Results 61 to 70 of about 2,456,607 (422)
Phenotype standardization for drug-induced kidney disease. [PDF]
, 2015 Drug-induced kidney disease is a frequent cause of renal dysfunction; however, there are no standards to identify and characterize the spectrum of these disorders.
Awdishu, Linda +8 more
core +2 more sources
Research progress on endoplasmic reticulum homeostasis in kidney diseases
Cell Death and Disease, 2023 The endoplasmic reticulum (ER) plays important roles in biosynthetic and metabolic processes, including protein and lipid synthesis, Ca2+ homeostasis regulation, and subcellular organelle crosstalk. Dysregulation of ER homeostasis can cause toxic protein
Dan Wu +8 more
doaj +1 more source
Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway
Lupus Science and Medicine, 2022 Objective Lupus nephritis (LN) is a major complication and cause of death among patients with SLE. This research used in vivo and in vitro experiments to explore the therapeutic potential of metformin in kidney injury from LN-induced inflammation.Methods
Dan Wu +13 more
doaj +1 more source
Hypertension Treatment for Patients with Advanced Chronic Kidney Disease [PDF]
, 2014 Chronic kidney disease is common and frequently complicated with hypertension. As a major modifiable risk factor for cardiovascular disease in this high risk population, treatment of hypertension in chronic kidney disease is of paramount importance.
Agarwal, Rajiv, Sinha, Arjun D.
core +1 more source
International Journal of Molecular Sciences, 2021 Uric acid (UA) is synthesized mainly in the liver, intestines, and vascular endothelium as the end product of an exogenous purine from food and endogenously from damaged, dying, and dead cells.
H. Yanai +3 more
semanticscholar +1 more source
Autophagy in Chronic Kidney Diseases [PDF]
Cells, 2019 Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis. In clinical studies, autophagy activations and inhibitions are linked to acute kidney injuries, chronic kidney diseases, diabetic ...
Victor Chien-Chia Wu +3 more
openaire +4 more sources
Benefit of Apabetalone on Plasma Proteins in Renal Disease. [PDF]
, 2018 Introduction:Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Gilham, Dean +11 more
core +2 more sources
Fibrosis in Chronic Kidney Disease: Pathogenesis and Consequences
International Journal of Molecular Sciences, 2021 Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix as a response to different types of tissue injuries, which leads to organ dysfunction.
Sara Panizo +8 more
semanticscholar +1 more source
HDL and chronic kidney disease
Atherosclerosis Plus, 2023 Low HDL-cholesterol (HDL-C) concentrations are a typical trait of the dyslipidemia associated with chronic kidney disease (CKD). In this condition, plasma HDLs are characterized by alterations in structure and function, and these particles can lose their atheroprotective functions, e.g., the ability to promote cholesterol efflux from peripheral cells ...
Pavanello, Chiara, Ossoli, Alice
openaire +3 more sources
Shared features of endothelial dysfunction between sepsis and its preceding risk factors (aging and chronic disease) [PDF]
, 2018 Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis,increasing vascular permeability, promoting activation of the coagulation cascade, tissue edema and compromising perfusion of vital organs. Aging and chronic diseases(hypertension,dyslipidaemia,diabetes mellitus,chronic kidney disease,cardiovascular disease ...
arxiv +1 more source