Results 31 to 40 of about 855,465 (305)

The Podocyte in Diabetic Kidney Disease

The Scientific World Journal, 2009
Approaching epidemic levels, diabetic kidney disease (DKD) is now the leading cause of end-stage renal disease (ESRD). Microalbuminuria is an early clinical marker of DKD that results from damage to the glomerular filtration barrier at the level of the ...
Erin Stitt-Cavanagh, Laura MacLoed, Chris R.J. Kennedy   +2 more
doaj   +1 more source

The effect of the association between CETP variant type and alcohol consumption on cholesterol level differs according to the ALDH2 variant type

Scientific Reports, 2022
Alcohol consumption is associated with a high increased lipid profile and this association may depend on genetic risk factors. In this study, we aimed to assess the effects of genetic variation associated with alcohol consumption on lipid profiles using ...
Min-Gyu Yoo, Ji Ho Yun, Soo Kyung Koo, Hye-Ja Lee   +3 more
doaj   +1 more source

AMP-activated protein kinase α2 contributes to acute and chronic hyperuricemic nephropathy via renal urate deposition in a mouse model

European Journal of Medical Research, 2022
Hyperuricemia can induce acute and chronic kidney damage, but the pathological mechanism remains unclear. The potential role of AMP-activated protein kinase (AMPK) α2 in hyperuricemia-induced renal injury was investigated in this study. Acute and chronic
Chen Yang, Hong-yong Su, Ning An, Hong-luan Wu, Xiao-yan Guo, Zhi-hang Li, Xiao-cui Chen, Shao-ping Zhu, Dan Wu, Hui-yuan Li, Qing-jun Pan, Dong Liang, Hua-feng Liu   +12 more
doaj   +1 more source

Bisphenol A in Chronic Kidney Disease [PDF]

International Journal of Nephrology, 2013
Phenols are uremic toxins of intestinal origin formed by bacteria during protein metabolism. Of these molecules, p-cresol is the most studied and has been associated with renal function impairment and vascular damage. Bisphenol A (BPA) is a molecule with structural similarity with phenols found in plastic food and beverage containers as well as in some
Emilio González-Parra, Jose Antonio Herrero, Usama Elewa, Ricardo J. Bosch, Alberto Ortiz Arduán, Jesus Egido   +5 more
openaire   +4 more sources

Serum klotho level as an indicator for predicting the progression of renal function in chronic kidney disease stages 3~5

Di-san junyi daxue xuebao, 2020
Objective To investigate the association of serum klotho level with renal function deterioration and whether serum klotho level can be used as a predictor of progression of chronic kidney disease (CKD) into renal end point events.
YANG Jiangxin, XIONG Jiachuan, YANG Ke, ZHAO Jinghong   +3 more
doaj   +1 more source

Blockage of the lysosome-dependent autophagic pathway contributes to complement membrane attack complex-induced podocyte injury in idiopathic membranous nephropathy

Scientific Reports, 2017
Dysregulation of autophagy-mediated podocyte homeostasis is proposed to play a role in idiopathic membranous nephropathy (IMN). In the present study, autophagic activity and lysosomal alterations were investigated in podocytes of IMN patients and in ...
Wei Jing Liu, Zhi-hang Li, Xiao-cui Chen, Xiao-lu Zhao, Zhen Zhong, Chen Yang, Hong-luan Wu, Ning An, Wei-yan Li, Hua-feng Liu   +9 more
doaj   +1 more source

Hydroxychloroquine administration exacerbates acute kidney injury complicated by lupus nephritis

Arthritis Research & Therapy, 2022
Background Hydroxychloroquine (HCQ) has been recommended as a basic treatment for lupus nephritis (LN) during this decade based on its ability to improve LN-related renal immune-mediated inflammatory lesions.
Ning An, Chen Yang, Hong-Luan Wu, Yun Guo, Xi-Jie Huang, Tong-Sheng Huang, Zhi-Hong Wu, Jing Xue, Rui-Hong Chen, Zhi-Hang Li, Qing-Jun Pan, Hua-Feng Liu   +11 more
doaj   +1 more source

Aortic calcification and femoral bone density are independently associated with left ventricular mass in patients with chronic kidney disease [PDF]

, 2012
Background Vascular calcification and reduced bone density are prevalent in chronic kidney disease and linked to increased cardiovascular risk. The mechanism is unknown.
Moody William E., Edwards, Nicola C., Crabtree Nicola J., Steeds, Richard P., Colin D Chue, Chue, Colin D., Steeds Richard P., Ferro Charles J., Charles J Ferro, Nadezhda A Wall, Townend, Jonathan N., Ferro, Charles J., Zehnder Daniel, Zehnder, Daniel, Daniel Zehnder, Moody, William E., Chue Colin D., Edwards Nicola C., Nicola C Edwards, Richard P Steeds, Jonathan N Townend, Wall Nadezhda A., Nicola J Crabtree, William E Moody, Crabtree, Nicola J., Wall, Nadezhda A., Townend Jonathan N.   +26 more
core   +1 more source

ACE2 deficiency exacerbates obesity-related glomerulopathy through its role in regulating lipid metabolism

Cell Death Discovery, 2022
Obesity-related glomerulopathy is a secondary glomerular disease and its incidence has been increased globally in parallel with the obesity epidemic. ORG emerged as a growing cause of end-stage renal disease in recent years.
Yin-Yin Chen, Han Hong, Yu-Ting Lei, Jia Zou, Yi-Ya Yang, Li-Yu He   +5 more
doaj   +1 more source

Hepatitis B and C co-Infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults [PDF]

, 2012
Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-positive individuals. Hepatitis C (HCV) co-infection has been associated with increased risk of CKD, but prior studies lack information on potential mechanisms.
Bickel, M, ESPRIT Study Group, Amanda Mocroft, Christina M Wyatt, Ross, Michael J., Aleksandra Szymczak, ESPRIT Study Group, Daniel Grint, Jens Lundgren, Ryom, Lene, Lene Ryom, Neuhaus, Jacqueline, Bickel, Markus, Szymczak, A, Peters, L, Jacqueline Neuhaus, Ross, MJ, Michael J Ross, Koirala, J, Neuhaus, J, Szymczak, Aleksandra, Mocroft, Amanda, Peters, Lars, Grint, D, Markus Bickel, Grint, Daniel, Wyatt, CM, Janak Koirala, INSIGHT SMART Study Group, Lundgren, Jens, Ross, Michael J, Koirala, Janak, Ryom, L, Mocroft, A, Lars Peters, Lundgren, J, Wyatt, Christina M, Wyatt, Christina M.   +37 more
core   +1 more source