Results 101 to 110 of about 1,217,515 (309)

Maintaining lung health with longstanding HIV [PDF]

, 2016
Purpose of review: Human immunodeficiency virus (HIV) is now managed as a chronic disease. Non-infectious pulmonary conditions have replaced infection as the biggest threat to lung health, particularly as HIV cohorts age, but there is no consensus on how
Aberg, Almodovar, Amsellem, Araujo, Attia, Aukrust, Borges, Boutten, Buhl, Buzon, Caldwell, Cicalini, Clausen, Coghill, Correale, Cota-Gomez, Cribbs, Cribbs, Crothers, Crothers, Crothers, Cui, Currier, Dalvi, Dalvi, Degano, Diaz, Diaz, Diaz, Diaz, Drummond, Engels, Fan, Feijoo, Fisher, Fishman, Fitzpatrick, George, George, Gingo, Gingo, Gingo, Gingo, Green, Guiguet, Gundavarapu, Helleberg, Hirani, Hodge, Hogg, Horiike, Hulbert, Isasti, Kanmogne, Kanmogne, Kirk, Kristoffersen, Lambert, Lassiter, Leung, Liu, Lozupone, Madeddu, Makinson, Marcus, Marecki, McQuillan, Mermis, Mitchell, Morris, National Lung Screening Trial Research, Opravil, Opravil, Pacht, Parikh, Patel, Peacock, Pefura-Yone, Popescu, Porter, Quezada, Reekie, Reinsch, Rosen, Samperiz, Sangal, Santangelo, Schwarcz, Schwarze-Zander, Secemsky, Selby, Sharma, Shebl, Sheth, Shiels, Shiels, Shirley, Sigel, Sigel, Sitbon, Speich, Sze, Tcherakian, ten Freyhaus, Vandenhende, Wanchu, Worm, Yearsley, Zheng   +108 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

COPD: Optimizing Treatment [PDF]

, 2015
A guideline update and an expanded armamentarium have many physicians wondering how best to treat patients with COPD. Chronic obstructive pulmonary disease (COPD) carries a high disease burden. In 2012, it was the 4th leading cause of death worldwide.1,2
Ahmed-Sarwar, Nabila, Holub, David C, Pierce, Deirdre P   +2 more
core   +1 more source

Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease. [PDF]

, 2014
The etiology of persistent lung inflammation in preterm infants with chronic lung disease of prematurity (CLD) is poorly characterized, hampering efforts to stratify prognosis and treatment. Airway macrophages are important innate immune cells with roles
A Kotiranta-Ainamo, AE Currie, BJ Zeligs, BJ Zeligs, BW Kramer, BW Parks, C Haslett, D Chantry, David H. Dockrell, DH Bowden, E Alenghat, E Forster-Waldl, Eamon P. McGreal, ER Unanue, F Genel, F Kanakoudi-Tsakalidou, G Fingerle, G Kurland, H Arai, HM Marriott, HW Ziegler-Heitbrock, HW Zimmermann, HY Huh, Ian Sabroe, J Grigg, J Savill, JA Bellanti, JM Cavaillon, JM Grigg, K Asada, K Dhaliwal, L Landsman, L Ziegler-Heitbrock, LJ Van Marter, Lynne R. Prince, M Daigneault, M Iwahashi, M Zhang, ML Huynh, Moira K. Whyte, NE Alexis, Nicola C. Maxwell, NS Dessardo, O Grip, Oliver Eickelberg, P Antal-Szalmas, PL Davies, R Andreesen, RL Kradin, S Knapp, S Kotecha, S Kotecha, S Rosseau, SA Renshaw, Sailesh Kotecha, SB Gordon, Sharonjit K. Gill, T Ganz, TS Blackwell, U Hallwirth, VA Fadok, WS Driscoll   +61 more
core   +4 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Role of Innate Lymphoid Cells in Lung Disease

Iranian Journal of Allergy, Asthma and Immunology, 2015
Innate lymphoid cells (ILCs) are identified as novel population of hematopoietic cells which protect the body by coordinating the innate immune response against a wide range of threats including infections, tissue damages and homeostatic disturbances ...
Sayed Mehran Marashian, Esmaeil Mortaz, Hamid Reza Jamaati, Mostafa Alavi-Moghaddam, Arda Kiani, Atefeh Abedini, Johan Garssen, Ian M.Adcock, Ali Akbar Velayati   +8 more
doaj  

Pulmonary Hypertension in Chronic Lung Diseases

Journal of the American College of Cardiology, 2013
Chronic obstructive lung disease (COPD) and diffuse parenchymal lung diseases (DPLD), including idiopathic pulmonary fibrosis (IPF) and sarcoidosis, are associated with a high incidence of pulmonary hypertension (PH), which is linked with exercise limitation and a worse prognosis.
Seeger, Werner, Adir, Yochai, Albert Barbera, Joan, Champion, Hunter, Coghlan, John Gerard, Cottin, Vincent, de Marco, Teresa, Galiè, Nazzareno, Ghio, Stefano, Gibbs, Simon, Martinez, Fernando J., Semigran, Marc J., Simonneau, Gérald, Wells, Athol U., Vachiery, Jean-Luc   +14 more
openaire   +5 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source