Results 41 to 50 of about 1,924,182 (309)

Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy

mBio
The persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a key obstacle for HBV cure. This study aims to comprehensively assess the effect of interferon (IFN) and small-interfering RNA (siRNA) combination on the cccDNA ...
Kongying Hu, Wenjing Zai, Mingzhu Xu, Haiyu Wang, Xinluo Song, Chao Huang, Jiangxia Liu, Juan Chen, Qiang Deng, Zhenghong Yuan, Jieliang Chen   +10 more
doaj   +1 more source

Sustained exposure to systemic endotoxin triggers chemokine induction in the brain followed by a rapid influx of leukocytes

Journal of Neuroinflammation, 2020
Background Recent years have seen an explosion of research pertaining to biological psychiatry, yet despite subsequent advances in our understanding of neuroimmune communication pathways, how the brain senses and responds to peripheral inflammation ...
Carolyn A. Thomson, Alison McColl, Gerard J. Graham, Jonathan Cavanagh   +3 more
doaj   +1 more source

Differentiation and Protective Capacity of Virus-Specific CD8 [PDF]

, 2017
Noroviruses can establish chronic infections with active viral shedding in healthy humans but whether persistence is associated with adaptive immune dysfunction is unknown.
Bengsch, Bertram, Cosma, Gabriela L., Eisenlohr, Laurence C., Lau, Chi Wai, Manne, Sasikanth, Nice, Timothy J., Palko, Olesya, Pattekar, Ajinkya, Sun, Yuhang, Tacheva, Ralitza, Tomov, Vesselin T., Virgin, Herbert W., Wherry, E. John   +12 more
core   +1 more source

An immunocompromised dialysis patient with skin and bone lesions [PDF]

, 2010
Patients with chronic kidney failure have disturbances of immune function involving both innate and adaptive systems. These result in both immunodepression which increases susceptibility to infection and immunoactivation leading to a chronic inflammatory
Brown, Griffith, Jarzembowski, Katoch, Swenson, Uslan, Wallace, Wallace   +7 more
core   +2 more sources

Rituximab-Containing Treatment Regimens May Imply a Long-Term Risk for Difficult-To-Treat Chronic Hepatitis E [PDF]

, 2020
Hepatitis E virus (HEV) infection is an emerging disease in industrialized countries which is usually characterized by a self-limited course. However, there is an increased risk of HEV persistence in immunocompromised risk populations, comprising ...
Biedermann, Paula, Bock, Claus-Thomas, Choi, Mira, Hanitsch, Leif Gunnar, Hofmann, Jörg, Mueller, Tobias, Schulz, Marten, Tacke, Frank   +7 more
core   +1 more source

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2

Respiratory Research
Mycobacterium tuberculosis (M. tb) is an intracellular pathogen adept at evading the human immune system through a variety of mechanisms. During infection, M.
Lin Zhang, Fang Fang, Danrui Liu, Geman Xia, Tong Feng, Jingzhu Lv, Jinying Qi, Tengteng Li, Hui Liu, Tao Xu, Fengjiao Wu, Chuanwang Song, Wei Li, Xiaojing Wang, Xianyou Chang, Hongtao Wang, Ting Wang, Zhongqing Qian   +17 more
doaj   +1 more source

An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes

Emerging Microbes and Infections
Type I interferons (IFN-Is) have key roles in immune defense and treatments for various diseases, including chronic hepatitis B virus (HBV) infection.
Yumeng Li, Asha Ashuo, Menghan Hao, Yaming Li, Jianyu Ye, Jiangxia Liu, Ting Hua, Zhong Fang, Jianhua Li, Zhenghong Yuan, Jieliang Chen   +10 more
doaj   +1 more source

Intraoperative Collection of Ascitic Fluid With Intra‐ or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell‐free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.
Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami   +7 more
wiley   +1 more source

The insula represents a key neurobiological pain hub in psoriatic arthritis

Arthritis Research & Therapy
Background Pain remains a principal complaint for people with psoriatic arthritis (PsA), despite successful mitigation of inflammation. This situation alludes to the co-existence of distinct pain mechanisms.
Flavia Sunzini, Kristian Stefanov, Salim Al-Wasity, Chelsea Kaplan, Andrew Schrepf, Noah Waller, Steven Harte, Richard Harris, Daniel J. Clauw, John McLean, Stefan Siebert, Carl S. Goodyear, Gordon D. Waiter, Neil Basu   +13 more
doaj   +1 more source