Results 71 to 80 of about 4,214,463 (259)

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

COSS Network submission to Inquiry into chronic disease prevention and management in primary health care [PDF]

open access: yes
Chronic disease causes nine out of ten Australian deaths, according to this report. Chronic disease in Australia Chronic diseases in Australia are significant contributors to illness, disability and premature death.
Emma King
core  

2013 Dillon County Obesity Fact Sheet [PDF]

open access: yes, 2013
This fact sheet provides information on nutrition, physical activity, and obesity for Dillon ...
Department of Health and Environmental Control, Division of Chronic Disease Epidemiology
core  

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

2013 Union County Obesity Fact Sheet [PDF]

open access: yes, 2013
This fact sheet provides information on nutrition, physical activity, and obesity for Union ...
Department of Health and Environmental Control, Division of Chronic Disease Epidemiology
core   +1 more source

CHRONIC DISEASES OF THE STOMACH [PDF]

open access: yesSouthern Medical Journal, 1912
n ...
openaire   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

2013 Lee County Obesity Fact Sheet [PDF]

open access: yes, 2013
This fact sheet provides information on nutrition, physical activity, and obesity for Lee ...
Department of Health and Environmental Control, Division of Chronic Disease Epidemiology
core  

The Burden of Chronic Disease

open access: yesMayo Clinic Proceedings: Innovations, Quality & Outcomes
Chronic diseases like diabetes, heart disease, stroke, and cancer have been and continue to be some of the major causes of worldwide morbidity and mortality. A transition between infectious and noncommunicable diseases occurred in the early 1900s as a result of improved public health and has persisted ever since.
openaire   +3 more sources

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