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Chronic Granulomatous Disease of Childhood
Advances in Pediatrics, 1969Abstract Chronic granulomatous disease in children is a disease of recurrent sepsis in children which results from a deficiency of a white cell DPNH oxidase. The fatality of the disease has previously been emphasized. However, a spectrum of disease exists with long-term survival possible.
A I, Philippart +2 more
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Annual Review of Medicine, 1992
Chronic granulomatous disease (CGD) encompasses a group of rare inherited disorders characterized by defects in a phagocyte-specific NADPH-oxidase complex that forms the superoxide radical during the respiratory burst. In this chapter, the protein components and cellular biochemistry of the oxidase are reviewed in light of recent genetic and ...
M C, Dinauer, S H, Orkin
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Chronic granulomatous disease (CGD) encompasses a group of rare inherited disorders characterized by defects in a phagocyte-specific NADPH-oxidase complex that forms the superoxide radical during the respiratory burst. In this chapter, the protein components and cellular biochemistry of the oxidase are reviewed in light of recent genetic and ...
M C, Dinauer, S H, Orkin
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Pediatric Radiology, 2010
Chronic granulomatous disease (CGD) is a rare congenital immunodeficiency characterized by recurrent bacterial and fungal infections as well as granuloma formation. The manifestations of this disease can involve single or multiple organ systems. The lungs are the most commonly affected organ; however, lymphatic, hepatic, skeletal, gastrointestinal ...
Alexander J, Towbin, Ian, Chaves
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Chronic granulomatous disease (CGD) is a rare congenital immunodeficiency characterized by recurrent bacterial and fungal infections as well as granuloma formation. The manifestations of this disease can involve single or multiple organ systems. The lungs are the most commonly affected organ; however, lymphatic, hepatic, skeletal, gastrointestinal ...
Alexander J, Towbin, Ian, Chaves
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Internal and Emergency Medicine, 2011
Chronic granulomatous disease (CGD) is a rare primary immunodeficiency due to an abnormal function of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase; NADPH oxidase is a key enzyme for the cellular "respiratory burst", the cellular process that converts molecular oxygen to the oxygen free-radical superoxide.
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Chronic granulomatous disease (CGD) is a rare primary immunodeficiency due to an abnormal function of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase; NADPH oxidase is a key enzyme for the cellular "respiratory burst", the cellular process that converts molecular oxygen to the oxygen free-radical superoxide.
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Chronic Granulomatous Disease in Adults
Lancet, The, 1996Chronic granulomatous disease (CGD), an inherited disorder of granulocyte function caused by failure of intracellular superoxide production, normally presents in the first years of life with severe recurrent bacterial and fungal infections.From the files of two children's hospitals we identified 11 CGD patients who were remarkable for an unusually late
Verena Jendrossek, M Gahr
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Postencephalitic Chronic Granulomatous Disease
Pediatric Neurology, 2006This report details the evolution of a case of herpes simplex encephalitis to chronic granuloma in a 13-year old female who, at the age of 8, suffered herpes simplex virus type 1 encephalitis. Eight months later, she developed an intracranial hypertension syndrome with the onset of a new lesion in the necrosed zone of her right temporal lobe, with no ...
J M Prats, Viñas +4 more
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Sarcoidosis in Chronic Granulomatous Disease
Pediatrics, 2006In addition to increased susceptibility to infections in patients with chronic granulomatous disease (CGD), a higher incidence of sterile inflammatory disorders in these patients has been noted. However, sarcoidosis has not been reported previously in CGD.
Suk See, De Ravin +10 more
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The management of chronic granulomatous disease
European Journal of Pediatrics, 1993Chronic granulomatous disease (CGD) is a primary immunodeficiency disease which results from absence of the NADPH oxidase in the professional phagocytic cells neutrophils, monocytes, macrophages and eosinophils. Deficiency of this oxidase renders the patient liable to infection by bacteria and fungi, and, as the name of the disease suggests, to chronic
A, Fischer +3 more
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Topics in Chronic Granulomatous Disease
Pediatrics, 1991To the Editor.— Such phagocytic cells as neutrophils and macrophages are crucial elements in the host defense against bacterial [See table in the PDF file] and fungal infections. Microbicidal activity depends to a large extent on NADPH oxidase system, which can be activated by stimuli (bacteria, fungi) and ...
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AMANTADINE IN CHRONIC GRANULOMATOUS DISEASE
Pediatric Hematology and Oncology, 2005Chronic granulomatous disease (CGD) is a rare genetically determined immunodeficiency. Neutrophils from CGD patients show a defective killing of phagocytosed fungi and bacteria, due not only to an impairment in oxidative burst, but also to absence of normal pH value within phagocytic vacuole following phagocytosis.
GRANZOTTO M +7 more
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