Results 31 to 40 of about 1,228,703 (311)

Clinical significance of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): potential target for prevention of airway fibrosis and lung cancer

Clinical and Translational Medicine, 2014
Unfortunately, the research effort directed into chronic obstructive pulmonary disease (COPD) has been disproportionately weak compared to its social importance, and indeed it is the least researched of all common chronic conditions.
Sukhwinder Singh Sohal, Malik Quasir Mahmood, Eugene Haydn Walters   +2 more
doaj   +1 more source

Combined exome and whole-genome sequencing identifies mutations in ARMC4 as a cause of primary ciliary dyskinesia with defects in the outer dynein arm [PDF]

, 2013
Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous ciliopathy disorder affecting cilia and sperm motility. A range of ultrastructural defects of the axoneme underlie the disease, which is characterised by chronic respiratory symptoms ...
Alexandros Onoufriadis, Amelia Shoemark, Anthony T Moore, Antony, Bush, Chela T James, Chiara Bacchelli, Claire Hogg, Eddie M K Chung, Elisabeth M Rosser, Fliegauf, Gerard Pals, Gherman, Hannah M Mitchison, Hirst, Hjeij, Hozumi, Jeannette E Danke-Roelse, John J Sloper, Kennedy, Knowles, Loges, Lonergan, Miriam Schmidts, Mitali Patel, Mustafa M Munye, O'Toole, Olbrich, Ong, Onoufriadis, Papon, Peter J Scambler, Philip L Beales, Plagnol, Richard D Emes, Roy, Sarah Hull, Schultz, Shoemark, Speder, Stephen L Hart, Tarkar, Tewari, Xu, Yang, Zhang   +45 more
core   +3 more sources

Autophagy in chronic lung disease

, 2020
The development of chronic lung disease occurs as a consequence of multiple cellular events that involve an initial insult which often leads to the development of chronic inflammation, and the dysregulation of cellular proliferation and cell death mechanisms.
Alexandra C, Racanelli, Augustine M K, Choi, Mary E, Choi   +2 more
openaire   +3 more sources

Chronic lung diseases: entangled in extracellular matrix

European Respiratory Review, 2022
The extracellular matrix (ECM) is the scaffold that provides structure and support to all organs, including the lung; however, it is also much more than this. The ECM provides biochemical and biomechanical cues to cells that reside or transit through this micro-environment, instructing their responses.
Janette K. Burgess, Martin C. Harmsen
openaire   +3 more sources

NOVEL INSIGHTS INTO CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD): AN OVERVIEW [PDF]

European Medical Journal Respiratory, 2014
Chronic obstructive pulmonary disease (COPD) is mainly caused by smoking and presents with shortness of breath that is progressive and irreversible. It is a worldwide health problem and the fourth most common cause of chronic disability and mortality ...
Sukhwinder Singh Sohal, Mathew Suji Eapen, Shakti Dhar Shukla, Jo-Maree Courtney,, Malik Quasir Mahmood, Eugene Haydn Walters   +5 more
doaj  

Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin

Nature Communications, 2020
Extensive scars develop in deep wounds as opposed to superficial wounds but it is unclear why. Here, the authors use live imaging of physiologic wounds and scars formed ex vivo to show that fascia fibroblasts upregulate N-cadherin allowing coordinated ...
Dongsheng Jiang, Simon Christ, Donovan Correa-Gallegos, Pushkar Ramesh, Shruthi Kalgudde Gopal, Juliane Wannemacher, Christoph H. Mayr, Valerio Lupperger, Qing Yu, Haifeng Ye, Martin Mück-Häusl, Vijayanand Rajendran, Li Wan, Juan Liu, Ursula Mirastschijski, Thomas Volz, Carsten Marr, Herbert B. Schiller, Yuval Rinkevich   +18 more
doaj   +1 more source

Pulmonary Thromboembolism Followed by Deep Vein Thrombosis In A Young Man With G6PD Deficiency After ChAd0x1 nCoV-19 Vaccine Administration

Vaccine Research, 2021
Recently the term vaccine-induced immune thrombotic thrombocytopenia (VITT) used for individual which have thrombotic phenomena followed by ChAdOx1 nCoV-19 vaccine (AstraZeneca) administration against SARS coronavirus.
Arda Kiani, Atefeh Abedini, Zahra Sadat Rouhani , Mohammadhossein Banitorfi, Amirhossein Saeidi, Hamidreza Zaheri   +5 more
doaj   +1 more source

Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD. [PDF]

, 2017
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and a leading cause of mortality and morbidity worldwide. The aim of this study was to investigate the sex dependency of circulating metabolic profiles in COPD.Serum from healthy ...
Erle, David J, Heyder, Tina, Kamleh, Muhammad Anas, Kolmert, Johan, Levänen, Bettina, Naz, Shama, Reinke, Stacey N, Sköld, C Magnus, Snowden, Stuart, Wheelock, Craig E, Wheelock, Åsa M, Yang, Mingxing   +11 more
core   +1 more source

Risk factors for Haemophilus influenzae and pneumococcal respiratory tract colonization in CVID [PDF]

, 2018
To the Editor: Disease-specific studies focused on infection risk in common variable immune deficiencies (CVIDs) are needed to define strategies for controlling respiratory infections predominantly due to bacteria such as Streptococcus pneumoniae and ...
Camilli, Romina, Cardines, Rita, Cerquetti, Marina, Ciervo, Alessandra, Giufrè, Maria, Mancini, Fabiola, Milito, Cinzia, Pantosti, Annalisa, Pimentel de Araujo, Fernanda, Pulvirenti, Federica, Quinti, Isabella   +10 more
core   +1 more source

Relationship between Angiogenic Squamous Dysplasia and Bronchogenic Carcinoma in Patients Undergoing White Light Bronchoscopy

Canadian Respiratory Journal, 2012
OBJECTIVE: To better understand the characteristic morphology of angiogenic squamous dysplasia (ASD) and its association with different types of common bronchogenic carcinomas using routine white light bronchoscopy.
Shirin Karimi, Forouzan Mohammadi, Kian Khodadad, Makan Sadr, Leila Seyfollahi, Mohammad Reza Masjedi   +5 more
doaj   +1 more source