Results 41 to 50 of about 465,591 (312)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Pharmacology of Treatments and Managements of Acute and Chronic Kidney Failure

, 2023
This thesis describes the treatment of Acute and Chronic Kidney failure as well as it's management. Numerous illnesses and disorders have the potential to gradually or unexpectedly decrease kidney function.
Ebenezer, Tamunokuro Power
core  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Cisplatin Induced Nephrotoxicity

مجله دانشگاه علوم پزشکی بیرجند, 2014
Cisplatin is a potent chemotherapy agent which is used to treat a broad spectrum of solid cancers. However, its clinical use is limited due to its nephrotoxicity with a decline in the glomerular filtration rate that occur in 15-30% of patients.
Seyed Seifollah Beladi Mousavi, Abbas Ali Zeraati   +1 more
doaj  

Causes of kidney failure among patients undergoing maintenance hemodialysis in Somalia: a multi-center study

BMC Nephrology, 2023
Background Kidney failure is one of the leading causes of morbidity and mortality worldwide. The incidence of kidney failure in Somalia has been increasing in recent years.
Hamze Ibrahim Rage, Suleyman A Ers, Abdirazak Y Kahin, Muraad M Elmi, Abdiaziz A Mohamed, Pranaw Kumar Jha   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The spatial analysis of diagnosed Chronic Kidney Disease in Nigeria: A case study of Edo State [PDF]

, 2012
The thesis explores the severity of diagnosed chronic kidney disease (CKD) with particular reference to its impact in Edo state, Nigeria. There has been a scarcity of studies on the prevalence and spatial patterns of CKD in developing countries even ...
Oviasu, Osaretin
core  

Effect of information and telephone-guided access to community support for people with chronic kidney disease: randomised controlled trial

, 2014
BackgroundImplementation of self-management support in traditional primary care settings has proved difficult, encouraging the development of alternative models which actively link to community resources.
Peter Bower (52501), Christian Blickem, Christian Blickem (397641), Brooks Helen, Anne Rogers, Chew-Graham, C, Blakeman, T, Gerry Richardson (571072), Bower, P, David Reeves, Reeves, Davd, Blakeman, Tom, Dawson, S, Gaffney, H, Lee, V, David Reeves (164641), Mossabir Rahena, Tom Blakeman, Hannah Gaffney, Gardner Caroline, Reeves, D, Blickem, C, Victoria Lee, Bower, Peter; id_orcid, Hannah Gaffney (645995), Ivaylo Vassilev (397639), Blickem, Christian, Spackman, E, Anne Kennedy (397644), Victoria Lee (645997), Richardson, Gerry, Shoba Dawson (645999), Dawson Shoba, Helen Brooks (397642), Anne Rogers (397640), Mossabir, Rahena, Spackman, Eldon, Jariwala, P, Spackman Eldon, Shoba Dawson, Blakeman Tom, Gaffney Hannah, Gaffney, Hannah, Anne Kennedy, Praksha Jariwala, Mossabir, R, Vassilev Ivaylo, Chew-Graham Carolyn, Kennedy, A, Dawson, Shoba, Rahena Mossabir (646000), Vassilev, Ivaylo, Reeves, David, Helen Brooks, Praksha Jariwala (645998), Bower Peter, Richardson, G, Caroline Gardner, Jariwala Praksha, Brooks, Helen, Rogers, A, Reeves David, Caroline Gardner (645996), Brooks, H, Kennedy, Anne P., Peter Bower, Bower, Peter, Lee, Victoria, Carolyn Chew-Graham, Blakeman, Tom; id_orcid, Tom Blakeman (645994), Blickem Christian, Lee Victoria, Eldon Spackman, Rogers, Anne, Kennedy, Anne, Gardner, Caroline, Rogers Anne, Ivaylo Vassilev, Eldon Spackman (462402), Richardson Gerry, Gardner, C, Vassilev, I, Kennedy Anne, Rahena Mossabir, Jariwala, Praksha, Chew-Graham, Carolyn, Gerry Richardson, Carolyn Chew-Graham (615627)   +88 more
core   +1 more source

Acute kidney injury: an acceptable risk of treatment with renin-angiotensin system blockade in primary care? [PDF]

, 2015
Background: Use of renin-angiotensin system (RAS) blockade has become increasingly widespread driven by evidence-based guidance. There is concern about the role of these agents in the genesis of avoidable acute kidney injury (AKI).
Jean Irving, Paul E Stevens, Irving, Jean, Michael Bedford, Bedford, Michael, Stevens, Paul E., Christopher KT Farmer, Farmer, Christopher K.   +7 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source