Results 211 to 220 of about 795,396 (307)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Chronic Liver Disease Associated Cholangiocarcinoma: Genomic Insights and Precision Therapeutic Strategies. [PDF]

Cancers (Basel)
Oura K, Morishita A, Nakahara M, Tadokoro T, Fujita K, Tani J, Masaki T, Kobara H.   +7 more
europepmc   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Acute kidney injury in chronic liver disease: Causes and prevalence in a cross-sectional study. [PDF]

Bioinformation
Gupta PK, Soni R, Bandil Y, Dhurvey MSS, Parmar S.   +4 more
europepmc   +1 more source

Drug-Induced Chronic Liver Disease

Gastroenterology, 1977
W C, Maddrey, J K, Boitnott
openaire   +2 more sources

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Expert Consensus on Clinical Applications of Fecal Microbiota Transplantation for Chronic Liver Disease (2025 edition). [PDF]

J Clin Transl Hepatol
Zhou Y, Yang L, Nan Y, Liver Related Digestive Diseases Group, Chinese Society of Hepatology, Chinese Medical Association.   +5 more
europepmc   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

COVID-19 and chronic liver disease: results from the 1219 patients French registry. [PDF]

Sci Rep
Blaise L, Lebossé F, Costentin C, Ahmed SS, Heurgué A, Fontaine H, Meszaros M, Radenne S, Vanlemmens C, Landrieux A, Bouzbib C, Barraud H, Bardou-Jacquet E, Chazouillères O, Latournerie M, Rosa I, Anty R, Gelu-Simeon M, Khaldi M, Amaddeo G, Lemaitre C, Bernard-Chabert B, Moga L, Roulot-Marullo D, Elkrief L, Boursier J, Plessier A, Bureau C, Pageaux GP, Rémy AJ, Sultanik P, de Ledinghen V, Reboux N, Texier F, Hiriart JB, Montialoux H, de Montigny S, Rudler M, Williet N, Talib Z, Mboup B, Bourlière M, Vicaut E, Ganne-Carrié N, Dumortier J.   +44 more
europepmc   +1 more source

Anaemia in chronic liver disease

, 1964
Carlien L. Kimber
openalex   +1 more source