Results 51 to 60 of about 717,360 (306)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Causes of kidney failure among patients undergoing maintenance hemodialysis in Somalia: a multi-center study

BMC Nephrology, 2023
Background Kidney failure is one of the leading causes of morbidity and mortality worldwide. The incidence of kidney failure in Somalia has been increasing in recent years.
Hamze Ibrahim Rage, Suleyman A Ers, Abdirazak Y Kahin, Muraad M Elmi, Abdiaziz A Mohamed, Pranaw Kumar Jha   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Acute kidney injury: an acceptable risk of treatment with renin-angiotensin system blockade in primary care? [PDF]

, 2015
Background: Use of renin-angiotensin system (RAS) blockade has become increasingly widespread driven by evidence-based guidance. There is concern about the role of these agents in the genesis of avoidable acute kidney injury (AKI).
Bellomo R, Kidney Disease: Improving Global Outcomes Chronic Kidney Disease Guideline Development Work Group Members, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence   +7 more
core   +5 more sources

Cisplatin Induced Nephrotoxicity

مجله دانشگاه علوم پزشکی بیرجند, 2014
Cisplatin is a potent chemotherapy agent which is used to treat a broad spectrum of solid cancers. However, its clinical use is limited due to its nephrotoxicity with a decline in the glomerular filtration rate that occur in 15-30% of patients.
Seyed Seifollah Beladi Mousavi, Abbas Ali Zeraati   +1 more
doaj  

Gambaran Kadar Kreatinin Serum Pada Pasien Penyakit Ginjal Kronik Stadium 5 Non Dialisis [PDF]

, 2016
: Chronic kidney disease is a pathophysiology process with various etiology, causing a progressive decline on kidney function, and in general ends with kidney failure (stage 5).
Alfonso, A. A. (Astrid), Memah, M. F. (Maya), Mongan, A. E. (Arthur)   +2 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of high normal body mass index and its trajectory on risk of new-onset hypertension among Chinese adults: a national prospective cohort study

Frontiers in Cardiovascular Medicine
BackgroundObesity or overweight is well known to be a strong risk factor for the development of hypertension. However, the association of body mass index (BMI) within the normal range and its trajectory with new-onset hypertension in adults remains ...
Hongxue Yu, Hongxue Yu, Hongxue Yu, Hongxue Yu, Hongxue Yu, Qi Gao, Qi Gao, Yuxin Lin, Yuxin Lin, Yuxin Lin, Yuxin Lin, Yuxin Lin, Fan Luo, Fan Luo, Fan Luo, Fan Luo, Fan Luo, Pingping Li, Pingping Li, Pingping Li, Pingping Li, Pingping Li, Yuping Zhang, Yuping Zhang, Yuping Zhang, Yuping Zhang, Yuping Zhang, Jiao Liu, Jiao Liu, Jiao Liu, Jiao Liu, Jiao Liu, Ruqi Xu, Yanqin Li, Yanqin Li, Yanqin Li, Yanqin Li, Yanqin Li, Licong Su, Licong Su, Licong Su, Licong Su, Licong Su   +42 more
doaj   +1 more source

Dietary patterns for adults with chronic kidney disease [PDF]

, 2015
This is the protocol for a review and there is no abstract. The objectives are as follows: This review will evaluate the benefits and harms of dietary patterns among adults with CKD (any stage including people with end-stage kidney disease (ESKD) treated
Campbell, Katrina Louise, Craig, Jonathan C, Johnson, David W, Maggo, Jasjot K, Palmer, Suetonia C, Ruospo, Marinella, Strippoli, Giovanni F M, Sutanto, Bernadet, Tong, Allison   +8 more
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source