusti Ayu Agung Praharsini, I Gusti Ayu Agung Elis Indara, I Gusti Nyoman Darmaputra   +3 more
doaj   +1 more source

Genome-wide transcriptional profiling data from chronic cutaneous lupus erythematosus (CCLE) peripheral blood

Data in Brief, 2015
The disease Lupus erythematosus (LE), exhibits a variety of clinical manifestations with potentially wide-ranging multi-organ damage to joints, tendons, kidney, lung, heart, blood vessels, central nervous system and skin [1,2] Systemic changes are likely
R. Dey-Rao, A.A. Sinha
doaj   +1 more source

Hematopoietic stem cell transplantation in autoimmune disorders: from immune-regulatory processes to clinical implications [PDF]

, 2018
K
Nakken, Britt, Papp, Gábor, Szodoray, Péter, Zeher, Margit   +3 more
core   +1 more source

A cooperative release of mitochondrial DNA from platelets and neutrophils drives an interferon signature in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Recognizing ophiasis pattern in discoid lupus: a rare diagnostic challenge

Dermatology Reports
Lupus erythematosus is an autoimmune condition that can present in both cutaneous and systemic forms, with discoid lupus erythematosus (DLE) being the most prevalent type of chronic cutaneous lupus.
Lamia Alakrash, Sara Alrabiah, Sawsan Alharthi   +2 more
doaj   +1 more source

Persistent lip enlargement: An unusual presentation of lupus erythematosus

International Journal of Women's Dermatology, 2017
Macrocheilia is a challenging problem with a variety of underlying causes that are both local and systemic, and granulomatous causes underlie the majority of cases.
A. Nikoo, M. Daneshpazhooh, S. Fahim, A. Ghanadan, H. Mahmoudi, L. Izadi Firoozabadi   +5 more
doaj   +1 more source

Efficacy and Safety of Subcutaneous Anifrolumab in Systemic Lupus Erythematosus: the Randomized, Phase 3, TULIP‐SC Study

Arthritis &Rheumatology, Accepted Article.
Objective The multinational, phase 3, double‐blind, placebo‐controlled TULIP‐SC trial evaluated the efficacy and safety of subcutaneous anifrolumab in adults who have moderate‐to‐severe SLE activity, despite receiving standard therapy. Methods Adults with SLE received subcutaneous anifrolumab 120 mg or placebo once weekly for 52 weeks (1:1 ...
Susan Manzi, Ian N. Bruce, Eric F. Morand, Richard Furie, Yoshiya Tanaka, Kenneth C. Kalunian, Anca Askanase, Patricia Puzio, Emon Khan, Jenny Wissmar, Michael Song, Catharina Lindholm, The TULIP‐SC investigators   +12 more
wiley   +1 more source

Discoid lupus erythematosus: A case report with review of the literature

Journal of Indian Academy of Oral Medicine and Radiology, 2009
Discoid lupus erythematosus (DLE) is the most common form of chronic cutaneous lupus erythematosus. Classic DLE lesions begin as red-purple macules, papules or small plaques and rapidly develop a hyperkeratotic surface.
C K Sreejan, R Gopakumar, Subhas Babu, R K Roopashri   +3 more
doaj   +1 more source

The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation.

PLoS ONE, 2022
Systemic lupus erythematosus is a chronic disease characterized by autoantibodies, renal and cutaneous disease, and immune complex formation. Emerging evidence suggests that aberrant DNA repair is an underlying mechanism of lupus development.
Tania Rahim, Madison A Levinson, Kelly E W Carufe, Matthew Burak, Rithy Meas, Stephen Maher, Alfred L M Bothwell, Naomi Gades, Joann B Sweasy   +8 more
doaj   +1 more source