Results 41 to 50 of about 782,946 (316)

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Nasal Chondromesenchymal Hamartoma, a Rare Tumor in Young Children: A Case Report

Otorhinolaryngology and Facial Plastic Surgery, 2023
Background: Nasal chondromesenchymal hamartoma (NCMH) is a very rare benign tumor of sinonasal tract with mixed components of predominantly mesenchymal and cartilaginous tissues which is mostly seen in infants and young children. Case presentation: We
Nasim Raad, Jahangir Ghorbani, Mahsa Rekabi, Maryam Yousefi Koosha, Mahboobeh Karimi-Galougahi   +4 more
doaj   +1 more source

Models of chronic obstructive pulmonary disease

, 2004
Chronic obstructive pulmonary disease (COPD) is a major global health problem and is predicted to become the third most common cause of death by 2020. Apart from the important preventive steps of smoking cessation, there are no other specific treatments ...
David A Groneberg, Chung K Fan, Chung, K. Fan, Groneberg, Jan David Alexander, Groneberg David A, K Fan Chung   +5 more
core   +1 more source

Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 [PDF]

, 2020
Background: Previous attempts to characterise the burden of chronic respiratory diseases have focused only on specific disease conditions, such as chronic obstructive pulmonary disease (COPD) or asthma.
Soriano, Joan B., GBD Chronic Respiratory Disease Collaborators, Violante FS   +2 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Infections in Chronic Lung Diseases

Infectious Disease Clinics of North America, 2007
Chronic lung diseases are prevalent worldwide and cause significant mortality and suffering. This article discusses infections that occur in three chronic lung diseases: chronic obstructive pulmonary disease, bronchiectasis, and cystic fibrosis. Rather than discussing the role of infections as etiology of these diseases, this article focuses on ...
Parameswaran, G. Iyer, Murphy, Timothy F.   +1 more
openaire   +2 more sources

Interleukin-6 and airflow limitation in chemical warfare patients with chronic obstructive pulmonary disease [PDF]

Objectives: Chronic obstructive pulmonary disease (COPD) is one of the main late complications of sulfur mustard poisoning. The aim of this study was to evaluate serum levels of interleukin (IL)-6 in war veterans with pulmonary complications of sulfur ...
خواجه دلوئی, محمد, Shahrzad Lari, توحیدی, محمد, آیت اللهی, حسین, محمدزاده لاری, شهرزاد, قبادی مراللو, حسن, عطاران, داود, بصیری, رضا, قانعی, مصطفی   +8 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Correlating changes in lung function with patient outcomes in chronic obstructive pulmonary disease: a pooled analysis.

, 2011
Background Relationships between improvements in lung function and other clinical outcomes in chronic obstructive pulmonary disease (COPD) are not documented extensively.
Pinault, Gregory, Nedelman Jerry, Jones, Paul W, James F Donohue, Jones, PW, Donohue, JF, Steve Pascoe, Pinault Gregory, Pascoe Steve, Donohue James F, Lassen Cheryl, Pinault, G, Pascoe, S, Nedelman, J, Pascoe, Steve, Jerry Nedelman, Paul W Jones, Lassen, Cheryl, Jones Paul W, Cheryl Lassen, Gregory Pinault, Nedelman, Jerry, Donohue, James F, Lassen, C   +23 more
core   +1 more source

Management and prevention of chronic obstructive pulmonary disease exacerbations: a state of the art review [PDF]

, 2009
Exacerbations of chronic obstructive pulmonary disease (COPD) are important events in the natural history of this prevalent and devastating condition. This review provides a concise, state of the art summary on prevention and management of exacerbations.
Hurst, JR, Hurst John R, Wedzicha Jadwiga A, Wedzicha, JA, John R Hurst, Jadwiga A Wedzicha   +5 more
core   +1 more source