Results 31 to 40 of about 424,534 (311)
BMC Nephrology, 2023 Background Kidney failure is one of the leading causes of morbidity and mortality worldwide. The incidence of kidney failure in Somalia has been increasing in recent years.
Hamze Ibrahim Rage +5 more
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Cardiorenal relationships in patients with chronic heart failure with preserved ejection fraction
Лечащий Врач, 2023 The combination of heart and kidney diseases caused by chronic heart failure and aggravated by kidney damage, called cardiorenal syndrome, is increasingly recognized as a critical pathological unit, leading to a worsening of the prognosis in patients ...
Yu. N. Panina, V. I. Vishnevsky
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cisplatin Induced Nephrotoxicity
مجله دانشگاه علوم پزشکی بیرجند, 2014 Cisplatin is a potent chemotherapy agent which is used to treat a broad spectrum of solid cancers. However, its clinical use is limited due to its nephrotoxicity with a decline in the glomerular filtration rate that occur in 15-30% of patients.
Seyed Seifollah Beladi Mousavi +1 more
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Commentary on the burden of chronic kidney disease
Ibom Medical Journal, 2012 The kidneys are two bean shaped organs situated in the abdomen that is responsible for the excretion of metabolic waste, production of hormones, and metabolism and excretion of drugs and toxins amongst others. Chronic renal failure is said to occur when
Unadike B
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Study the activity of Tryptase And Beta 2- Microglobulin Levels In the Sera of Patients With Chronic Renal Failure And Rheumatoid Arthritis [PDF]
Kirkuk Journal of Science, 2016 This work was mainly designed to study the levels of Mast Cell Tryptase & Beta 2- Microglobulin in serum of patients with chronic renal failure (CRF), which they were in the end stage of renal disease (ESDR) depending on hemodialysis (HD) and chronic ...
Sabah H. Khorsheed +2 more
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Frontiers in Cardiovascular MedicineBackgroundObesity or overweight is well known to be a strong risk factor for the development of hypertension. However, the association of body mass index (BMI) within the normal range and its trajectory with new-onset hypertension in adults remains ...
Hongxue Yu +42 more
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FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
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