Results 61 to 70 of about 4,245,701 (297)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Studi Penggunaan Obat Antihipertensi Pada Pasien Chronic Renal Failure

open access: yesIndonesian Journal of Pharmaceutical Education
Kidney failure is a world health problem with increasing prevalence, morbidity, and mortality rates. Kidney disease is divided into 2, acute kidney failure (acute kidney disease) and chronic kidney failure (chronic kidney disease). Hypertension occurs in
Ni Made Maharianingsih   +1 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao   +5 more
wiley   +1 more source

THE RELATIONSHIP BETWEEN FAMILY SOCIAL SUPPORT AND COMPLIANCE OF CHRONIC RENAL FAILURE PATIENTS UNDERGOING HEMODIALYSIS

open access: yesJournal of Vocational Nursing
Introduction: Chronic kidney disease is defined as kidney damage that lasts long (chronic) and is characterized by a decrease in the kidney's ability to filter blood (GFR).
Adhe Dewanto   +2 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Effect of information and telephone-guided access to community support for people with chronic kidney disease: randomised controlled trial [PDF]

open access: yes, 2014
BackgroundImplementation of self-management support in traditional primary care settings has proved difficult, encouraging the development of alternative models which actively link to community resources.
Peter Bower (52501)   +88 more
core   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali   +4 more
wiley   +1 more source

Skin changes in chronic kidney disease

open access: yes, 2017
Chronic kidney disease causes skin changes which may sometimes be the first sign of kidney failure. Specific skin changes include acquired perforating dermatosis, porphyria cutanea tarda, pseudoporphyria, calcinosis and nephrogenic systemic fibrosis. The
Joanna M. Przepiórka-Kosińska   +4 more
core   +1 more source

Genome-wide association and functional follow-up reveals new loci for kidney function [PDF]

open access: yes, 2012
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new
Döring, Angela   +999 more
core   +1 more source

MECHANISMS OF THE KIDNEY DAMAGE IN CASE OF OBESITY AND METABOLIC SYNDROME (REVIEW)

open access: yesМать и дитя в Кузбассе, 2018
Obesity and metabolic syndrome influence the functions of body’s systems, provoke a progressive kidney damage and are development factors of chronic nephron number in reference to body mass. A long-term impact of these factors leads to glomerulosclerosis
Юлия Николаевна Шишкова   +3 more
doaj  

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