Results 71 to 80 of about 782,946 (316)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Early life origins of lung ageing : early life exposures and lung function decline in adulthood in two European cohorts aged 28-73 years [PDF]

, 2015
Early life environment is essential for lung growth and maximally attained lung function. Whether early life exposures impact on lung function decline in adulthood, an indicator of lung ageing, has scarcely been studied.; Spirometry data from two time ...
Svanes, C., Dratva, J., Norbäck D, Dan Norbäck (2143342), Villani, S., Gómez Real, Francisco, Dan Norbäck, Real, Francisco Gómez, Marco, Roberto de, Janson C, Dharmage, Shyamali C, Burdet, L., Jarvis, D, Villani S, de Marco, Roberto, Zemp, E., Accordini, Simone, Roberto de Marco, Julia Dratva, Elisabeth Zemp (142900), Accordini, S., Zemp, E, Deborah Jarvis (59834), Norbäck, D., Probst-Hensch, Nicole, Zemp, Elisabeth, Zemp, Elisabeth,, Probst-Hensch, N, Deborah Jarvis, Shyamali C. Dharmage (131486), Simona Villani, Pons, M, Joachim Heinrich (60421), Dharmage, S.C., Burdet, Luc, Luc Burdet (848789), Sunyer Deu, Jordi, Sunyer J, Accordini, Simone,, de Marco R, Dratva, Julia,, Jarvis, Deborah,, Simone Accordini (411992), Heinrich, Joachim,, Svanes, C, Marco Pons (848790), Dratva, J, Roberto de Marco (370210), Probst Hensch, Nicole, Christer Janson, Cecilie Svanes (59836), Thorarinn Gislason (508297), Heinrich, Joachim, Norbäck, Dan, Pons, M., Elisabeth Zemp, Heinrich, J., Julia Dratva (748527), Luc Burdet, Jarvis, Deborah, Villani, Simona, Nicole Probst-Hensch (520032), Real, FG, Jordi Sunyer, Dharmage SC, Villani, Simona,, Jarvis, D., de Marco, R., Dratva J, Accordini S, Pons M, Gislason, T., Probst-Hensch, N., Zemp E, Christer Janson (83414), Sunyer, J., Gislason, Thorarinn, Francisco Gómez Real (769225), Dharmage, Shyamali C.,, Real, Francisco Gomez,, Sunyer, Jordi,, Janson, Christer,, Sunyer, J, Janson, C., Thorarinn Gislason, Jarvis D, Svanes C, de Marco, Roberto,, Janson, C, Norback, D, Cecilie Svanes, Simona Villani (59831), de Marco, R, Burdet, Luc,, Pons, Marco,, Francisco Gómez Real, Real FG, Gislason, Thorarinn,, Shyamali C Dharmage, Norbäck, Dan,, Heinrich, J, Real, F.G., Simone Accordini, Joachim Heinrich, Janson, Christer, Dharmage, Shyamali C., Dratva, Julia, Jordi Sunyer (59833), Probst-Hensch N, Dharmage, SC, Pons, Marco, Sunyer, Jordi, Accordini, S, Gislason, T, Gislason T, Heinrich J, Svanes, Cecilie,, Villani, S, Probst-Hensch, Nicole,, Svanes, Cecilie, Nicole Probst-Hensch, Burdet, L, Marco Pons, Burdet L   +123 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Silent hypoxia: higher NO in red blood cells of COVID-19 patients

BMC Pulmonary Medicine, 2020
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has spread to almost 100 countries, infected over 31 M patients and resulted in 961 K deaths worldwide as of 21st September 2020.
Esmaeil Mortaz, Majid Malkmohammad, Hamidreza Jamaati, Parisa Adimi Naghan, Seyed MohamadReza Hashemian, Payam Tabarsi, Maohammad Varahram, Hamidreza Zaheri, Efsun Gonca Uğur Chousein, Gert Folkerts, Ian M. Adcock   +10 more
doaj   +1 more source

Metabolic Disorders in Chronic Lung Diseases

Frontiers in Medicine, 2018
Chronic lung diseases represent complex diseases with gradually increasing incidence, characterized by significant medical and financial burden for both patients and relatives. Their increasing incidence and complexity render a comprehensive, multidisciplinary, and personalized approach critically important.
Ourania Papaioannou, Theodoros Karampitsakos, Ilianna Barbayianni, Serafeim Chrysikos, Nikos Xylourgidis, Vasilis Tzilas, Demosthenes Bouros, Vasilis Aidinis, Argyrios Tzouvelekis, Argyrios Tzouvelekis   +9 more
openaire   +4 more sources

Clinical, morphological and molecular characterization of cancer phenotypes associated with chronic obstructive pulmonary disease (COPD): new prospective of target therapies [PDF]

, 2013
BACKGROUND Chronic obstructive pulmonary disease (COPD) and lung cancer are two catastrophic diseases, representing leading causes of morbidity and mortality worldwide.
Schiavon, Marco
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Takotsubo Cardiomyopathy Secondary to Lung Transplantation Followed by Reduced Ejection Fraction Heart Failure: A Case Report

Clinical Case Reports
Takotsubo cardiomyopathy (TTC) is characterized by acute, transient left ventricular systolic dysfunction with regional wall‐motion abnormalities. It is a form of stress‐induced cardiomyopathy and can happen due to emotional or physical stress.
Azadeh Moradkhani, Masoume Avateffazeli, Farah Naghashzadeh, Salman Soleimani, Zargham Hossein Ahmadi, Alireza Jahangiri Fard, Sina Homaee, Mohammad Varahram, Mahshid Hajiali, Shadi Shafaghi, Atefeh Abedini   +10 more
doaj   +1 more source

Correction to: Silent hypoxia: higher NO in red blood cells of COVID-19 patients

BMC Pulmonary Medicine, 2020
An amendment to this paper has been published and can be accessed via the original article.
Esmaeil Mortaz, Majid Malkmohammad, Hamidreza Jamaati, Parisa Adimi Naghan, Seyed Mohamad Reza Hashemian, Payam Tabarsi, Maohammad Varahram, Hamidreza Zaheri, Efsun Gonca Uğur Chousein, Gert Folkerts, Ian M. Adcock   +10 more
doaj   +1 more source