Results 61 to 70 of about 782,946 (316)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces

Nature Communications, 2020
Surgical adhesions are organ-joining bands of scar tissue that remain clinically untreatable. Here, the authors show that adhesions are formed through expansive mesothelial membrane bridges, and that blocking these with small molecules prevents formation
Adrian Fischer, Tim Koopmans, Pushkar Ramesh, Simon Christ, Maximilian Strunz, Juliane Wannemacher, Michaela Aichler, Annette Feuchtinger, Axel Walch, Meshal Ansari, Fabian J. Theis, Kenji Schorpp, Kamyar Hadian, Philipp-Alexander Neumann, Herbert B. Schiller, Yuval Rinkevich   +15 more
doaj   +1 more source

Pulmonary Hypertension in Chronic Lung Diseases

Journal of the American College of Cardiology, 2013
Chronic obstructive lung disease (COPD) and diffuse parenchymal lung diseases (DPLD), including idiopathic pulmonary fibrosis (IPF) and sarcoidosis, are associated with a high incidence of pulmonary hypertension (PH), which is linked with exercise limitation and a worse prognosis.
Seeger, Werner, Adir, Yochai, Albert Barbera, Joan, Champion, Hunter, Coghlan, John Gerard, Cottin, Vincent, de Marco, Teresa, Galiè, Nazzareno, Ghio, Stefano, Gibbs, Simon, Martinez, Fernando J., Semigran, Marc J., Simonneau, Gérald, Wells, Athol U., Vachiery, Jean-Luc   +14 more
openaire   +6 more sources

Influence of lung function on course of disease and response to antibiotic therapy in adult primary care patients with acute cough: a post hoc analysis of patients enrolled in a prospective multicentre study

, 2014
BACKGROUND: In acute cough patients, impaired lung function as present in chronic lung conditions like asthma and chronic obstructive pulmonary disease (COPD) are often thought to negatively influence course of disease, but clear evidence is lacking.AIMS:
Verheij, Theo J M, Leven, Margareta, Moore, Michael, Verheij, TJ, Thomas, Mike, Verheij, Theo J.M., Stuart, B, Hood, K, Coenen, Samuel, Stuart, Beth, Goossens, Herman, Goossens, H, Little, Paul, Moore, M, Coenen, S, Little, P, van Erp, Nicole, Thomas, M, Hood, Kerenza, van Erp, N, Butler, Chris C., Butler, CC, Leven, M   +22 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Modeling the survival of patients with tuberculosis based on the model of artificial neural networks [PDF]

Health Science Monitor, 2022
Background & Aims:  The development of treatment methods and increasing the survival of patients with tuberculosis (TB) has led to the complication of relationships between independent and dependent variables associated with this disease.
Mehdi Kazempour Dizaji, Majid Marjani, Payam Tabarsi, Mohammad Varahram, Ali Zare, Mohammad Ali Emamhadi, Rahim Roozbahani, Atefe Abedini, Parvane h Baghaei Shiva, Afshin Moniri, Mohammadreza Madani   +10 more
doaj  

The Role of Hemoperfusion in COVID-19 Infection: A Case Series

Archives of Anesthesia and Critical Care, 2021
The rapid expansion of a novel human infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a pandemic, affecting thousands of people world wild.
Ali Amirsavadkouhi, Alireza Jahangirifard, Reza Shahrami, Saeid Safari, Faezeh Feizabadi, Zahra Mirshafiei Mirshafiei Langari, Alireza Dastan, Seyed Bashir Mirtajani, Shayan Ghaznavi, Farzaneh Dastan   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Cigarette Smoke Affects Dendritic Cell Populations, Epithelial Barrier Function, and the Immune Response to Viral Infection With H1N1

Frontiers in Medicine, 2020
Smokers with apparently “healthy” lungs suffer from more severe and frequent viral respiratory infections, but the mechanisms underlying this observation are still unclear.
Olga Danov, Martin Wolff, Sabine Bartel, Sabine Bartel, Sebastian Böhlen, Helena Obernolte, Sabine Wronski, Danny Jonigk, Barbara Hammer, Draginja Kovacevic, Sebastian Reuter, Sebastian Reuter, Susanne Krauss-Etschmann, Susanne Krauss-Etschmann, Katherina Sewald   +14 more
doaj   +1 more source