Results 81 to 90 of about 782,946 (316)

Chronic interstitial lung disease in children

open access: yesJornal de Pediatria, 2007
Interstitial lung diseases (ILDs) in children constitute a heterogeneous group of rare diseases that have been described and classified according to experiences and research in adults. However, pediatric pulmonologists have observed that the clinical spectrum is broader in children than in adults, and that many of these disorders have different courses
Maria Aparecida S S, Paiva   +1 more
openaire   +3 more sources

Monitoring pulmonary rehabilitation and long-term oxygen therapy for people with chronic obstructive pulmonary disease (COPD) [PDF]

open access: yes, 2013
This report outlines a proposed approach to monitoring access to, and utilisation of, pulmonary rehabilitation and long term oxygen therapy, by capitalising on existing data sources and identifying data development opportunities.SummaryChronic ...
Guy Marks
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Eighty Kilograms Weight Reduction in a Case of Obstructive Sleep Apnea with Several Comorbidities: Did the Conditions Improve?

open access: yesActa Medica Iranica, 2016
Obstructive sleep apnea (OSA) together with metabolic disorders is common in severely obese patients. Weight reduction is considered as a treatment modality in these cases while few of them can succeed in considerable weight loss.
Moein Foroughi   +2 more
doaj  

Application of artificial neural network model in studying the mechanism of disease relapse event in patients with tuberculosis [PDF]

open access: yesHealth Science Monitor, 2022
Background & Aims: Today, due to progressing technology and improving the standard of living of humans, the study of diseases has become more complex.
Mehdi Kazempour Dizaji   +12 more
doaj  

Preventing Chronic Disease (PCD) [PDF]

open access: yes
This collection of articles in Preventing Chronic Disease (PCD) brings together scientists and practitioners from the breadth of public health and the social sciences to demonstrate how geospatial perspectives can contribute to understanding and ...

core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Local lung responses following endobronchial elastase and lipopolysaccharide instillation in sheep

open access: yes, 2006
Chronic lipopolysaccharide (LPS) exposure may contribute to the pathogenesis of a number of lung diseases including COPD and emphysema. We sought to develop a large-animal model of emphysema using repeated LPS administration into sheep lung segments.
Blundell, Richard   +8 more
core   +1 more source

Acute and Chronic Effects of Smoking on Inflammation Markers in Exhaled Breath Condensate in Current Smokers [PDF]

open access: yes, 2010
Background: Long-term cigarette smoking is associated with pulmonary inflammation, but the acute effects of smoking have been less well studied. Analysis of the exhaled breath condensate (EBC) can provide noninvasive markers that might be indicative of ...
Römmelt, Horst   +6 more
core   +1 more source

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