Results 51 to 60 of about 4,245,701 (297)

Commentary on the burden of chronic kidney disease

Ibom Medical Journal, 2012
The kidneys are two bean shaped organs situated in the abdomen that is responsible for the excretion of metabolic waste, production of hormones, and metabolism and excretion of drugs and toxins amongst others. Chronic renal failure is said to occur when
Unadike B
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The cost of implementing UK guidelines for the management of chronic kidney disease [PDF]

, 2007
Background. Chronic kidney disease (CKD) is a major public health problem. In the UK, guidelines have been developed to facilitate case identification and management.
B. Klebe, Stevens, PE, H. Hobbs, Lamb, EJ, Cooley, R, Irving, J, Hobbs, H, D. J. O'Donoghue, Farmer, CKT, J. New, Middleton, R, S. de Lusignan, Klebe, B, J. Irving, O'Donoghue, DJ, John, I, R. Middleton, I. John, P. E. Stevens, R. Cooley, de Lusignan, S, New, J, C. K.T. Farmer, E. J. Lamb, Hobbs, Helen, John, Ian, Klebe, Bernhard, Middleton, Rachel, Stevens, Paul E., New, John, Cooley, Roger, Lamb, Edmund J., O'Donoghue, Donal J., Farmer, Chris, Irving, Jean, de Lusignan, Simon   +35 more
core   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Using Serum Interleukin-18 (IL-18) as a Biomarker of Chronic Kidney Failure and its relationship with Prolactin Level

Tikrit Journal of Pure Science, 2020
Kidney failure usually occurs as a result of lacking the normal functions of kidney as either partly or completely. In the last years, it was announced that the Interleukin-18 has received significant interest as inflame marker.
Wasan Abdul Malik Izz al-Din, , Nadia Ibrahim Salih   +1 more
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Correlation between Serum level of Troponin I and High Sensetive CRP in Renal transplant Patients

مجله دانشگاه علوم پزشکی بیرجند, 2013
Background and Aim: Accompaniment of high serum levels of CRP to troponin increases the mortality rate in dialysis patients, and both of them are considered to be independent risk factors for uremic cardiomyopathy.
Abbas Ali Zeraati, Farzaneh Sharifipour, Faezeh Rajabigol, Hourak Pourzand, Seyyed Seifollah Beladi Mousavi   +4 more
doaj  

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Biochemical parameters of rat blood in the models of chronic heart failure and chronic kidney disease at the administration of nitric oxide donor

BIO Web of Conferences, 2020
In modern veterinary medicine, the simultaneous occurrence of chronic heart failure and chronic kidney disease is often found. However, the cause and effect often exchange places, which creates great difficulties in the animals’ treatment. Chlofusan acts
Akhmadeeva Ksenia, Belova Alisa, Karimova Rufiia   +2 more
doaj   +1 more source