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The Gut-Kidney Axis in Chronic Kidney Diseases. [PDF]
Diagnostics (Basel)The gut–kidney axis represents the complex interactions between the gut microbiota and kidney, which significantly impact the progression of chronic kidney disease (CKD) and overall patient health. In CKD patients, imbalances in the gut microbiota promote the production of uremic toxins, such as indoxyl sulfate and p-cresyl sulfate, which impair renal ...
Tsuji K +6 more
europepmc +5 more sources
Nature Reviews Disease Primers, 2017 Chronic kidney disease (CKD) is defined by persistent urine abnormalities, structural abnormalities or impaired excretory renal function suggestive of a loss of functional nephrons. The majority of patients with CKD are at risk of accelerated cardiovascular disease and death.
Romagnani, Paola +8 more
+7 more sources
Primary Care: Clinics in Office Practice, 2020 Chronic kidney disease is encountered by the primary care physician, in no small part owing to the high rates of hypertension and diabetes, the 2 most common etiologies of chronic kidney disease in the United States. As a primary care physician, it is important to understand the epidemiology, pathophysiology, and evaluation methods of chronic kidney ...
Cornelia, Charles, Allison H, Ferris
openaire +6 more sources
The Lancet, 2021 Chronic kidney disease is a progressive disease with no cure and high morbidity and mortality that occurs commonly in the general adult population, especially in people with diabetes and hypertension. Preservation of kidney function can improve outcomes and can be achieved through non-pharmacological strategies (eg, dietary and lifestyle adjustments ...
Kalantar-Zadeh, Kamyar +4 more
openaire +4 more sources
Chronic kidney diseases and inflammation research: a bibliometric analysis [PDF]
Frontiers in MedicineWang H, Chen Y, Gou Y, Yang D, Xiong L.
exaly +2 more sources
The LancetGlobally, the prevalence of chronic kidney disease is estimated to be approximately 850 million cases, with approximately 4 million individuals needing kidney replacement therapy for kidney failure. By 2050, chronic kidney disease is projected to become the fifth leading underlying cause of death worldwide.
Herrington, WG +3 more
+9 more sources
Arteriolar hyalinosis and renal outcomes in patients with immunoglobulin A nephropathy
Renal Failure, 2022 Background The relationship between arteriolar hyalinosis and renal progression in immunoglobulin A nephropathy (IgAN) is not fully understood. We aimed to investigate the clinicopathological features and outcomes of IgAN with or without arteriolar ...
Yunzhu Shen +8 more
doaj +1 more source
Research progress on endoplasmic reticulum homeostasis in kidney diseases
Cell Death and Disease, 2023 The endoplasmic reticulum (ER) plays important roles in biosynthetic and metabolic processes, including protein and lipid synthesis, Ca2+ homeostasis regulation, and subcellular organelle crosstalk. Dysregulation of ER homeostasis can cause toxic protein
Dan Wu +8 more
doaj +1 more source
CPT1A protects against renal fibrosis in mouse model of diabetic kidney disease
陆军军医大学学报, 2023 Objective To determine the effect of carnitine palmitoyl-transferase 1A (CPT1A) on renal interstitial fibrosis in diabetic kidney disease (DKD). Methods A total of 16 4-week-old male C57BL/6 mice were randomly divided into Control (Ctrl) group (n=8) and ...
XIONG Li +4 more
doaj +1 more source
Disease-a-Month, 2015 In his review article in the March 2015 edition ofCME, Prof. A M Meyers refers to chronic kidneydisease as 'an important disease group that threatenshealth'. I fully concur with this observation andwish to go a step further and assert that kidneydisease, together with other related non-communicable diseases(NCDs), poses not only a threat to health but ...
Catherine E. Langston, Adam E. Eatroff
+14 more sources