Results 21 to 30 of about 1,319,691 (347)

The Podocyte in Diabetic Kidney Disease

The Scientific World Journal, 2009
Approaching epidemic levels, diabetic kidney disease (DKD) is now the leading cause of end-stage renal disease (ESRD). Microalbuminuria is an early clinical marker of DKD that results from damage to the glomerular filtration barrier at the level of the ...
Erin Stitt-Cavanagh, Laura MacLoed, Chris R.J. Kennedy   +2 more
doaj   +1 more source

The effect of the association between CETP variant type and alcohol consumption on cholesterol level differs according to the ALDH2 variant type

Scientific Reports, 2022
Alcohol consumption is associated with a high increased lipid profile and this association may depend on genetic risk factors. In this study, we aimed to assess the effects of genetic variation associated with alcohol consumption on lipid profiles using ...
Min-Gyu Yoo, Ji Ho Yun, Soo Kyung Koo, Hye-Ja Lee   +3 more
doaj   +1 more source

Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1 [PDF]

, 2018
Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis is ...
A Clayton, A Desmouliere, A Holmes, A Yabuki, AA Eddy, AA Eddy, AC Sanchez-Lara, BL Aken, C Grupp, C. P. D. Wheeler-Jones, CH Heldin, CL Marino, E Honda, E Van Obberghen-Schilling, F Strutz, F Strutz, F Syeda, GR Grotendorst, H. M. Syme, HP Rodemann, J Ivaska, J Lu, J. Elliott, J. S. Lawson, JL Mumaw, JS Lawson, K Sawashima, KG McCullagh, KJ Kelynack, LC Penning, M Prunotto, M Zeisberg, MA Venkatachalam, MJ Ryan, MK Phanish, ML Sequeira Lopez, P Boor, P Sysa, PC Bartlett, Q Chai, RA Ignotz, S Chakrabarti, S Meran, S Moll, S Neelisetty, SC Chen, SL Lin, SP DiBartola, SW Smith, T Akamatsu, TA Wynn, V Dugina, VS Lebleu, W Bloom, WA Border, X Pan, XM Meng, Y Hosokawa, Y Liu   +58 more
core   +2 more sources

Thiazides in advanced chronic kidney disease—time for a randomized controlled trial? [PDF]

, 2015
Purpose of review: Chronic kidney disease is common, associated with increased cardiovascular risk, and frequently complicated by hypertension, requiring multiple agents for control.
Agarwal, Rajiv, Sinha, Arjun D.
core   +1 more source

Blockage of the lysosome-dependent autophagic pathway contributes to complement membrane attack complex-induced podocyte injury in idiopathic membranous nephropathy

Scientific Reports, 2017
Dysregulation of autophagy-mediated podocyte homeostasis is proposed to play a role in idiopathic membranous nephropathy (IMN). In the present study, autophagic activity and lysosomal alterations were investigated in podocytes of IMN patients and in ...
Wei Jing Liu, Zhi-hang Li, Xiao-cui Chen, Xiao-lu Zhao, Zhen Zhong, Chen Yang, Hong-luan Wu, Ning An, Wei-yan Li, Hua-feng Liu   +9 more
doaj   +1 more source

Serum klotho level as an indicator for predicting the progression of renal function in chronic kidney disease stages 3~5

Di-san junyi daxue xuebao, 2020
Objective To investigate the association of serum klotho level with renal function deterioration and whether serum klotho level can be used as a predictor of progression of chronic kidney disease (CKD) into renal end point events.
YANG Jiangxin, XIONG Jiachuan, YANG Ke, ZHAO Jinghong   +3 more
doaj   +1 more source

AMP-activated protein kinase α2 contributes to acute and chronic hyperuricemic nephropathy via renal urate deposition in a mouse model

European Journal of Medical Research, 2022
Hyperuricemia can induce acute and chronic kidney damage, but the pathological mechanism remains unclear. The potential role of AMP-activated protein kinase (AMPK) α2 in hyperuricemia-induced renal injury was investigated in this study. Acute and chronic
Chen Yang, Hong-yong Su, Ning An, Hong-luan Wu, Xiao-yan Guo, Zhi-hang Li, Xiao-cui Chen, Shao-ping Zhu, Dan Wu, Hui-yuan Li, Qing-jun Pan, Dong Liang, Hua-feng Liu   +12 more
doaj   +1 more source

Hydroxychloroquine administration exacerbates acute kidney injury complicated by lupus nephritis

