Results 21 to 30 of about 2,031,859 (234)
Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease
Cells, 2022 The kidney contains many mitochondria that generate ATP to provide energy for cellular processes. Oxidative stress injury can be caused by impaired mitochondria with excessive levels of reactive oxygen species.
Hsin-Jung Ho, H. Shirakawa
semanticscholar +1 more source
Wasting in chronic kidney disease [PDF]
Journal of Cachexia, Sarcopenia and Muscle, 2011 Wasting/cachexia is prevalent among patients with chronic kidney disease (CKD). It is to be distinguished from malnutrition, which is defined as the consequence of insufficient food intake or an improper diet. Malnutrition is characterized by hunger, which is an adaptive response, whereas anorexia is prevalent in patients with wasting/cachexia.
Kamyar Kalantar-Zadeh +8 more
openaire +5 more sources
Journal of Atherosclerosis and Thrombosis, 2014 Chronic kidney disease is a condition that affects thousands of children all over the world, compromising their health and quality of life. Recent epidemiological studies have provided evidence suggesting that the number of patients is expected to grow.
Mencarelli F., Busutti M., Montini G.
openaire +4 more sources
Frontiers in Physiology, 2021 Mitochondria are known to generate approximately 90% of cellular reactive oxygen species (ROS). The imbalance between mitochondrial reactive oxygen species (mtROS) production and removal due to overproduction of ROS and/or decreased antioxidants defense ...
Hasna Tirichen +5 more
semanticscholar +1 more source
Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences
International Journal of Molecular Sciences, 2021 Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix as a response to different types of tissue injuries, which leads to organ dysfunction.
Sara Panizo +8 more
semanticscholar +1 more source
Autophagy in Chronic Kidney Diseases [PDF]
Cells, 2019 Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis. In clinical studies, autophagy activations and inhibitions are linked to acute kidney injuries, chronic kidney diseases, diabetic ...
Victor Chien-Chia Wu +3 more
openaire +4 more sources
Chronic Kidney Disease Diagnosis and Management: A Review.
Journal of the American Medical Association (JAMA), 2019 Importance Chronic kidney disease (CKD) is the 16th leading cause of years of life lost worldwide. Appropriate screening, diagnosis, and management by primary care clinicians are necessary to prevent adverse CKD-associated outcomes, including ...
Teresa K. Chen +2 more
semanticscholar +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
HDL and chronic kidney disease
Atherosclerosis Plus, 2023 Low HDL-cholesterol (HDL-C) concentrations are a typical trait of the dyslipidemia associated with chronic kidney disease (CKD). In this condition, plasma HDLs are characterized by alterations in structure and function, and these particles can lose their atheroprotective functions, e.g., the ability to promote cholesterol efflux from peripheral cells ...
Pavanello, Chiara, Ossoli, Alice
openaire +3 more sources
Novel and unscrutinized immune entities of the zebrafish gut
FEBS Letters, EarlyView.Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil +5 more
wiley +1 more source