Results 71 to 80 of about 54,440 (295)

Extrapolation of lung pharmacokinetics of bedaquiline across species using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Aims Bedaquiline (BDQ) is a first‐in‐class diarylquinoline (DARQ) and a potent anti‐tuberculosis drug, vital in combating multi‐drug resistant tuberculosis (TB). Understanding its lung pharmacokinetics (PK) across species is crucial for effective clinical translation.
Evangelos Karakitsios, Oscar Della Pasqua, Aristides Dokoumetzidis   +2 more
wiley   +1 more source

The biochemical basis of nitroblue tetrazolium reduction in normal human and chronic granulomatous disease polymorphonuclear leukocytes [PDF]

, 1976
RL Baehner, LA Boxer, J Davis
openalex   +3 more sources

Perigraftitis treatment and histology: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background Currently, the two diagnoses of inflammatory peri‐implant diseases are peri‐implant mucositis and peri‐implantitis. The etiology of peri‐implant mucositis and peri‐implantitis is bacterial colonization of the implant. Thus, removal of the implant should eliminate the infection and allow the inflammation to resolve. However, at least
Jonathan H. Do, Charles M. Cobb, John T. Shen   +2 more
wiley   +1 more source

Think highly of immunoglobulin G4‐related chronic rhinosinusitis as a clinical entity in immunoglobulin G4‐related disease

Eye &ENT Research, EarlyView.
Abstract IgG4‐related chronic rhinosinusitis (IgG4‐related CRS) is gaining recognition among various specialized physicians. As a systemic disease involving multiple organs, IgG4‐related CRS is still not widely recognized as an independent clinical entity. Given the complexity of diagnosing autoimmune‐related multisystem diseases, early recognition and
Lianqi Wan, Luo Zhang, Yingshi Piao, Yuan Zhang   +3 more
wiley   +1 more source

Schistosoma mansoni in mice: modulation of granulomatous response after reinfection and chemotherapeutic treatment

Revista da Sociedade Brasileira de Medicina Tropical, 1994
Mice previously infected with Schistosoma mansoni, and cured by specific treatment (400mg/kg oxamniquine, p. o.) in the chronic phase of the disease, were reinfected 20 days after treatment to assess their capacityfor modulation ofthe granulomatous ...
Paulo Marcos Z. Coelho, Pedro Raso, Rômulo Teixeira de Mello, Nivaldo H. Toppa   +3 more
doaj   +1 more source

Effects of empagliflozin on uric acid levels during acute heart failure recompensation: A sub‐analysis of the EMPAG‐HF trial (Effects of Empagliflozin on Diuresis and Renal Function in Patients with Acute Decompensated Heart Failure)

European Journal of Heart Failure, EarlyView.
Effects of empagliflozin on uric acid levels during acute heart failure recompensation. Abstract Background Sodium–glucose cotransporter 2 inhibitors improve prognosis in chronic heart failure as part of currently recommended therapeutic strategies.
Jurgen Bogoviku, Tien Dung Nguyen, Julian Georg Westphal, Franz Haertel, Pawel Aftanski, Sven Möbius‐Winkler, Martin Busch, P. Christian Schulze   +7 more
wiley   +1 more source

Granulomatous Mastitis Concurrence with Breast Cancer

European Journal of Breast Health, 2018
Idiopathic Granulomatous Mastitis (IGM) is a rare, chronic, non-malignant and non-life-threatening breast disease. IGM may mimic carcinoma of the breast. This case report is about concurrence of chronic granulomatous mastitis with breast cancer.
Hasan Çalış, Asuman Kilitçi
doaj   +1 more source

Rasamsonia sp: An emerging infection amongst chronic granulomatous disease patients. A case of disseminated infection by a putatively novel Rasamsonia argillacea species complex involving the heart

Medical Mycology Case Reports, 2019
Chronic granulomatous disease (CGD) is a heterogeneous condition due to defects in NADPH oxidase characterized by granuloma formation and increased susceptibility to invasive infections, in particular moulds.
Ahmed Babiker, Nupur Gupta, Connie F.C. Gibas, Nathan P. Wiederhold, Carmita Sanders, James Mele, Hongxin Fan, Alina Iovleva, Ghady Haidar, Carolyn Fernandes   +9 more
doaj   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Papulopustular Dermatitis in X-Linked Chronic Granulomatous Disease

Frontiers in Pediatrics, 2019
Here we describe two term male infants diagnosed with X-linked CGD who present, in addition to frequent infection, with a unique papulopustular skin rash. CGD is caused by a number of genetic defects that impair phagocyte function.
Puja Sood Rajani, Maria A. Slack
doaj   +1 more source