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Understanding chronic heart failure [PDF]

Archives of Disease in Childhood, 2007
The key principles of chronic heart failure and the development of clinical management strategies are described. The physiological changes in chronic heart failure and the clinical management of children with heart failure are considered, but the treatment of heart failure related to congenital heart disease or the intensive care management of heart ...
Matthew, Fenton, Michael, Burch
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Atrial Tissue Pro‐Fibrotic M2 Macrophage Marker CD163+, Gene Expression of Procollagen and B‐Type Natriuretic Peptide

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Atrial tissue fibrosis is linked to inflammatory cells, yet is incompletely understood. A growing body of literature associates peripheral blood levels of the antifibrotic hormone BNP (B‐type natriuretic peptide) with atrial fibrillation (AF).
Chris J. Watson, Nadezhda Glezeva, Stephen Horgan, Joe Gallagher, Dermot Phelan, Ken McDonald, Michael Tolan, John Baugh, Patrick Collier, Mark Ledwidge   +9 more
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Pipersentan: A De Novo Synthetic Endothelin Receptor Antagonist that Inhibits Monocrotaline- and Hypoxia-Induced Pulmonary Hypertension

Frontiers in Pharmacology, 2022
Background: Although major advances have been made in the pathogenesis and management of pulmonary arterial hypertension (PAH), the endothelin system is still considered to play a vital role in the pathology of PAH due to its vasoconstrictive action ...
Zeyu Zhang, Zeyu Zhang, Zeyu Zhang, Chunlei Liu, Chunlei Liu, Yongyi Bai, Xin Li, Xin Li, Xiaojian Gao, Xiaojian Gao, Xiaojian Gao, Chen Li, Chen Li, Ge Guo, Ge Guo, Si Chen, Mingzhuang Sun, Kang Liu, Yang Li, Kunlun He, Kunlun He   +20 more
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Independent and combined effects of hypertension and diabetes on clinical outcomes in patients with COVID‐19: A retrospective cohort study of Huoshen Mountain Hospital and Guanggu Fangcang Shelter Hospital

The Journal of Clinical Hypertension, 2021
It is widely recognized that hypertension is one of the major risk factor for disease severity and mortality in patients with coronavirus disease 2019 (COVID‐19). However, type 2 diabetes mellitus (T2DM) and hypertension are frequent comorbid conditions,
Yuhui Sun, Xizhou Guan, Lijing Jia, Ning Xing, Liuquan Cheng, Bo Liu, Sibing Zhang, Kunlun He   +7 more
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F2RL3 Methylation in the Peripheral Blood as a Potential Marker for the Detection of Coronary Heart Disease: A Case-Control Study

Frontiers in Genetics, 2022
Background and Aims: Previous work has shown the association between blood-based methylation of coagulation factor II receptor-like 3 gene (F2RL3) and cardiovascular mortality in Caucasians.
Xiaojing Zhao, Xiaojing Zhao, Liya Zhu, Qiming Yin, Zhenguo Xu, Zhenguo Xu, Qian Jia, Qian Jia, Rongxi Yang, Kunlun He, Kunlun He   +10 more
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A Multi-Task Neural Network Architecture for Renal Dysfunction Prediction in Heart Failure Patients With Electronic Health Records

IEEE Access, 2019
Renal dysfunction, which is associated with bad clinical outcomes, is one of the most common complications of heart failure (HF). Timely prediction of renal dysfunction can help medical staffs intervene early to avoid catastrophic consequences.
Binhua Wang, Yongyi Bai, Zhenjie Yao, Jiangong Li, Wei Dong, Yanhui Tu, Wanguo Xue, Yaping Tian, Yifei Wang, Kunlun He   +9 more
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Using artificial intelligence in the development of diagnostic models of coronary artery disease with imaging markers: A scoping review

Frontiers in Cardiovascular Medicine, 2022
BackgroundCoronary artery disease (CAD) is a progressive disease of the blood vessels supplying the heart, which leads to coronary artery stenosis or obstruction and is life-threatening.
Xiao Wang, Xiao Wang, Xiao Wang, Junfeng Wang, Wenjun Wang, Wenjun Wang, Wenjun Wang, Mingxiang Zhu, Mingxiang Zhu, Mingxiang Zhu, Hua Guo, Junyu Ding, Jin Sun, Jin Sun, Jin Sun, Di Zhu, Di Zhu, Di Zhu, Yongjie Duan, Yongjie Duan, Yongjie Duan, Xu Chen, Xu Chen, Xu Chen, Peifang Zhang, Zhenzhou Wu, Kunlun He, Kunlun He, Kunlun He   +28 more
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Construction of a Non-Mutually Exclusive Decision Tree for Medication Recommendation of Chronic Heart Failure

Frontiers in Pharmacology, 2022
Objective: Although guidelines have recommended standardized drug treatment for heart failure (HF), there are still many challenges in making the correct clinical decisions due to the complicated clinical situations of HF patients.
Yongyi Bai, Yongyi Bai, Haishen Yao, Xuehan Jiang, Suyan Bian, Suyan Bian, Jinghui Zhou, Xingzhi Sun, Gang Hu, Lan Sun, Guotong Xie, Kunlun He, Kunlun He   +12 more
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Inhibiting Receptor of Advanced Glycation End Products Attenuates Pressure Overload-Induced Cardiac Dysfunction by Preventing Excessive Autophagy

Frontiers in Physiology, 2018
The receptor for advanced glycation end products (RAGE) is involved in heart failure (HF) by mediating diverse pathologic processes, including the promotion of inflammation and autophagy.
Wenbin Gao, Wenbin Gao, Wenbin Gao, Zheng Zhou, Zheng Zhou, Zheng Zhou, Birong Liang, Birong Liang, Birong Liang, Yusheng Huang, Yusheng Huang, Yusheng Huang, Zhongqi Yang, Zhongqi Yang, Zhongqi Yang, Yang Chen, Yang Chen, Lu Zhang, Lu Zhang, Lu Zhang, Cui Yan, Cui Yan, Cui Yan, Jiajia Wang, Jiajia Wang, Jiajia Wang, Lu Lu, Lu Lu, Lu Lu, Zhaorui Wen, Zhaorui Wen, Shaoxiang Xian, Shaoxiang Xian, Shaoxiang Xian, Lingjun Wang, Lingjun Wang, Lingjun Wang   +36 more
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Novel Targets in a High-Altitude Pulmonary Hypertension Rat Model Based on RNA-seq and Proteomics

Frontiers in Medicine, 2021
High-altitude pulmonary hypertension (HAPH) is a complication arising from an inability to acclimatize to high altitude and is associated with high morbidity and mortality.
Xiang Xu, Hanlu Li, Qingxia Wei, Xin Li, Xin Li, Yanying Shen, Ge Guo, Yibing Chen, Kunlun He, Kunlun He, Chunlei Liu, Chunlei Liu   +11 more
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