Results 91 to 100 of about 37,007 (288)

Upadacitinib for difficult‐to‐treat paediatric Crohn's disease

JPGN Reports, EarlyView.
Abstract Paediatric‐onset inflammatory bowel disease (IBD) has an enormous impact on healthcare systems as it translates to a lifetime of healthcare. Since the approval of anti‐tumour necrosis factor‐alpha agents, it has become evident that in the long journey of paediatric IBD, there is an absolute need for more treatment options.
N. Nedelkopoulou, S. Sharma, M. Khalid, C. Hinchliffe   +3 more
wiley   +1 more source

A histopathologic evaluation of gross lesions excised from commercially important North Altantic marine fishes [PDF]

, 1986
Histopathologic studies of lesions found in commercially important North Atlantic marine fishes are uncommon. As part of a comprehensive Northeast Fisheries Center program ("Ocean Pulse") to evaluate environmental and resource health on the U.S ...
Despres-Patanjo, Linda, Murchelano, Robert A., Ziskowski, John   +2 more
core  

Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]

, 2018
Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S., Beattie, Lynette, Hoehme, Stefan, Kaye, Paul M., Moore, John W. J., Moyo, Daniel, Sampson, Adam T., Sawtell, Amy, Timmis, Jon   +8 more
core   +4 more sources

Genital Crohn's disease in pediatrics and genetic associations

JPGN Reports, EarlyView.
Abstract Genital edema is a rare presentation of Crohn's disease (CD), also known as metastatic CD (MCD). This may precede, co‐occur with, or follow gastrointestinal symptoms and present a diagnostic challenge. We aimed to characterize the features, clinical courses, pathogenesis, and outcomes of patients with MCD to increase understanding and promote ...
Erica Chang, Caroline Chinchilla Putzeys, Edward Hoffenberg, Ashish Patel, Elizabeth Hilow, Brad Pasternak   +5 more
wiley   +1 more source

Disseminated Aspergillosis as the Herald Manifestation of Chronic Granulomatous Disease in an Adult Patient

Iranian Journal of Allergy, Asthma and Immunology, 2014
Chronic granulomatous disease is an inherited defect in intracellular killing of ingested microorganisms characterized by recurrent life threatening bacterial and fungal infections including invasive aspergillosis in early childhood.
Ilad Alavi Darazam, Hossein Akhavan Zanjani, Davood Sanaee, Payam Tabarsi, Mostafa Alavi Moghaddam, Davood Mansouri   +5 more
doaj  

Granulomatous Mastitis Concurrence with Breast Cancer

European Journal of Breast Health, 2018
Idiopathic Granulomatous Mastitis (IGM) is a rare, chronic, non-malignant and non-life-threatening breast disease. IGM may mimic carcinoma of the breast. This case report is about concurrence of chronic granulomatous mastitis with breast cancer.
Hasan Çalış, Asuman Kilitçi
doaj   +1 more source

Idiopathic granulomatous mastitis with erythema nodosum and polyarthritis

Reumatismo, 2016
A 25 year-old woman presented with a painful mass in the left breast, polyarthritis and erythema nodosum. Fine needle aspiration cytology led to a diagnosis of granulomatous mastitis.
J. Alungal, M.C. Abdulla, R. Narayan
doaj   +1 more source

A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity [PDF]

, 2007
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a heritability of 60%. Genetic contributions to RA are made by multiple genes, but only a few gene associations have yet been confirmed.
Alfredsson, L, Burkhardt, H, Holmdahl, Rikard,, Kallberg, H, Klareskog, L, Lindqvist, Anna-Karin,, Lund University., Olsson, Lina,, Padyukov, L   +8 more
core   +2 more sources

Eosinophilic mesenteric vasculitis presenting as inflammatory bowel disease

JPGN Reports, EarlyView.
Abstract Inflammatory bowel disease (IBD), including Crohn's Disease (CD) and ulcerative colitis, is a chronic inflammatory condition affecting the gastrointestinal tract. Treatment for IBD depends on disease severity and can include medical and surgical management.
Razan Alkhouri, Craig Wong, Allyson Richards, David Martin, Joshua Hanson, Rasha Elmaoued, Rajmohan Dharmaraj, Ioannis Kalampokis   +7 more
wiley   +1 more source

Papulopustular Dermatitis in X-Linked Chronic Granulomatous Disease

Frontiers in Pediatrics, 2019
Here we describe two term male infants diagnosed with X-linked CGD who present, in addition to frequent infection, with a unique papulopustular skin rash. CGD is caused by a number of genetic defects that impair phagocyte function.
Puja Sood Rajani, Maria A. Slack
doaj   +1 more source