Arthritis Research & Therapy, 2022
Background Hydroxychloroquine (HCQ) has been recommended as a basic treatment for lupus nephritis (LN) during this decade based on its ability to improve LN-related renal immune-mediated inflammatory lesions.
Ning An, Chen Yang, Hong-Luan Wu, Yun Guo, Xi-Jie Huang, Tong-Sheng Huang, Zhi-Hong Wu, Jing Xue, Rui-Hong Chen, Zhi-Hang Li, Qing-Jun Pan, Hua-Feng Liu   +11 more
doaj   +1 more source

Acute kidney disease and renal recovery : consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup [PDF]

, 2017
Consensus definitions have been reached for both acute kidney injury (AKI) and chronic kidney disease (CKD) and these definitions are now routinely used in research and clinical practice.
A Dewitte, A Ishani, A Ishani, A Morden, AB Pai, AG Schneider, AJ Lewington, Alexander Zarbock, AM Patel, AS Levey, Azra Bihorac, B Rodriguez-Iturbe, B Rodriguez-Iturbe, BB Newsome, BJ Philips, BS Moffett, C Mudumbai, C Ronco, C Vinsonneau, C-T Chao, CC Shiao, CJ Kirwan, Claudio Ronco, CM Bell, CM Horkan, CY Hsu, CY Hsu, D Korenkevych, D Ponce, D Schnell, David Bittleman, Dinna Cruz, DM Thomas, DW Brown, E Wang, EA Coleman, EA Hoste, EA Hoste, EA Hoste, ED Siew, ED Siew, ED Siew, ED Siew, ED Siew, Edward D. Siew, Eric Hoste, ES Kirkendall, Etienne Macedo, F Lapi, FG Brivet, GV do Nascimento, H de Geus, H Graf, H Schiffl, HL Smets, I Benz-de Bretagne, I Koulouridis, I Nachtigall, ID Bucaloiu, IH Khan, J Bouchard, J Bouchard, J Herrera, J Herrera, J Kaufman, J Zavada, JA Kellum, JA Kellum, JA Kellum, JA Kellum, Jay Koyner, JF Platt, JJ Dixon, JO Friedrich, John A. Kellum, JP Bosch, JP Nicholson, JR Brown, JR Brown, JR Prowle, JW Pickering, JW Pickering, K Doi, K Solez, Kathleen D. Liu, KD Liu, KR Pechman, L Cox, LA Tomlinson, Lakhmir S. Chawla, LJ Hickson, LS Chawla, LS Chawla, LS Chawla, LS Chawla, LS Chawla, Lui Forni, M Carlier, M Darmon, M Heung, M Heung, M Huber, M James, M Jun, M Monseu, M Xie, MA Onuigbo, Marlies Ostermann, MB Kwong, ME Matheny, Mitchell Rosner, Mitra Nadim, MM Chrymko, MM Sood, MT James, MT James, N Pannu, N Srisawat, Neesh Pannu, P Sharma, PA Duran, Patrick Murray, Paul M. Palevsky, PH van der Voort, PK Tao Li, PM Palevsky, PM Palevsky, R Cartin-Ceba, R Chu, R Jelliffe, R Rivosecchi, R Wald, R Wald, RA Parker, Ravindra Mehta, Rinaldo Bellomo, RK Basu, RL Amdur, RL Mehta, Robert L. Fitzgerald, Ron Wald, S Chen, S Ftouh, S Ninet, S Perinel, S Uchino, S Uchino, SA Silver, Sandra L. Kane-Gill, SC Gautam, Sean M. Bagshaw, SG Coca, SG Coca, SL Goldstein, SL Goldstein, SL Hu, SL Kane-Gill, SM Bagshaw, SM Handler, SM Jang, SM Lee, SM Moran, SP Kelleher, Stuart L. Goldstein, TJ Pianta, TY Wu, VC Wu, VC Wu, W Picard, Z Harel, ZH Endre, ZH Endre, ZL Cox, Zoltan Endre   +173 more
core   +2 more sources

ACE2 deficiency exacerbates obesity-related glomerulopathy through its role in regulating lipid metabolism

Cell Death Discovery, 2022
Obesity-related glomerulopathy is a secondary glomerular disease and its incidence has been increased globally in parallel with the obesity epidemic. ORG emerged as a growing cause of end-stage renal disease in recent years.
Yin-Yin Chen, Han Hong, Yu-Ting Lei, Jia Zou, Yi-Ya Yang, Li-Yu He   +5 more
doaj   +1 more source