Building a High-Throughput Yeast Two-Hybrid Assay to Screen for Novel Chronic Hepatitis B Drugs [PDF]
, 2023 Hepatitis B is a vaccine preventable liver disease caused by hepatitis B virus (HBV). Chronic hepatitis B currently affects about 296 million people around the world, killing 820,000 annually.
Glazer, Benjamin
core +1 more source
Signal Transduction and Targeted TherapyThis study aimed to develop a pan-genotypic and multifunctional small interfering RNA (siRNA) against hepatitis B virus (HBV) with an efficient delivery system for treating chronic hepatitis B (CHB), and explore combined RNA interference (RNAi) and ...
Wenjing Zai +10 more
doaj +1 more source
Non-invasive Assessment of Hepatic Venous Pressure Gradient (HVPG) Based on MR Flow Imaging and Computational Fluid Dynamics [PDF]
arXiv, 2021 Clinically significant portal hypertension (CSPH) is a severe complication of chronic liver disease associated with cirrhosis, which is diagnosed by the measurement of hepatic venous pressure gradient (HVPG). However, HVPG measurement is invasive and therefore difficult to be widely applied in clinical routines.
arxiv
CLINICAL RELEVANCE OF PRECORE MUTATIONS OF HEPATITIS B VIRUS IN CHRONIC LIVER DISEASE [PDF]
, 2014 Introduction: Hepatitis B is one of the most frequent etiological factors for chronic liver diseases worldwide. Recent studies have suggested the important role of the genetic diversity of the virus on natural course of hepatitis B. Hepatitis B e-antigen
Chaloska Ivanova Viktorija +4 more
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Hepatitis B Screening and Vaccination Practices in Asian American Primary Care
Gut and Liver, 2013 Background/AimsScreening for hepatitis B virus (HBV) is recommended in populations with anticipated prevalence ≥2%. This study surveyed HBV screening and vaccination practices of Asian American primary care providers (PCPs).Methods : Approximately 15,000
doaj +1 more source
Identifying downregulated hub genes and key pathways in HBV-related hepatocellular carcinoma using systems biology approach [PDF]
arXiv, 2023 Chronic Hepatitis B (CHB) is an independent risk factor for hepatocellular carcinoma (HCC) initiation without cirrhosis occurrence. Apart from the favorable effects of some antiviral drugs following tumor resection on the survival of HCC patients, the use of these agents is essential lifelong.
arxiv
VirusesHepatitis B is transmitted sexually, by blood contact, and vertically from mother to child. Chronic hepatitis B is often seen in immigrants from higher-prevalence countries and their Canadian-born children.
Sheila F. O’Brien +3 more
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Evolution of hepatitis B virus liver disease after hepatic replacement. Practical and theoretical considerations [PDF]
, 1990 The morphologic evolution of hepatitis B virus (HBV) liver disease in 45 hepatic allograft recipients who were HBV surface-antigen positive (HBs-Ag+) at the time of liver replacement and who survived for more than 60 days was studied by routine ...
Demetris, AJ +8 more
core +1 more source
Recent Insights into the Role of B Cells in Chronic Hepatitis B and C Infections
Pathogens, 2023 Chronic viral hepatitis infections, caused by the hepatitis B or C virus, are a major global health problem causing an estimated one million deaths each year.
Zgjim Osmani, Andre Boonstra
doaj +1 more source
Global analysis of a spatiotemporal cellular model for the transmission of hepatitis C virus with Hattaf-Yousfi functional response [PDF]
arXiv, 2021 In this paper, a mathematical analysis of the global dynamics of a partial differential equation viral infection cellular model is carried out. We study the dynamics of a hepatitis C virus (HCV) model, under therapy, that considers both absorption phenomenon and diffusion of virions, infected and uninfected cells in liver. Firstly, we prove boundedness
arxiv